Remote Organ Damage Induced by Stroke: Molecular Mechanisms and Comprehensive Interventions DOI
Jie Wang, Sen Gao, Yue Cui

et al.

Antioxidants and Redox Signaling, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Significance: Damage after stroke is not only limited to the brain but also often occurs in remote organs, including heart, lung, liver, kidney, digestive tract, and spleen, which are frequently affected by complex pathophysiological changes. The organs human body closely connected, signals transmitted through various molecular substances could regulate changes of organs. Recent Advances: latest studies have shown that inflammatory response plays an important role organ damage stroke, can aggravate activating oxidative stress, sympathetic axis, hypothalamic disturbing immunological homeostasis. Remote cause brain, aggravating damage. Critical Issues: Therefore, in-depth exploration mechanisms adopting corresponding comprehensive intervention strategies become necessary reduce promote protection. Future Directions: strategy involves multifaceted treatment methods such as inflammation regulation, antioxidants, neural stem cell differentiation. It provides a promising alternative for recovery patients inspiration future research treatment. interconnected at level. Only levels we save protect greatest extent. Antioxid. Redox Signal. 00, 000-000.

Language: Английский

Lymphocyte Subset Imbalance in Cardiometabolic Diseases: Are T Cells the Missing Link? DOI Open Access

Francesca Picone,

Valentina Giudice, Concetta Iside

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 868 - 868

Published: Jan. 21, 2025

Cardiometabolic and cardiovascular diseases (CVDs) remain the leading cause of death worldwide, with well-established risk factors such as smoking, obesity, diabetes contributing to plaque formation chronic inflammation. However, emerging evidence suggests that immune system plays a more significant role in development progression CVD than previously thought. Specifically, finely tuned regulation lymphocyte subsets governs post-injury inflammation tissue damage resolution orchestrates functions activation endothelial cells, cardiomyocytes, fibroblasts CVD-associated lesions (e.g., atherosclerotic plaques). A deeper understanding system’s involvement will provide new insights into disease biology uncover novel therapeutic targets aimed at re-establishing homeostasis. In this review, we summarize current state knowledge on distribution CVD, including atherosclerosis, diabetes, hypertension, myocardial infarction, stroke.

Language: Английский

Citations

0
Nanoparticle-Based Biomarkers for Neurological Disorders DOI

Neelakanta Sarvashiva Kiran,

Chandrashekar Yashaswini,

Ankita Chatterjee

et al.

Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 183 - 202

Published: Jan. 1, 2025

Language: Английский

Citations

0
Remote Organ Damage Induced by Stroke: Molecular Mechanisms and Comprehensive Interventions DOI
Jie Wang, Sen Gao, Yue Cui

et al.

Antioxidants and Redox Signaling, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Significance: Damage after stroke is not only limited to the brain but also often occurs in remote organs, including heart, lung, liver, kidney, digestive tract, and spleen, which are frequently affected by complex pathophysiological changes. The organs human body closely connected, signals transmitted through various molecular substances could regulate changes of organs. Recent Advances: latest studies have shown that inflammatory response plays an important role organ damage stroke, can aggravate activating oxidative stress, sympathetic axis, hypothalamic disturbing immunological homeostasis. Remote cause brain, aggravating damage. Critical Issues: Therefore, in-depth exploration mechanisms adopting corresponding comprehensive intervention strategies become necessary reduce promote protection. Future Directions: strategy involves multifaceted treatment methods such as inflammation regulation, antioxidants, neural stem cell differentiation. It provides a promising alternative for recovery patients inspiration future research treatment. interconnected at level. Only levels we save protect greatest extent. Antioxid. Redox Signal. 00, 000-000.

Language: Английский

Citations

0