State-of-the-art photodynamic therapy for malignant gliomas: innovations in photosensitizers and combined therapeutic approaches
Exploration of Targeted Anti-tumor Therapy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Glioblastoma
(GBM),
the
most
aggressive
and
lethal
primary
brain
tumor,
poses
a
significant
therapeutic
challenge
due
to
its
highly
invasive
nature
resistance
conventional
therapies,
including
surgery,
chemotherapy,
radiotherapy.
Despite
advances
in
standard
treatments,
patient
survival
remains
limited,
requiring
exploration
of
innovative
strategies.
Photodynamic
therapy
(PDT)
has
emerged
as
promising
approach,
leveraging
light-sensitive
photosensitizers
(PSs),
molecular
oxygen,
specific
light
wavelengths
generate
reactive
oxygen
species
(ROS)
that
selectively
induce
tumor
cell
death.
Originally
developed
for
skin
cancer,
PDT
evolved
target
more
complex
malignancies,
GBM.
The
refinement
second-
third-generation
PS,
coupled
with
advancements
nanotechnology,
significantly
improved
PDT's
selectivity,
bioavailability,
efficacy.
Moreover,
combination
targeted
therapy,
immunotherapy,
among
other
modalities,
shown
potential
enhancing
outcomes.
This
review
provides
comprehensive
analysis
preclinical
clinical
applications
GBM,
detailing
mechanisms
action,
evolution
novel
combinatory
strategies
optimize
treatment
However,
several
challenges
remain,
overcoming
GBM-associated
hypoxia,
PS
delivery
across
blood-brain
barrier,
mitigating
mechanisms.
integration
genetic
insight,
alongside
cutting-edge
nanotechnology-based
systems,
may
revolutionize
GBM
treatment,
offering
new
prospects
quality
life.
Language: Английский
Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence
K Sandhanam,
No information about this author
Tamilanban Thamaraikani,
No information about this author
K. Manasa
No information about this author
et al.
Neuroscience,
Journal Year:
2024,
Volume and Issue:
553, P. 1 - 18
Published: June 27, 2024
Language: Английский
Functionalized Nanomaterials in Cancer Treatment: A Review
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2633 - 2633
Published: March 14, 2025
Cancer
is
one
of
the
main
causes
death
worldwide.
Chemotherapy,
radiotherapy
and
surgery
are
currently
treatments
choice
for
cancer.
However,
conventional
therapies
have
their
limitations,
such
as
non-specificity,
tumor
recurrence
toxicity
to
target
cells.
Recently,
nanomaterials
been
considered
therapeutic
agents
against
This
mainly
due
unique
optical
properties,
biocompatibility,
large
surface
area
nanoscale
size.
These
properties
crucial
they
can
affect
biocompatibility
uptake
by
cell,
reducing
efficacy.
because
nanoparticles
be
functionalized
with
biomolecules,
become
more
biocompatible,
which
improves
uptake,
specifically
targeted
cancer
cells,
anticancer
activity.
In
this
review,
we
summarize
some
recent
studies
in
aim
increasing
efficacy
treatment.
Language: Английский
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 30, 2025
A
notable
increase
in
cancer-related
fatalities
and
morbidity
worldwide
is
attributed
to
drug
resistance.
The
factors
contributing
resistance
include
efflux
via
ABC
transporters,
apoptosis
evasion,
epigenetic
alterations,
DNA
repair
mechanisms,
the
tumor
microenvironment,
among
others.
Systemic
toxicities
associated
with
conventional
cancer
diagnostics
therapies
have
led
development
of
alternative
approaches,
such
as
nanotechnology,
enhance
diagnostic
precision
improve
therapeutic
outcomes.
Nanomaterial,
including
carbon
nanotubes,
dendrimers,
polymeric
micelles,
liposomes,
shown
significant
benefits
diagnosis
treatment
due
their
unique
physicochemical
properties,
biocompatibility,
stability,
enhanced
permeability,
retention
characteristics,
targeted
delivery.
Building
on
these
advantages,
this
review
conducted
through
comprehensive
analysis
recent
literature
explore
principal
mechanisms
resistance,
potential
nanomaterials
revolutionize
selective
delivery
treatment.
Additionally,
strategies
employed
by
overcome
tumors,
pump
inhibition,
multidrug
loading,
gene
silencing
are
discussed
detail.
Furthermore,
we
examine
challenges
that
limit
application
impede
transition
clinical
use.
Language: Английский
Insights into cellular and molecular mechanisms of graphene oxide nanoparticles in photothermal therapy for hepatocellular carcinoma
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 3, 2025
Language: Английский
Exploring barley bran as a precursor for carbon quantum dots with enhanced fluorescence characteristics
Diamond and Related Materials,
Journal Year:
2025,
Volume and Issue:
156, P. 112421 - 112421
Published: May 6, 2025
Language: Английский
The Role of Inorganic Nanomaterials in Overcoming Challenges in Colorectal Cancer Diagnosis and Therapy
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(4), P. 409 - 409
Published: March 25, 2025
Colorectal
cancer
poses
a
significant
threat
to
human
health
due
its
high
aggressiveness
and
poor
prognosis.
Key
factors
impacting
patient
outcomes
include
post-surgical
recurrence,
chemotherapeutic
drug
resistance,
insensitivity
immunotherapy.
Consequently,
early
diagnosis
the
development
of
effective
targeted
therapies
are
essential
for
improving
prevention
treatment
strategies.
Inorganic
nanomaterials
have
gained
prominence
in
colorectal
owing
their
unique
size,
advantageous
properties,
modifiability.
Various
types
inorganic
nanomaterials—such
as
metal-based,
metal
oxide,
quantum
dots,
magnetic
nanoparticles,
carbon-based,
rare-earth
nanomaterials—have
demonstrated
potential
enhancing
multimodal
imaging,
delivery,
synergistic
therapies.
These
advancements
underscore
critical
role
therapeutic
outcomes.
This
review
highlights
properties
nanomaterials,
summarizes
recent
applications
progress
treatment,
discusses
challenges
translating
these
materials
into
clinical
use.
It
aims
provide
valuable
insights
future
research
application
management.
Language: Английский
Breaking the Resistance: Photodynamic Therapy in Cancer Stem Cell-Driven Tumorigenesis
Sheeja S. Rajan,
No information about this author
J. P. Jose Merlin,
No information about this author
Heidi Abrahamse
No information about this author
et al.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(5), P. 559 - 559
Published: April 24, 2025
Cancer
stem
cells
(CSCs)
are
essential
for
the
growth
of
malignancies
because
they
encourage
resistance
to
cancer
therapy
and
make
metastasis
relapse
easier.
To
effectively
tackle
obstacles
presented
by
CSCs,
novel
therapeutic
approaches
required.
Photodynamic
(PDT)
is
a
promising
treatment
option
cells,
which
uses
light-sensitive
medications
that
activated
light
wavelengths.
This
review
investigates
use
PDT
overcome
driven
CSCs
have
innate
mechanisms.
works
causing
tumor
accumulate
photosensitizers
(PSs)
selectively.
The
reactive
oxygen
species
(ROS),
kill
released
these
PSs
when
stimulated
light.
According
recent
developments
in
PDT,
its
efficacy
may
go
beyond
traditional
providing
viable
remedy
shown
CSCs.
Researchers
want
improve
targeted
elimination
selective
targeting
combining
with
new
customized
delivery
systems.
Studies
emphasize
how
affects
as
well
bulk
cells.
studies,
not
only
limits
CSC
but
also
modifies
their
microenvironment,
lowers
possibility
recovery.
Additionally,
studies
being
conducted
on
utilization
immunotherapeutic
techniques
inherent
In
conclusion,
strategy
treating
carcinogenesis
By
applying
most
advancements
technologies
recognizing
it
interacts
this
has
potential
surpass
mechanisms
future
patients.
Clinical
preclinical
highlight
CSC-targeted
current
limitations.
Future
efforts
should
focus
clinical
validation,
optimizing
PS
use,
developing
effective
combination
strategies
target
Language: Английский
Innovative Nanoscale Drug Delivery Strategies for Breast Carcinoma: A Comprehensive Exploration
Sharma Jaishree,
No information about this author
Kousalya Selvaraj,
No information about this author
Shobha Prakash
No information about this author
et al.
Current Drug Metabolism,
Journal Year:
2024,
Volume and Issue:
25(6), P. 391 - 402
Published: Aug. 7, 2024
Breast
cancer
(BC)
is
one
of
the
major
causes
poor
health
in
women
and
most
devastating
disease
after
lung
cancer.
The
term
"cancer"
refers
to
a
collection
problems
resulting
from
abnormal
cell
proliferation,
particularly
cells
that
can
spread
other
parts
body.
Surgery,
followed
by
chemotherapy
or
radiotherapy,
now
accepted
for
BC-related
cancers.
However,
radiotherapy
are
rarely
effective
treatment
BC
due
adverse
effects
these
treatments
on
healthy
tissues
organs.
Consequently,
use
NPs
targeted
Drug
Delivery
Systems
(DDSs)
has
emerged
as
promising
strategy
treatment.
This
review
provides
summary
recent
clinical
investigations
nanoparticle-mediated
DDS
offer
novel
therapeutic
commonly
used
breast
Language: Английский
The new metal-free, zinc, magnesium, indium ball-type phthalocyanines and their hybrids with graphene oxide: Synthesis, investigation of photophysical, photochemical properties and theoretical studies
Ketrin Zeki,
No information about this author
Süeda Asrak,
No information about this author
Fatma Nur Yabaş
No information about this author
et al.
Journal of Photochemistry and Photobiology A Chemistry,
Journal Year:
2024,
Volume and Issue:
461, P. 116138 - 116138
Published: Nov. 7, 2024
Language: Английский