Dietary flavonoid intake is negatively associated with accelerating aging: an American population-based cross-sectional study DOI Creative Commons

Jintao Zhong,

Jiamin Fang,

Yixuan Wang

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 20, 2024

Flavonoids are believed to have potential anti-aging effects due their anti-inflammatory and antioxidant properties. However, the effectiveness of dietary flavonoids subclasses in delaying aging has yet be confirmed. Our study intends examine relationship between them. Data from three survey cycles (2007–2008, 2009–2010, 2017–2018) National Health Nutrition Examination Survey (NHANES) was used investigate PhenoAgeAccel flavonoid intake. Weighted linear regression conducted evaluate intake PhenoAgeAccel, dose-response investigated by limited cubic spline (RCS) analysis. Mixed were explored using weighted quantile sum (WQS) regression. Further, subgroup analyses also conducted. A total 5391 participants included, after multivariable adjustments, a negative association found with flavonoid, flavan-3-ols, flavanone, flavones flavonols β (95% CI) -0.87 ( -1.61, -0.13), -0.83 (-1.95, -0.08), -1.18 (-1.98, -0.39), -1.64 (-2.52, -0.77) − 1.18 -0.39) for higher quintile compared lowest quintile. The RCS analysis show non-linear flavan-3-ols (P nonlinear = 0.024), flavanones 0.005), < 0.001), 0.001) PhenoAgeAccel. WQS indicated that had primary effect on mixture exposures (52.72%). Finally, without chronic kidney disease more likely benefit flavanone flavone mitigating aging, while benefits significant lower body mass index. suggested is negatively associated accelerating adults American, most influential ones flavones, flavanones, flavonols.

Language: Английский

Dietary flavonoid intake is negatively associated with accelerating aging: an American population-based cross-sectional study DOI Creative Commons

Jintao Zhong,

Jiamin Fang,

Yixuan Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract Background Flavonoids are believed to have potential anti-aging effects due their anti-inflammatory and antioxidant properties. However, the effectiveness of dietary flavonoids subclasses in delaying aging has yet be confirmed. Our study intends examine relationship between them. Methods Data from three survey cycles (2007–2008, 2009–2010, 2017–2018) National Health Nutrition Examination Survey (NHANES) was used investigate PhenoAgeAccel flavonoid intake. Weighted linear regression conducted evaluate intake PhenoAgeAccel, dose-response investigated by limited cubic spline (RCS) analysis. Mixed were explored using weighted quantile sum (WQS) regression. Further, subgroup analyses also conducted. Results A total 5391 participants included, after multivariable adjustments, a negative association found with flavonoid, flavan-3-ols, flavanone, flavones flavonols β (95% CI) -0.87 ( -1.61, -0.13), -0.83 (-1.95, -0.08), -1.18 (-1.98, -0.39), -1.64 (-2.52, -0.77) − 1.18 -0.39) for higher quintile compared lowest quintile. The RCS analysis show non-linear flavan-3-ols (P nonlinear = 0.024), flavanones 0.005), < 0.001), 0.001) PhenoAgeAccel. WQS indicated that had primary effect on mixture exposures (52.72%). Finally, without chronic kidney disease more likely benefit flavanone flavone mitigating aging, while benefits significant lower body mass index. Conclusion suggested is negatively associated accelerating adults American, most influential ones flavones, flavanones, flavonols.

Language: Английский

Citations

0
Dietary flavonoid intake is negatively associated with accelerating aging: an American population-based cross-sectional study DOI Creative Commons

Jintao Zhong,

Jiamin Fang,

Yixuan Wang

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 20, 2024

Flavonoids are believed to have potential anti-aging effects due their anti-inflammatory and antioxidant properties. However, the effectiveness of dietary flavonoids subclasses in delaying aging has yet be confirmed. Our study intends examine relationship between them. Data from three survey cycles (2007–2008, 2009–2010, 2017–2018) National Health Nutrition Examination Survey (NHANES) was used investigate PhenoAgeAccel flavonoid intake. Weighted linear regression conducted evaluate intake PhenoAgeAccel, dose-response investigated by limited cubic spline (RCS) analysis. Mixed were explored using weighted quantile sum (WQS) regression. Further, subgroup analyses also conducted. A total 5391 participants included, after multivariable adjustments, a negative association found with flavonoid, flavan-3-ols, flavanone, flavones flavonols β (95% CI) -0.87 ( -1.61, -0.13), -0.83 (-1.95, -0.08), -1.18 (-1.98, -0.39), -1.64 (-2.52, -0.77) − 1.18 -0.39) for higher quintile compared lowest quintile. The RCS analysis show non-linear flavan-3-ols (P nonlinear = 0.024), flavanones 0.005), < 0.001), 0.001) PhenoAgeAccel. WQS indicated that had primary effect on mixture exposures (52.72%). Finally, without chronic kidney disease more likely benefit flavanone flavone mitigating aging, while benefits significant lower body mass index. suggested is negatively associated accelerating adults American, most influential ones flavones, flavanones, flavonols.

Language: Английский

Citations

0