Preparation, antioxidant, antibacterial, and in vivo evaluation of pomegranate flower extract nanofibers based on thiolated chitosan and gelatin for treating aphthous stomatitis DOI
Maryam Ebrahimnia,

Shahram Rabbani,

Arash Mahboubi

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 351, P. 122971 - 122971

Published: Nov. 12, 2024

Language: Английский

QbD Manoeuvred Niclosamide Laden Polylactic-co-Glycolic Acid Nanoparticles-Impregnated Gelatin Nanofibers for the Management of Oral Carcinoma DOI
Saurabh Shah,

Paras Famta,

Rahul Kumar

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 5, 2025

Language: Английский

Citations

8
Harnessing Electrospun Nanofibers for Comprehensive Oral Disease Management: Current Trends and Future Perspectives DOI

R.S. Gupta,

Giriraj Pandey,

Ajay Kumar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106681 - 106681

Published: Feb. 7, 2025

Language: Английский

Citations

5
Exploring advancements in polysaccharide-based approaches: The cornerstone of next-generation cartilage regeneration therapeutics DOI
Noella Abraham,

Giriraj Pandey,

Tejaswini Kolipaka

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141352 - 141352

Published: Feb. 1, 2025

Language: Английский

Citations

3
HER-2 Receptor and αvβ3 Integrin Dual-Ligand Surface-Functionalized Liposome for Metastatic Breast Cancer Therapy DOI Creative Commons
Dilip Kumar Arya, Hemali Deshpande, Ashish Kumar

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1128 - 1128

Published: Aug. 27, 2024

Human epidermal growth factor receptor-2 (HER2)-positive breast cancer metastasis remains the primary cause of mortality among women globally. Targeted therapies have revolutionized treatment efficacy, with Trastuzumab (Trast), a monoclonal antibody, targeting HER2-positive advanced cancer. The tumor-homing peptide iRGD enhances intratumoral accumulation and penetration therapeutic agents. Liposomes serve as versatile nanocarriers for both hydrophilic hydrophobic drugs. Gefitinib (GFB) is potential anticancer drug against cancer, while Lycorine hydrochloride (LCH) natural compound anti-inflammatory properties. This study developed TPGS-COOH-coated liposomes co-loaded GFB LCH, prepared by solvent injection method, surface-functionalized Trast iRGD. dual surface-decorated (DSDLs) were characterized their particle size (PS), polydispersity index (PDI), zeta (ZP), surface chemistry, morphology, crystallinity during in-vitro release, encapsulation, cell line studies on SK-BR-3 MDA-MB-231 cells. half-maximum inhibitory concentration (IC-50) values single decorated (SDLs), iRGD-LP, Trast-LP, well DSDLs (iRGD-Trast-LP) cells, 6.10 ± 0.42, 4.98 0.36, 4.34 0.32 μg/mL, respectively. Moreover, IC-50 SDLs cells 15.12 0.68, 13.09 0.59, 11.08 0.48 Cellular uptake using confocal laser scanning microscopy (CLSM) showed that functionalization significantly enhanced cellular in lines. wound-healing assay demonstrated significant reduction SDL DSDL-treated migration compared to control. Additionally, blood compatibility minimal hemolysis (less than 5% RBC lysis), indicating good biocompatibility biosafety. Overall, these findings suggest TPGS-COOH-coated, LCH co-loaded, dual-ligand (iRGD Trast) functionalized, multifunctional could be promising strategy treating metastatic

Language: Английский

Citations

7
Therapeutic effect of pH responsive Magainin II modified azithromycin plus curcumin micelles in different depth models of MRSA infection DOI Creative Commons
Lu Zhang,

Rui-bo Guo,

Liu Yang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen responsible for serious infections in humans. The overuse of antibiotics has led to the evolution resistance genes bacteria. This study aimed develop pH-responsive micelle, loaded with therapy drugs and modified antimicrobial peptides, treat drug-resistant bacterial at varying depths. micelles containing azithromycin curcumin, Magainin II, were prepared using thin-film dispersion method. physicochemical properties characterized, their targeting therapeutic effects on investigated both vivo vitro across various demonstrated excellent infection sites released response degradation disease site. combination curcumin effectively mitigated through multiple mechanisms, enhancing antibacterial effect while reducing required dosage associated toxicity. In models depths—skin, muscle, lungs—the exhibited strong antibacterial, anti-biofilm, anti-inflammatory low These findings provide promising strategy addressing infections.

Language: Английский

Citations

1
Poly(vinyl alcohol)/Polycaprolactone Nanofiber Enriched with Lichenysin against Multidrug-Resistance Bacterial Infection in Wound Healing: In Vitro Studies and In Vivo Evaluation in Wistar Rats DOI
Swati Yadav, Dilip Kumar Arya, Shubham Kanaujiya

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Multidrug resistance (MDR) infectious wounds are a major concern due to drug resistance, leading increased patient morbidity. Lichenysin (LCN), lipopeptide and biosurfactant obtained from certain strains of Bacillus licheniformis, has demonstrated an excellent antimicrobial property. The present study focuses on the fabrication comprehensive evaluation LCN-incorporated poly(vinyl alcohol) (PVA)/polycaprolactone (PCL)-based nanofiber scaffolds using electrospinning technique as potential wound healing biomaterial for treatment MDR in diabetic rats. LCN-loaded PVA–PCL were characterized their physicochemical, antimicrobial, vitro cell line L-929, hemocompatibility, flow cytometry, vivo healing, enzyme-linked immuno sorbent assay (ELISA). Morphological analysis via scanning electron microscopy (SEM) images confirmed smooth porous nanofibers with diameters range 200–300 nm. Fourier transform infrared X-ray diffraction (XRD) results structural integrity, chemical compatibility, amorphous nature developed scaffolds. loaded LCN water retention, moderate biodegradability, sustained release up 72 h. Mechanical characterization robust tensile strength conducive applications. Antimicrobial activity against Pseudomonas aeruginosa (P. aeruginosa) Staphylococcus aureus (S. aureus) showed substantial antibacterial antibiofilm activity. In studies enhanced adhesion, proliferation, migration, viability, signifying cytocompatibility these exceptional These findings indicate that LCN-enriched hold significant therapeutic strategy rats through multifaceted approach.

Language: Английский

Citations

0
Harnessing marine antimicrobial peptides for novel therapeutics: A deep dive into ocean-derived bioactives DOI
Kunal Agam Kanaujia,

Suraj Wagh,

Giriraj Pandey

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 142158 - 142158

Published: March 17, 2025

Language: Английский

Citations

0
Navigating the Complexities of Diabetic Foot Ulcers: From Pathophysiology to Advanced Treatment Strategies DOI

Giriraj Pandey,

Tejaswini Kolipaka,

Dadi A. Srinivasarao

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106852 - 106852

Published: March 1, 2025

Language: Английский

Citations

0
Advancements in Skin Tissue Regeneration: Unveiling Emerging Treatment Strategies, Regulatory Perspectives, and Future Directions for Enhanced Healing DOI

Pawan Jaiswal,

Giriraj Pandey,

Shivam Kumar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106872 - 106872

Published: April 1, 2025

Language: Английский

Citations

0
Establishment and Evaluation of Paclitaxel and Simvastatin-Laden Nanofibers for Post-surgical Tumor Recurrence in Breast Cancer DOI

Paras Famta,

Saurabh Shah,

Ganesh Vambhurkar

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(3)

Published: May 21, 2025

Language: Английский

Citations

0