European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177308 - 177308
Published: Jan. 1, 2025
Language: Английский
International Communications in Heat and Mass Transfer, Journal Year: 2025, Volume and Issue: 164, P. 108895 - 108895
Published: March 29, 2025
Language: Английский
Citations
1
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0315435 - e0315435
Published: Jan. 2, 2025
The use of granulocyte colony-stimulating factor (GCSF) to control febrile neutropenia (FN) caused by anti-cancer chemotherapy is well documented but it still needs evaluated with respect the specific type cancer and chemotherapeutic agents. present study evaluates efficacy adjunctive GCSF for treating FN after taking anticancer therapy measuring clinical, hematological microbiological outcomes. It a single center conducted at Hayatabad Medical Complex (HMC), Peshawar, Pakistan. Adult patients both genders, suffering from different types sarcomas were included in study. was between January 2023 2024. Baseline data including demographic data, medication history evaluation all recorded time enrolment. Primary outcomes extent absolute neutrophil count (ANC) recovery, duration severity (grade IV), period fever resolution. After (with without GCSF) clinical outcomes, compared evaluated. All statistically analyzed SPSS (IBMS, version 20). A total number 120 investigated out which 109 included. Out patients, 64 (58.72%) received therapy, 45 (41.28%) did not receive GCSF. Comparison showed that receiving had significant improvement ANC recovery time, better free infections. This concluded benefits undergoing treatment carcinoma.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Colon cancer is one kind of malignant digestive tract tumor with high morbidity and mortality worldwide, treatments for which still face great challenges. Recently emerged intervention strategies such as phototherapy gas therapy have displayed promising effects in the treatment colon cancer, but their application are hindered due to insufficient targeting deeper tissue penetrating capacity. Herein, present study, we developed theranostic nanoplatform Cet-CDs-SNO (CCS) realize multimodal imaging-guided synergistic therapy. Among CCS, Cetuximab (Cet), first-line clinical drugs colorectal endowed CCS tumor-targeting capacity enhanced drug accumulation cells; CDs doped by Ni2+ Mn2+ served NIR-II photothermal (PTT), chemodynamic (CDT), photothermal/magnetic resonance/fluorescence imaging (PTI/MRI/FLI) agents; SNO, a nitric oxide (NO) donor, exerted therapeutic (GT) under thermal stimulation derived from PTT. In vitro vivo experiments proved that had excellent cancer-targeting ability. Proliferation cells growth were significantly inhibited administration without detectable cytotoxicity. This study presented strategy developing multifunctional be applied precise
Language: Английский
Citations
0
Microscopy Research and Technique, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Microscopic imaging aids disease diagnosis by describing quantitative cell morphology and tissue size. However, the high spatial resolution of these images poses significant challenges for manual evaluation. This project proposes using computer-aided analysis methods to address challenges, enabling rapid precise clinical diagnosis, course analysis, prognostic prediction. research introduces advanced deep learning frameworks such as squeeze-and-excitation dilated dense convolution blocks tackle complexities quantifying small intricate breast cancer tissues meeting real-time requirements pathological image analysis. Our proposed framework integrates a convolutional network (DenseNet) with an attention mechanism, enhancing capability accurate assessments. These multi-classification models facilitate prediction segmentation lesions in microscopic leveraging lightweight multi-scale feature extraction, dynamic region attention, sub-region classification, regional regularization loss functions. will employ transfer paradigms data enhancement enhance models' further prevent overfitting. We propose fine-tuning employing pre-trained architectures VGGNet-19, ResNet152V2, EfficientNetV2-B1, DenseNet-121, modifying final pooling layer each model's last block SPP associated BN layer. The study uses labeled unlabeled robust features classification abilities. method reduces costs time traditional methods, alleviating burden labeling computational pathology. goal is provide sophisticated, efficient solution, improving outcomes advancing field. model, trained, validated, tested on microscope dataset, achieved recognition accuracy 99.6% benign malignant secondary 99.4% eight subtypes classification. approach demonstrates substantial improvement compared existing which generally report lower accuracies subtype ranging between 85% 94%. level underscores potential our reliable diagnostic support, precision decision-making.
Language: Английский
Citations
0
Analytical Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 115767 - 115767
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 403 - 444
Published: Jan. 1, 2025
Abstract: Nanotechnology has emerged as a revolutionary domain with diverse applications in medicine, and one of the noteworthy developments is exploration bacterial magnetosomes acquired from magnetotactic bacteria (MTB) for therapeutic purposes. The demand natural nanomaterials biomedical field continuously increasing due to their biocompatibility eco-friendly nature. MTB produces uniform, well-ordered magnetic nanoparticles inside magnetosomes, drawing attention unique remarkable features. have gained popularity cancer treatment diagnosis, especially resonance imaging. Distinctive features highlighted include advancements extraction, characterization, functionalization techniques, alongside breakthroughs utilizing MTB-based contrast agents imaging, biocompatible drug carriers, tools minimally invasive therapies. nature, functionalizing surface response external make them potential candidate theragnostic purpose magnetosomes. In present review, emphasis been given foundation at genetic level, mass production etc. Further authors reviewed various methods treatment. Finally, recent magnetosome-based detection, Challenges such scalability, long-term safety, clinical translation are also discussed, presenting roadmap future research exploiting MTBs magnetosomes' properties. Keywords: bacteria, hyperthermia, gene therapy, nanomedicine
Language: Английский
Citations
0
Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Language: Английский
Citations
0
Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102517 - 102517
Published: Jan. 1, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Language: Английский
Citations
0
Bioengineering, Journal Year: 2025, Volume and Issue: 12(1), P. 65 - 65
Published: Jan. 14, 2025
This paper reviews the main research on Optical Coherence Tomography (OCT), focusing progress and advancements made by researchers over past three decades in its methods medical imaging applications. By analyzing existing studies developments, this review aims to provide a foundation for future field.
Language: Английский
Citations
0