Tumor-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via PI3K/Akt/mTOR pathway DOI Creative Commons
Liuqing He, Quan Chen, Xiaoying Wu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Background Tumour-associated macrophages (TAMs) are the most abundant immune cells in tumour environment and considered to be similar M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of cross-talk between tumor tumour-associated can development metastasis ovarian by mediates macrophage polarization. However, exact mechanisms underlying communication (OC) during progression remain unclear. Results Herein, we demonstrated that high expression miR-205 was associated with infiltration affected prognosis OC patients. Importantly, tumor-derived could transported from via exosomes promote cell invasion inducing M2-like polarisation. Animal experiments further confirmed exosomal-miR-205-induced accelerate vivo. Mechanistically, downregulates PTEN, activating PI3K/AKT/mTOR signaling pathway, is critical for Conclusions These results reveal exosomal plays a pivotal role polarization within microenvironment, highlighting its potential therapeutic target treatment. This study not only enhances our understanding interactions but also opens new avenues targeted therapies against cancer.

Language: Английский

Tumour-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via the PI3K/Akt/mTOR pathway DOI Creative Commons
Liuqing He, Quan Chen, Xiaoying Wu

et al.

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 15, 2025

Tumour-associated macrophages (TAMs) are the most abundant immune cells in tumour environment and considered similar to M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of cross-talk between tumour-associated can development metastasis ovarian by mediating macrophage polarization. However, exact mechanisms underlying communication (OC) during OC progression remain unclear. Here, we demonstrated that high expression miR-205 was associated with infiltration, affected prognosis patients. Importantly, tumour-derived could be transported from via exosomes promote cell invasion inducing M2-like Animal experiments further confirmed exosomal miR-205-induced accelerated vivo. Mechanistically, downregulated PTEN, activating PI3K/AKT/mTOR signalling pathway, is critical for These results reveal plays a pivotal role polarization within microenvironment, highlighting its potential therapeutic target treatment. This study not only enhances our understanding interactions but also opens new avenues targeted therapies against cancer.

Language: Английский

Citations

0
The role of macrophages in liver metastasis: mechanisms and therapeutic prospects DOI Creative Commons
Qin Yuan,

Linlin Jia,

Jiahua Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Metastasis is a hallmark of advanced cancer, and the liver common site for secondary metastasis many tumor cells, including colorectal, pancreatic, gastric, prostate cancers. Macrophages in microenvironment (TME) promote cell through various mechanisms, angiogenesis immunosuppression, play unique role development metastasis. are affected by variety factors. Under conditions hypoxia increased acidity TME, more factors now found to polarization macrophages M2 type, exosomes amino acids. M2-type secretion such as VEGF, IL-1β, TGF-β1. subjected multiple regulatory mechanisms. They also interact with cells within co-regulate certain conditions, creation an immunosuppressive microenvironment. This interaction promotes metastasis, drug resistance, immune escape. Based on advent single-cell sequencing technology, further insights into macrophage subpopulations may help exploring new therapeutic targets future. In this paper, we will focus how affect well other each other, investigate mechanisms involved their potential targets.

Language: Английский

Citations

0
Tumor microenvironment in oral squamous cell carcinoma DOI Creative Commons

Chenxi Li,

Xiaodan Dong, Bo Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Oral squamous cell carcinoma (OSCC) is a highly aggressive and malignant tumor of oral cavity with poor prognosis high mortality due to the limitations existing therapies. The significant role microenvironment (TME) in initiation, development, progression OSCC has been widely recognized. Various cells TME, including tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), T lymphocytes, neutrophils (TANs), myeloid-derived suppressor (MDSCs) dendritic (DCs), form complicated important cellular network modulate proliferation, invasion, migration, angiogenesis by secreting RNAs, proteins, cytokines, metabolites. Understanding interactions among TME provides foundation for advanced clinical diagnosis This review summarizes current literature that describes various components other factors OSCC, hoping provide new ideas novel treatment strategies targeting mediate interactive loops TME.

Language: Английский

Citations

1
Tumor-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via PI3K/Akt/mTOR pathway DOI Creative Commons
Liuqing He, Quan Chen, Xiaoying Wu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Background Tumour-associated macrophages (TAMs) are the most abundant immune cells in tumour environment and considered to be similar M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of cross-talk between tumor tumour-associated can development metastasis ovarian by mediates macrophage polarization. However, exact mechanisms underlying communication (OC) during progression remain unclear. Results Herein, we demonstrated that high expression miR-205 was associated with infiltration affected prognosis OC patients. Importantly, tumor-derived could transported from via exosomes promote cell invasion inducing M2-like polarisation. Animal experiments further confirmed exosomal-miR-205-induced accelerate vivo. Mechanistically, downregulates PTEN, activating PI3K/AKT/mTOR signaling pathway, is critical for Conclusions These results reveal exosomal plays a pivotal role polarization within microenvironment, highlighting its potential therapeutic target treatment. This study not only enhances our understanding interactions but also opens new avenues targeted therapies against cancer.

Language: Английский

Citations

0