CRISPR/Cas-mediated macromolecular DNA methylation editing: Precision targeting of DNA methyltransferases in cancer therapy

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142401 - 142401

Published: March 1, 2025

Language: Английский

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Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Atherosclerosis, the primary cause of coronary artery disease (CAD), remains a leading global mortality. It is characterized by accumulation cholesterol-rich plaques and inflammation, which narrow arteries increase risk rupture. To elucidate this complex biological process improve therapeutic strategies, CAD has been extensively explored from an epigenetic perspective over past two decades. Epigenetics field investigating heritable alterations in gene expression without DNA sequence changes, such as methylation, histone modifications, non-coding RNAs. Increasing evidence indicated that development significantly influenced changes. Meanwhile, impact epigenetics now transitioning pathophysiology to therapeutics. Focusing on key enzymes their target genes will help facilitate diagnosis treatment CAD. This review synthesizes novel insights into CAD, addressing pathological processes, molecular mechanisms, potential biomarkers. Furthermore, we discuss emerging strategies targeting pathways. By focusing pivotal associated genes, work aims advance diagnostics interventions.

Language: Английский

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Emerging Epigenetic Therapies for the Treatment of Cardiac Fibrosis

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1170 - 1170

Published: May 11, 2025

Fibrosis is a pathological process characterized by excessive extracellular matrix (ECM) deposition, leading to tissue stiffening and organ dysfunction. It major contributor chronic diseases affecting various organs, with limited therapeutic options available. Among the different forms of fibrosis, cardiac fibrosis particularly relevant due its impact on cardiovascular (CVDs), which remain cause morbidity mortality worldwide. This driven activated fibroblasts (CFs), promote ECM accumulation in response stressors. Epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, are key regulators fibroblast activation fibrotic gene expression. Enzymes such as methyltransferases (DNMTs), (HMTs), acetyltransferases (HATs), deacetylases (HDACs) have emerged potential targets, epigenetic inhibitors shown promise modulating these enzymes attenuate controlling function deposition. These small-molecule compounds offer advantages reversibility precise temporal control, making them attractive candidates for intervention. review aims provide comprehensive overview mechanisms influence examines latest advances preclinical therapies. By integrating recent data from functional studies, single-cell profiling, drug development, it highlights molecular emerging strategies, current limitations, offering critical framework guide future research clinical translation.

Language: Английский

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Advancing the potential of nanoparticles for cancer detection and precision therapeutics

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(7)

Published: June 4, 2025

Language: Английский

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