Regional and Gender-Based Distribution of KRAS Mutations in Metastatic Colorectal Cancer Patients in Turkey: An Observational Study DOI Creative Commons
Nurullah İlhan, Faysal Dane, Erdem Göker

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 694 - 694

Published: April 10, 2025

Background and Objectives: KRAS genes are among the most prominent oncogenes that trigger tumor formation in colorectal cancer (CRC) serve as predictive biomarkers for resistance to anti-EGFR therapies metastatic (mCRC) patients. However, prevalence mutation spectrum of gene family mCRC patients Turkey have not been sufficiently analyzed. This study investigates frequency distribution mutations across different regions examines gender-related variations. Materials Methods: multicenter observational included 2458 histologically confirmed collected from 52 centers Turkey. In a central laboratory, codons 12 13 were analyzed using polymerase chain reaction (PCR). Statistical analyses performed chi-square tests Monte Carlo simulations, with significance threshold set at p < 0.05. Results: Depending on region, detected 45% patients, ranging 39.6% 47.5%. The rate was significantly higher female (48.8%) compared male (42.6%) (p = 0.002). Codon more frequent than codon mutations. G12D, G12V, G13D accounted 80% all G12V prevalent 0.007). Based diversity similar, no statistically significant difference found > 0.05). Conclusions: large-scale, provides comprehensive dataset revealed regional trends, well gender differences. findings highlight importance routine genotyping guiding personalized treatment strategies, especially regarding candidate selection therapies. Further research is required elucidate prognostic therapeutic implications specific

Language: Английский

Advances in Molecular Mechanisms and Therapeutic Strategies in Colorectal Cancer: A New Era of Precision Medicine DOI Open Access
Donatella Delle Cave

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 346 - 346

Published: Jan. 2, 2025

Colorectal cancer (CRC) is one of the leading causes cancer-related morbidity and mortality worldwide [...]

Language: Английский

Citations

0
A narrative review on the use of Green synthesized metallic nanoparticles for targeted cancer therapy DOI
Prashant Kumar, Sumel Ashique, Himanshu Sharma

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108305 - 108305

Published: Feb. 23, 2025

Language: Английский

Citations

0
Regional and Gender-Based Distribution of KRAS Mutations in Metastatic Colorectal Cancer Patients in Turkey: An Observational Study DOI Creative Commons
Nurullah İlhan, Faysal Dane, Erdem Göker

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 694 - 694

Published: April 10, 2025

Background and Objectives: KRAS genes are among the most prominent oncogenes that trigger tumor formation in colorectal cancer (CRC) serve as predictive biomarkers for resistance to anti-EGFR therapies metastatic (mCRC) patients. However, prevalence mutation spectrum of gene family mCRC patients Turkey have not been sufficiently analyzed. This study investigates frequency distribution mutations across different regions examines gender-related variations. Materials Methods: multicenter observational included 2458 histologically confirmed collected from 52 centers Turkey. In a central laboratory, codons 12 13 were analyzed using polymerase chain reaction (PCR). Statistical analyses performed chi-square tests Monte Carlo simulations, with significance threshold set at p < 0.05. Results: Depending on region, detected 45% patients, ranging 39.6% 47.5%. The rate was significantly higher female (48.8%) compared male (42.6%) (p = 0.002). Codon more frequent than codon mutations. G12D, G12V, G13D accounted 80% all G12V prevalent 0.007). Based diversity similar, no statistically significant difference found > 0.05). Conclusions: large-scale, provides comprehensive dataset revealed regional trends, well gender differences. findings highlight importance routine genotyping guiding personalized treatment strategies, especially regarding candidate selection therapies. Further research is required elucidate prognostic therapeutic implications specific

Language: Английский

Citations

0