Multifunctional Docetaxel Cholesterol‐Polyethylene Glycol Co‐Modified Poly (N‐Butyl) Cyanoacrylate Nanoparticles for Brain Tumor Therapy DOI
Xiao Hu,

Feifei Yang,

Yonghong Liao

et al.

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(2)

Published: Feb. 27, 2025

ABSTRACT Owing to the presence of blood‐brain barrier and lack significant specificity towards tumor cells after entry into brain, unsuccessful delivery anticancer drugs treatment brain tumors. The hypothesis that cholesterol‐PEG co‐modified poly (N‐butyl) cyanoacrylate nanoparticles (CLS‐PEG NPs) are an effective carrier for tumors was verified, mechanism its preliminarily explored. In this study, we used multifunctional modified with cholesterol polyethylene glycol (PEG) as a drug system encapsulate docetaxel (DTX). Cell anti‐proliferation tests showed CLS‐PEG NPs increased inhibitory effect DTX. A pharmacokinetic study indicated achieved sustained release 8 h. These experimental results demonstrated amplified concentration transported in brain. addition, led better pharmacological efficacy orthotopic glioma rat model. survival rate rats group significantly prolonged 28 d. We also found inhibited M2 microglial polarization. indicate prospective targeting

Language: Английский

Multifunctional Docetaxel Cholesterol‐Polyethylene Glycol Co‐Modified Poly (N‐Butyl) Cyanoacrylate Nanoparticles for Brain Tumor Therapy DOI
Xiao Hu,

Feifei Yang,

Yonghong Liao

et al.

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(2)

Published: Feb. 27, 2025

ABSTRACT Owing to the presence of blood‐brain barrier and lack significant specificity towards tumor cells after entry into brain, unsuccessful delivery anticancer drugs treatment brain tumors. The hypothesis that cholesterol‐PEG co‐modified poly (N‐butyl) cyanoacrylate nanoparticles (CLS‐PEG NPs) are an effective carrier for tumors was verified, mechanism its preliminarily explored. In this study, we used multifunctional modified with cholesterol polyethylene glycol (PEG) as a drug system encapsulate docetaxel (DTX). Cell anti‐proliferation tests showed CLS‐PEG NPs increased inhibitory effect DTX. A pharmacokinetic study indicated achieved sustained release 8 h. These experimental results demonstrated amplified concentration transported in brain. addition, led better pharmacological efficacy orthotopic glioma rat model. survival rate rats group significantly prolonged 28 d. We also found inhibited M2 microglial polarization. indicate prospective targeting

Language: Английский

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