Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review DOI Creative Commons

Lichang Yang,

Wei Wu, Jing Yang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 28, 2025

Immunosenescence, the age-associated decline of immune system, is pivotal in fostering drug resistance within tumor microenvironment (TME). The accumulation senescent cells and release pro-inflammatory senescence-associated secretory phenotype (SASP) factors create a milieu that supports survival undermines therapeutic efficacy. Traditional cancer treatments often fail to address this underlying issue, leading suboptimal outcomes. This article proposes an innovative strategy overcome immunosenescence-induced through nanoparticle-mediated delivery herbal-derived natural products (HDNPs), which possess senolytic immunomodulatory properties capable clearing rejuvenating function. Nanoparticle systems enhance these compounds’ stability, bioavailability, targeted TME cells. By harnessing synergistic effects HDNPs nanotechnology, approach offers novel multifaceted solution therapy. It holds potential restore surveillance, reduce pro-survival signaling cells, efficacy conventional treatments. paradigm shift emphasizes importance addressing immunosenescence as target paves way for more effective personalized interventions.

Language: Английский

A new Clonostachys sp. ZBS49 filamentous fungus with high production of betulinic acid and its inhibitory effect on liver cancer cells DOI Creative Commons
Li Geng,

Jiale Cui,

Changyixin Xiao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Background Triterpenoid compounds such as betulinic acid (BA) and oleanolic (OA) exhibit considerable pharmacological activities. However, their current production primarily relies on plant extraction chemical synthesis, methods that are often plagued by low efficiency, complex processes, environmental concerns. Microbial-based synthesis has emerged one of the most effective approaches for producing BA OA. Results This study presented first identification filamentous fungal strains efficiently synthesizing both The strain ZBS49 is a newly identified species Clonostachys isolated from Gleditsia japonica Miq. (showing 99.82% sequence identity), produced 47.7 mg/L BA. XJ1-1, characterized Colletotrichum gloeosporioides Cannabis sativa L., yielded 65.76 After optimizing culture medium cultivation conditions, yields XJ1-1 increased to 288.97 86.14 mg/L, representing improvements 506% 31%, respectively. Furthermore, we discovered extract significantly inhibited hepatocellular cancer cells (SMMC-7721 HepG2) in dose-dependent manner, with minimum inhibitory concentration 70 µM. Genomic analysis sp. elucidated presence 16 putative genes was related triterpenoid biosynthesis 6 distinct terpene biosynthetic gene clusters. Among 145 CYP450, 5 involved C-28 oxidation were predicted. Conclusions research underscores effectiveness fungi biotechnological platform efficient its derivatives, highlighting potential applications therapy. these findings provide valuable genetic resources establish robust technical theoretical framework utilizing microbial triterpenoids.

Language: Английский

Citations

0
Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review DOI Creative Commons

Lichang Yang,

Wei Wu, Jing Yang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 28, 2025

Immunosenescence, the age-associated decline of immune system, is pivotal in fostering drug resistance within tumor microenvironment (TME). The accumulation senescent cells and release pro-inflammatory senescence-associated secretory phenotype (SASP) factors create a milieu that supports survival undermines therapeutic efficacy. Traditional cancer treatments often fail to address this underlying issue, leading suboptimal outcomes. This article proposes an innovative strategy overcome immunosenescence-induced through nanoparticle-mediated delivery herbal-derived natural products (HDNPs), which possess senolytic immunomodulatory properties capable clearing rejuvenating function. Nanoparticle systems enhance these compounds’ stability, bioavailability, targeted TME cells. By harnessing synergistic effects HDNPs nanotechnology, approach offers novel multifaceted solution therapy. It holds potential restore surveillance, reduce pro-survival signaling cells, efficacy conventional treatments. paradigm shift emphasizes importance addressing immunosenescence as target paves way for more effective personalized interventions.

Language: Английский

Citations

0