Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 352 - 352

Published: March 9, 2025

Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms controlled release profiles, enhancing drug delivery across blood−brain barrier (BBB). The integration nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted prolonged release. Recent advances have demonstrated potential these systems in conditions like Parkinson’s disease, epilepsy, brain tumors. Moreover, printing allows multi-drug combinations personalized formulations that adapt individual patient needs. Novel approaches, including stimuli-responsive systems, on-demand dosing, theragnostics, provide new possibilities real-time monitoring disorders. Despite innovations, challenges remain terms scalability, regulatory approval, long-term safety. future perspectives this suggest its revolutionize treatments offering patient-specific therapies, improved penetration, enhanced outcomes. review discusses current state, applications, nanotechnology treatment, highlighting need further research overcome existing challenges.

Language: Английский

Dimethyl Fumarate Sterically Stabilized Solid Lipid Nanoparticles. Physicochemical properties and in vitro drug release

International Journal of Nanomaterials Nanotechnology and Nanomedicine, Journal Year: 2025, Volume and Issue: 11(1), P. 015 - 026

Published: Jan. 1, 2025

In this work Dimethyl Fumarate (DMF)-loaded and DMF-unloaded Solid Lipid Nanoparticles (SLNs) were developed characterized by Dynamic Light Scattering (DLS), Atomic Force Microscopy (AFM), Scanning Electron (SEM), Differential Calorimetry (DSC), X-ray Diffraction (XRD). vitro release assay was also performed, DMF quantified GC-MS. SLNs prepared a two-step methodology using hot nanoemulsification followed ultrasound irradiation. The results of the mean diameter, polydispersity, zeta potential in range 157 to 525 nm, 0.20 0.6, -30 -7mV, respectively. with spherical elliptical shapes evidenced AFM SEM techniques. XRD DSC analyses revealed strong interaction among SLN components significant loss crystallinity set these structured SLNs. Encapsulation efficiency up 99% loading capacity dependent on O/S ratio has been achieved. could be analyzed first-order kinetics.

Language: Английский