Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration DOI Creative Commons
Huanhuan Wu, Chenyu Li, Hong Yuan

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6463 - 6487

Published: May 1, 2025

Language: Английский

Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies DOI Creative Commons
Jurga Bernatonienė,

Mindaugas Plieskis,

Kęstutis Petrikonis

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 352 - 352

Published: March 9, 2025

Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms controlled release profiles, enhancing drug delivery across blood−brain barrier (BBB). The integration nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted prolonged release. Recent advances have demonstrated potential these systems in conditions like Parkinson’s disease, epilepsy, brain tumors. Moreover, printing allows multi-drug combinations personalized formulations that adapt individual patient needs. Novel approaches, including stimuli-responsive systems, on-demand dosing, theragnostics, provide new possibilities real-time monitoring disorders. Despite innovations, challenges remain terms scalability, regulatory approval, long-term safety. future perspectives this suggest its revolutionize treatments offering patient-specific therapies, improved penetration, enhanced outcomes. review discusses current state, applications, nanotechnology treatment, highlighting need further research overcome existing challenges.

Language: Английский

Citations

0
Dimethyl Fumarate Sterically Stabilized Solid Lipid Nanoparticles. Physicochemical properties and in vitro drug release DOI Open Access

Ferreira da Silva Gisela Bevilacqua Rolfsen,

Daynara D. Souza,

de Souza Moraes Ariana

et al.

International Journal of Nanomaterials Nanotechnology and Nanomedicine, Journal Year: 2025, Volume and Issue: 11(1), P. 015 - 026

Published: Jan. 1, 2025

In this work Dimethyl Fumarate (DMF)-loaded and DMF-unloaded Solid Lipid Nanoparticles (SLNs) were developed characterized by Dynamic Light Scattering (DLS), Atomic Force Microscopy (AFM), Scanning Electron (SEM), Differential Calorimetry (DSC), X-ray Diffraction (XRD). vitro release assay was also performed, DMF quantified GC-MS. SLNs prepared a two-step methodology using hot nanoemulsification followed ultrasound irradiation. The results of the mean diameter, polydispersity, zeta potential in range 157 to 525 nm, 0.20 0.6, -30 -7mV, respectively. with spherical elliptical shapes evidenced AFM SEM techniques. XRD DSC analyses revealed strong interaction among SLN components significant loss crystallinity set these structured SLNs. Encapsulation efficiency up 99% loading capacity dependent on O/S ratio has been achieved. could be analyzed first-order kinetics.

Language: Английский

Citations

0
High-cis astaxanthin nano lipid carrier: Preparation and bioavailability analysis DOI

C. Han,

Xintong Zhang, Chenchen Li

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106780 - 106780

Published: May 1, 2025

Language: Английский

Citations

0
Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration DOI Creative Commons
Huanhuan Wu, Chenyu Li, Hong Yuan

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6463 - 6487

Published: May 1, 2025

Language: Английский

Citations

0