Risk of Developmental Delay in Infants Born to Perinatal COVID-19-Positive Mothers at a Tertiary Care Hospital: A Cross-Sectional Study DOI Creative Commons

Krishna Tejaswi Konduri,

Kirti Joshi

Annals of Child Neurology, Journal Year: 2024, Volume and Issue: 32(4), P. 232 - 237

Published: Sept. 24, 2024

Purpose: Prenatal and perinatal experiences of the mother are known to influence infant development. Maternal exposure coronavirus disease 2019 (COVID-19) during pregnancy has been associated with increased morbidity mother-baby separation. However, developmental outcomes infants born COVID-19-positive mothers remain unclear. This study represents an initial exploratory effort assess risks faced by who tested positive for COVID-19. Methods: cross-sectional involved telephonic interviews screenings 45 infants, aged 9 15 months, were between July 2020 May 2021. The Ages & Stages Questionnaire was used assessment. impacts maternal, separation-related factors on development analyzed. Results: Within population, 28.8% (13 infants) presented a risk delay. gross motor problem-solving domains most frequently impacted. Among studied, prolonged separation period (exceeding 7 days), advanced maternal age, gestational age (preterm birth) higher proportions at delay; however, these associations not statistically significant.Conclusion: suggests that COVID-19 face Factors such as birth, metabolic pregnancy, infant-mother could exacerbate this risk. Future research should prioritize objective assessments long-term follow-up monitor in population.

Language: Английский

Inhibition of NKCC1 Ameliorates Anxiety and Autistic Behaviors Induced by Maternal Immune Activation in Mice DOI Creative Commons
Hailong Zhang, Shu‐Fen Hu,

Shu-Ting Qu

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(3), P. 1851 - 1864

Published: Feb. 28, 2024

Autism spectrum disorder (ASD) is thought to result from susceptibility genotypes and environmental risk factors. The offspring of women who experience pregnancy infection have an increased for autism. Maternal immune activation (MIA) in pregnant animals produces with autistic behaviors, making MIA a useful model However, how causes behaviors not fully understood. Here, we show that NKCC1 critical mediating offspring. We confirmed induced by poly(I:C) during leads further demonstrated showed significant microglia activation, excessive dendritic spines, narrow postsynaptic density (PSD) their prefrontal cortex (PFC). Then, discovered these abnormalities may be caused overexpression offspring’s PFCs. Finally, ameliorated the using PFC microinjection inhibitor bumetanide (BTN) Our findings shed new light on pathological mechanisms autism infection.

Language: Английский

Citations

4
Risk of neurodevelopmental changes in 18-month-old children born to mothers infected with SARS-CoV-2 DOI Creative Commons
L.M.D. Silva,

Maria Luisa de Oliveira Melo,

Matheus Francoy Alpes

et al.

Audiology - Communication Research, Journal Year: 2025, Volume and Issue: 30

Published: Jan. 1, 2025

ABSTRACT Purpose To investigate the risk of child development in 18-month-old children born to mothers who were infected by SARS-CoV-2 virus during pregnancy and identify possible delays indicators. Methods Children between January 2021 August 2021, whose tested positive for COVID-19 pregnancy, participated research. linguistic, motor, cognitive social development, Ages & Stages Questionnaires (ASQ-3) was used five domains: Communication, Gross motor coordination, Fine Problem solving Personal/social. Data described using absolute percentage frequencies mean, standard deviation, minimum, median maximum. analyze association variables interest, Poisson regression model used. Tukey's post-test multiple comparisons. Results The Personal-Social domains, followed coordination Solving best performing. worst performance observed Communication domain, coordination. Prematurity, birth weight, Apgar score need hospitalization after associated with low domains assessed. Conclusion A developmental delay pregnancy. domain greatest loss changes Motor Coordination.

Language: Английский

Citations

0
Risco de alterações no neurodesenvolvimento de crianças de 18 meses nascidas de mães infectadas pela SARS-CoV-2 DOI Creative Commons
L.M.D. Silva,

Maria Luisa de Oliveira Melo,

Matheus Francoy Alpes

et al.

Audiology - Communication Research, Journal Year: 2025, Volume and Issue: 30

Published: Jan. 1, 2025

RESUMO Objetivo Investigar risco de alterações no desenvolvimento infantil crianças 18 meses nascidas mães que foram infectadas pelo vírus SARS-CoV-2 durante a gestação e identificar possíveis atrasos em indicadores desenvolvimento. Métodos Participaram da pesquisa 41 nasceram período janeiro 2021 agosto 2021, cujas testaram positivo para Covid-19 gestação. Para investigação do linguístico, motor, cognitivo social foi utilizado o Ages & Stages Questionnaires nos cinco domínios: Comunicação, Coordenação Motora Ampla, Fina, Resolução Problemas Pessoal/Social. Os dados descritos por meio frequências absolutas percentuais média, desvio padrão, mínimo, mediana máximo. analisar associação entre as variáveis interesse modelo regressão Poisson. O pós-teste Tukey comparações múltiplas. Resultados domínios Pessoal/-Social, Fina Problemas, neste seguimento, os melhor desempenho. pior desempenho observado domínio seguido Ampla. A prematuridade, peso ao nascimento, índice Apgar necessidade internação criança pós-nascimento associadas baixo avaliados. Conclusão Foi atraso contaminadas com maior prejuízo alteração

Citations

0
Management of neonates with maternal prenatal coronavirus infection and influencing factors DOI
İstemi Han Çelik, Aslınur Özkaya Parlakay, Fuat Emre Canpolat

et al.

Pediatric Research, Journal Year: 2023, Volume and Issue: 95(2), P. 436 - 444

Published: Oct. 19, 2023

Language: Английский

Citations

6
Neonatal outcomes of maternal prenatal coronavirus infection DOI
İstemi Han Çelik, Atakan Tanaçan, Fuat Emre Canpolat

et al.

Pediatric Research, Journal Year: 2023, Volume and Issue: 95(2), P. 445 - 455

Published: Dec. 6, 2023

Language: Английский

Citations

6
Maternal and neonatal outcomes during COVID-19 pandemic and pre-pandemic in an urban slum in North India – A community-based ambispective cohort study DOI Creative Commons
Saranya Rajavel,

M Sathiabalan,

Tarundeep Singh

et al.

Journal of Family Medicine and Primary Care, Journal Year: 2024, Volume and Issue: 13(3), P. 977 - 983

Published: March 1, 2024

A BSTRACT Background: Coronavirus disease 2019 (COVID-19) has affected millions of people globally since its first case reported on December in Wuhan, China. The maternal and neonatal outcomes during COVID-19 pandemic were not much low- middle-income countries. Therefore, we aimed to assess the compared them with those pre-pandemic period (i.e., 2019). Materials Methods: We obtained data from cohort pregnant women who delivered period. All registered antenatal mothers resident selected dispensary health care facilities January June 2021 included study for assessing socio-demographic, antenatal, natal, post-natal, new-born characteristics. semi-structed questionnaire was used obtaining details regarding pregnancy status. neuro-development assessment newborn done community using Trivandrum Developmental Screening Chart (TDSC). Chi-square test Fischer exact draw association between pre-COVID-19 P value <0.05 considered statistically significant. Results: total 158 220 pre-COVID COVID, respectively. Out them, 83 (47.4%) (pre-COVID) (76.4%) (during pandemic) contacted. mean age 25 ± 3.9 years. prevalence anemia significantly higher COVID pandemic. proportion Rh-negative other investigation reports similar both groups. high-risk is high among than On applying multivariate analysis, developmental delay at 3 months found be significant children born Conclusion: simple tool development milestones, have that newborns inappropriate milestone post-delivery. However, further research needed neuro-developmental status follow-up comprehensive assessment. It important identify delays associated provide support learning, socialization, physical mental health, family support.

Language: Английский

Citations

1
Maternal COVID-19 infection associated with offspring neurodevelopmental disorders DOI
Lian Duan,

Huamin Yin,

Jiaxin Liu

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Language: Английский

Citations

1
University students’ perception of their dietary behavior through the course of the COVID-19 pandemic: a phenomenological approach DOI
Nivedhitha Parthasarathy, Sheryl McCurdy, Christine Markham

et al.

Journal of American College Health, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 6

Published: Jan. 16, 2024

Purpose The COVID-19 pandemic mandates that were imposed to curb the spread of disease may have triggered unhealthy dietary behaviors among university students. current study aims at exploring students' perception their through course pandemic.

Language: Английский

Citations

0
Desenvolvimento neuropsicomotor de crianças infectadas pelo SARS-CoV-2: revisão sistemática DOI Creative Commons

Alessandra Madalena Garcia Santos,

Aline Dahmer da Silva, Alicia Botello-Hermosa

et al.

DELOS Desarrollo Local Sostenible, Journal Year: 2024, Volume and Issue: 17(53), P. e1299 - e1299

Published: March 1, 2024

Objetivo: Identificar estudos que relacionem a infecção por SARS-CoV-2, na gestação ou primeiro ano pós-parto, com alterações no desenvolvimento neuropsicomotor de crianças. Métodos: Busca realizada em nove bases dados, elegendo publicados, observacionais, crianças infectadas SARS-CoV-2 período gestacional (mães gestação) vida. Os artigos foram inicialmente direcionados ao EndNote Web removendo duplicatas; remanescentes exportados para o Rayyan QCRI. Neste, dois revisores independentes realizaram leitura dos títulos e resumos; os elencados seguiam integral. Aqueles incluídos, passaram avaliação risco viés extração dados. Resultados: Identificou-se 6052 artigos, 3953 seguiram análise título resumo, sendo elegiveis 23 integral; 11 incluídos análise. Cinco relataram nas SARS-CoV-2. Conclusões: Desfecho possíveis prejuízos da contaminação ainda são investigados permanecem incertos. Contudo, sugerem acompanhamento destas

Citations

0
Risk of Developmental Delay in Infants Born to Perinatal COVID-19-Positive Mothers at a Tertiary Care Hospital: A Cross-Sectional Study DOI Creative Commons

Krishna Tejaswi Konduri,

Kirti Joshi

Annals of Child Neurology, Journal Year: 2024, Volume and Issue: 32(4), P. 232 - 237

Published: Sept. 24, 2024

Purpose: Prenatal and perinatal experiences of the mother are known to influence infant development. Maternal exposure coronavirus disease 2019 (COVID-19) during pregnancy has been associated with increased morbidity mother-baby separation. However, developmental outcomes infants born COVID-19-positive mothers remain unclear. This study represents an initial exploratory effort assess risks faced by who tested positive for COVID-19. Methods: cross-sectional involved telephonic interviews screenings 45 infants, aged 9 15 months, were between July 2020 May 2021. The Ages & Stages Questionnaire was used assessment. impacts maternal, separation-related factors on development analyzed. Results: Within population, 28.8% (13 infants) presented a risk delay. gross motor problem-solving domains most frequently impacted. Among studied, prolonged separation period (exceeding 7 days), advanced maternal age, gestational age (preterm birth) higher proportions at delay; however, these associations not statistically significant.Conclusion: suggests that COVID-19 face Factors such as birth, metabolic pregnancy, infant-mother could exacerbate this risk. Future research should prioritize objective assessments long-term follow-up monitor in population.

Language: Английский

Citations

0