The Gustave Roussy Immune score (GRIm score) as a novel prognostic score for early breast cancer patients: A real-world retrospective study DOI Creative Commons
Chunlei Tan, Jinling Xu,

Xiaotian Yang

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2640 - 2654

Published: Jan. 1, 2024

Background and objective: The aim of this research is to investigate whether the GRIm score serves as a novel prognostic tool for predicting survival rates among early breast cancer patients undergoing surgical treatment. Methods: This retrospective study included 313 cases hospitalized in our hospital from January 2015 November 2015. All enrolled received surgery had no metastasis. was based on five objective markers: (1) albumin level (<3.5 g/L = 1 point), (2) LDH (≥245 U/L point); (3) AST-to-ALT ratio (≥1.44 (4) total bilirubin (≥21 μmol/ml (5) NLR (≥1.51 point). best critical value 1.51 by ROC. Patients were categorized into two groups scores: low-score group (0 point) high-score (1 5 points). Kaplan-Meier method log rank test utilized estimate disease free (DFS) overall (OS). Both univariate analysis multivariate Cox used analyze relationship parameters. Nomograms formulated reliant outcomes analysis. Results: Based score, cohort divided groups: with 81 232 cases. mean DFS OS significantly prolonged compared (DFS: 74.39 vs. 66.20 months, χ2=8.729, P=0.0031; OS: 83.71 76.40 P=0.0031). According multivariable analysis, notably correlated (HR: 2.789, 95% CI: 1.304-5.965, P= 0.004) 3.015, 1.409-10.087, P=0.004). exhibited excellent predictive performance (C-index: 0.823) 0.807). Conclusions: assessing prognosis patients. show good prediction ability.

Language: Английский

Prognostic significance of systemic pan-immune-inflammation value in locally advanced cervical cancer DOI Creative Commons
Yan Shu,

Xin Gong,

Rui Liu

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 28, 2024

Objective This study investigates the significance of systemic pan-immune inflammation value (PIV) prior to concurrent chemoradiotherapy (CCRT) in predicting therapeutic efficacy as well prognosis patients with locally advanced cervical squamous cell carcinoma. Methods A retrospective analysis was conducted on clinical data 847 cancer (LACC) treated at Second Hospital Jilin University between 2016 and 2020. All underwent radical CCRT, including platinum-based sensitizing chemotherapy. The PIV measured given by: (platelet count × neutrophil monocyte count)/lymphocyte count. Logistic regression utilized effect response LACC Kaplan–Meier survival together Cox proportional hazard model assess its impact prognosis. Results With endpoint, optimal cutoff (356.0099) signified via receiver operating characteristics curve, were grouped compared based this value. determined an independent predictor CCRT for (hazard ratio (HR) 1.696, 95% confidence interval (CI) 1.111–2.590). also overall (OS) (HR 0.540, CI 0.409–0.713, p&lt;0.001) disease-free (DFS) 0.680, 0.528–0.876, p=0.003). Compared low-PIV group, it noted that individuals a high exhibited poorer shorter OS DFS. Conclusion Patients had outcomes Our results may provide new prognostic biomarker LACC, if future prospective studies large patient numbers support our findings.

Language: Английский

Citations

2
The Gustave Roussy Immune score (GRIm score) as a novel prognostic score for early breast cancer patients: A real-world retrospective study DOI Creative Commons
Chunlei Tan, Jinling Xu,

Xiaotian Yang

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2640 - 2654

Published: Jan. 1, 2024

Background and objective: The aim of this research is to investigate whether the GRIm score serves as a novel prognostic tool for predicting survival rates among early breast cancer patients undergoing surgical treatment. Methods: This retrospective study included 313 cases hospitalized in our hospital from January 2015 November 2015. All enrolled received surgery had no metastasis. was based on five objective markers: (1) albumin level (<3.5 g/L = 1 point), (2) LDH (≥245 U/L point); (3) AST-to-ALT ratio (≥1.44 (4) total bilirubin (≥21 μmol/ml (5) NLR (≥1.51 point). best critical value 1.51 by ROC. Patients were categorized into two groups scores: low-score group (0 point) high-score (1 5 points). Kaplan-Meier method log rank test utilized estimate disease free (DFS) overall (OS). Both univariate analysis multivariate Cox used analyze relationship parameters. Nomograms formulated reliant outcomes analysis. Results: Based score, cohort divided groups: with 81 232 cases. mean DFS OS significantly prolonged compared (DFS: 74.39 vs. 66.20 months, χ2=8.729, P=0.0031; OS: 83.71 76.40 P=0.0031). According multivariable analysis, notably correlated (HR: 2.789, 95% CI: 1.304-5.965, P= 0.004) 3.015, 1.409-10.087, P=0.004). exhibited excellent predictive performance (C-index: 0.823) 0.807). Conclusions: assessing prognosis patients. show good prediction ability.

Language: Английский

Citations

1