Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response DOI Creative Commons
Chunlei Zhang, Yong Wang, Lei Cheng

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 5, 2025

Colorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence tumor immune surveillance responses to immunotherapies chemotherapy in CRC. We highlight role specific microbial taxa promoting or inhibiting growth potential microbiota-based biomarkers for predicting treatment efficacy. The also discusses implications modulation strategies, including diet, probiotics, fecal transplantation, personalized management. By critically evaluating literature, we aim provide comprehensive understanding microbiota’s dual inform future research directions this field.

Language: Английский

The Gut Microbiota and Colorectal Cancer: Understanding the Link and Exploring Therapeutic Interventions DOI Creative Commons
Imen Zalila‐Kolsi, Dhoha Dhieb, Hussam Ali Osman

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 251 - 251

Published: Feb. 28, 2025

CRC remains a significant public health challenge due to its high prevalence and mortality rates. Emerging evidence highlights the critical role of gut microbiota in both pathogenesis efficacy treatment strategies, including chemotherapy immunotherapy. Dysbiosis, characterized by imbalances microbial communities, has been implicated progression therapeutic outcomes. This review examines intricate relationship between composition CRC, emphasizing potential for profiles serve as biomarkers early detection prognosis. Various interventions, such prebiotics, probiotics, postbiotics, fecal transplantation, dietary modifications, aim restore balance shift dysbiosis toward eubiosis, thereby improving Additionally, integration profiling into clinical practice could enhance diagnostic capabilities personalize advancing field oncology. The study intratumoral offers new prognostic tools that, combined with artificial intelligence algorithms, predict responses assess risk adverse effects. Given growing understanding microbiome–cancer axis, developing microbiota-oriented strategies prevention holds promise patient care

Language: Английский

Citations

0
Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response DOI Creative Commons
Chunlei Zhang, Yong Wang, Lei Cheng

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 5, 2025

Colorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence tumor immune surveillance responses to immunotherapies chemotherapy in CRC. We highlight role specific microbial taxa promoting or inhibiting growth potential microbiota-based biomarkers for predicting treatment efficacy. The also discusses implications modulation strategies, including diet, probiotics, fecal transplantation, personalized management. By critically evaluating literature, we aim provide comprehensive understanding microbiota’s dual inform future research directions this field.

Language: Английский

Citations

0