Aging, Cancer, and Inflammation: The Telomerase Connection
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8542 - 8542
Published: Aug. 5, 2024
Understanding
the
complex
dynamics
of
telomere
biology
is
important
in
strong
link
between
aging
and
cancer.
Telomeres,
protective
caps
at
end
chromosomes,
are
central
players
this
connection.
While
their
gradual
shortening
due
to
replication
limits
tumors
expansion
by
triggering
DNA
repair
mechanisms,
it
also
promotes
oncogenic
changes
within
thus
sustaining
tumorigenesis.
The
enzyme
telomerase,
responsible
for
maintaining
length,
emerges
as
a
player
context.
Its
expression
cancer
cells
facilitates
preservation
telomeres,
allowing
them
circumvent
growth-limiting
effects
short
telomeres.
Interestingly,
influence
telomerase
extends
beyond
maintenance,
evidenced
its
involvement
promoting
cell
growth
through
alternative
pathways.
In
context,
inflammation
accelerates
shortening,
resulting
dysfunction,
while
elements
play
role
modulating
inflammatory
response.
recognition
interplay
has
promoted
development
novel
therapeutic
approaches
centered
around
inhibition.
This
review
provides
comprehensive
overview
field,
emphasizing
recent
progress
knowledge
implications
understanding
biology.
Language: Английский
Chronic Inflammation to Cancer: The Impact of Oxidative Stress on DNA Methylation
Frontiers in Bioscience-Landmark,
Journal Year:
2025,
Volume and Issue:
30(3)
Published: March 18, 2025
The
genomic
landscape
of
cancer
cells
is
complex
and
heterogeneous,
with
aberrant
DNA
methylation
being
a
common
observation.
Growing
evidence
indicates
that
oxidants
produced
from
immune
may
interact
epigenetic
processes,
this
represent
mechanism
for
the
initiation
altered
patterns
observed
in
both
precancerous
cancerous
cells.
Around
20%
cancers
are
linked
to
chronic
inflammatory
conditions,
yet
precise
mechanisms
connecting
inflammation
progression
remain
unclear.
During
inflammation,
release
response
stimuli,
which,
high
concentrations,
can
cause
cytotoxic
effects.
Oxidants
known
damage
proteins
disrupt
normal
signalling
pathways,
potentially
initiating
sequence
events
drives
carcinogenesis.
While
research
on
impact
cell-derived
remains
limited,
crucial
link
between
development.
This
review
examines
current
inflammation-associated
changes
related
inflammation.
Language: Английский