Comparative Genomic Analysis of Key Oncogenic Pathways in Hepatocellular Carcinoma Among Diverse Populations DOI Open Access
Cecilia Monge,

Brigette Waldrup,

Francisco Carranza

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(8), P. 1309 - 1309

Published: April 13, 2025

Background/Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with significant racial and ethnic disparities in incidence, tumor biology, clinical outcomes. Hispanic/Latino (H/L) patients tend to be diagnosed at younger ages more advanced stages than Non-Hispanic White (NHW) patients, yet the molecular mechanisms underlying these remain poorly understood. Key oncogenic pathways, including RTK/RAS, TGF-beta, WNT, PI3K, TP53, play pivotal roles progression, treatment resistance, response targeted therapies. However, ethnicity-specific alterations within pathways largely unexplored. This study aims compare pathway-specific mutations HCC between H/L NHW assess mutation burden, identify ethnicity-associated drivers using publicly available datasets. Findings from this analysis may inform precision medicine strategies for improving early detection therapies underrepresented populations. Methods: We conducted bioinformatic datasets frequencies TP53 pathway genes. included 547 consisting 69 478 patients. Patients were stratified by ethnicity (H/L vs. NHW) evaluate differences prevalence. Chi-squared tests used frequencies, while Kaplan–Meier survival assessed overall associated both Results: Significant observed RTK/RAS pathway-related genes, particularly FGFR4 mutations, which prevalent compared (4.3% 0.6%, p = 0.02). Additionally, IGF1R exhibited borderline significance (7.2% 2.9%, 0.07). In PI3K pathway, INPP4B frequent 1%, 0.06), while, TGF-beta TGFBR2 common (2.9% 0.4%, 0.07), suggesting potential variations. Survival revealed no indicating that alone not fully explain role additional factors such as immune response, environmental exposures, or access Conclusions: provides one first ethnicity-focused analyses key HCC, revealing distinct The findings suggest (FGFR4, IGF1R), (INPP4B), (TGFBR2) among their prognostic remains unclear. These insights emphasize importance incorporating profiling into approaches improve detection, therapies, outcomes

Language: Английский

Comparative Genomic Analysis of Key Oncogenic Pathways in Hepatocellular Carcinoma Among Diverse Populations DOI Open Access
Cecilia Monge,

Brigette Waldrup,

Francisco Carranza

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(8), P. 1309 - 1309

Published: April 13, 2025

Background/Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with significant racial and ethnic disparities in incidence, tumor biology, clinical outcomes. Hispanic/Latino (H/L) patients tend to be diagnosed at younger ages more advanced stages than Non-Hispanic White (NHW) patients, yet the molecular mechanisms underlying these remain poorly understood. Key oncogenic pathways, including RTK/RAS, TGF-beta, WNT, PI3K, TP53, play pivotal roles progression, treatment resistance, response targeted therapies. However, ethnicity-specific alterations within pathways largely unexplored. This study aims compare pathway-specific mutations HCC between H/L NHW assess mutation burden, identify ethnicity-associated drivers using publicly available datasets. Findings from this analysis may inform precision medicine strategies for improving early detection therapies underrepresented populations. Methods: We conducted bioinformatic datasets frequencies TP53 pathway genes. included 547 consisting 69 478 patients. Patients were stratified by ethnicity (H/L vs. NHW) evaluate differences prevalence. Chi-squared tests used frequencies, while Kaplan–Meier survival assessed overall associated both Results: Significant observed RTK/RAS pathway-related genes, particularly FGFR4 mutations, which prevalent compared (4.3% 0.6%, p = 0.02). Additionally, IGF1R exhibited borderline significance (7.2% 2.9%, 0.07). In PI3K pathway, INPP4B frequent 1%, 0.06), while, TGF-beta TGFBR2 common (2.9% 0.4%, 0.07), suggesting potential variations. Survival revealed no indicating that alone not fully explain role additional factors such as immune response, environmental exposures, or access Conclusions: provides one first ethnicity-focused analyses key HCC, revealing distinct The findings suggest (FGFR4, IGF1R), (INPP4B), (TGFBR2) among their prognostic remains unclear. These insights emphasize importance incorporating profiling into approaches improve detection, therapies, outcomes

Language: Английский

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