European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)
Published: Nov. 1, 2024
Sepsis-induced myocardial injury (SIMI) is a severe complication of sepsis, contributing significantly to mortality. Mitochondrial dysfunction and dysregulated autophagy are implicated in SIMI pathogenesis. Long non-coding RNA MALAT1 has been associated with various diseases, including but its role remains unclear.
Language: Английский
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(1)
Published: Jan. 1, 2024
Abstract In recent years, the application of engineering nanomaterials has significantly contributed to development various biomedical fields. Zinc oxide (ZnO NMts) have gained wide popularity due their biocompatibility, unique physical and chemical properties, stability, cost‐effectiveness for large‐scale production. They emerged as potential materials anticancer applications. This article provides a comprehensive review synthesis methods ZnO NMts highlights advantages combining with drugs nano platform cancer treatment. Additionally, briefly explains mechanism action in tumor cells, focusing on mitochondrial pathways that target cell apoptosis autophagy. It is observed these are primarily influenced by reactive oxygen species generated through oxidative stress. The discusses promising prospects combined field medicine emphasizes need further in‐depth research autophagy pathways.
Language: Английский
Citations
8
Aging, Journal Year: 2023, Volume and Issue: 15(10), P. 4374 - 4390
Published: May 22, 2023
Objective: Apoptosis and autophagy are significant factors of sepsis induced myocardial injury (SIMI). XBJ improves SIMI by PI3K/AKT/mTOR pathway. Present study is devised to explore the protective mechanism in continuous treatment caused CLP. Methods: Rat survival was first recorded within 7 days. Rats were randomly assigned three groups: Sham group, CLP group. The animals each group divided into 12 h 1 d, 2 3 d 5 according administration time hours, day, days, days or respectively. Echocardiography, markers H&E staining used detect cardiac function injury. IL-1β, IL-6 TNF-α serum measured using ELISA kits. Cardiomyocyte apoptosis assayed TUNEL staining. related proteins regulated signaling pathway tested western blot. Results: increased rate CLP-induced septic Rat. First all, results echocardiography, (cTnI, CK, LDH levels) showed that could effectively improve with increase time. Moreover, significantly decreased levels inflammatory cytokines rats. Meanwhile, downregulated expression apoptosis-related Bax, Cleaved-Caspase 3, 9, Cytochrome C Cleaved-PARP, while upregulated protein Bcl-2 And, Beclin-1 LC3-II/LC3-I ratio rats, whereas P62. Finally, phosphorylation PI3K, AKT mTOR Conclusions: Our has a good effect on after treatment, it speculated might be through inhibiting promoting via, at least partially, activating early stage sepsis, as well via suppressing late sepsis.
Language: Английский
Citations
16
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135970 - 135970
Published: Sept. 26, 2024
Language: Английский
Citations
6
Aging, Journal Year: 2024, Volume and Issue: unknown
Published: April 19, 2024
Aims: This study aimed to evaluate the effects of VC on SIMI in rats. Methods: In this study, survival rate high dose for was evaluated within 7 days. Rats were randomly assigned three groups: Sham group, CLP and (500 mg/kg i.v.) group. The animals each group treated with drugs 1 day, 3 days or 5 days, respectively. Echocardiography, myocardial enzymes HE used detect cardiac function. IL-1β, IL-6, IL-10 TNF-α) serum measured using ELISA kits. Western blot proteins related apoptosis, inflammation, autophagy, MAPK, NF-κB PI3K/Akt/mTOR signaling pathways. Results: High improved staining showed that high-dose relieved rats a time-dependent manner. And compared decreased expressions pro-apoptotic proteins, while increased expression anti-apoptotic protein. phosphorylation levels Erk1/2, P38, JNK, IKK α/β protein Beclin-1 LC3-II/LC3-I ratio, whereas P62 Finally, attenuated PI3K, AKT mTOR Significance: Our results has good protective effect after continuous treatment, which may be mediated by inhibiting apoptosis inflammatory, promoting autophagy through regulating PI3K/AKT/mTOR pathway.
Language: Английский
Citations
4
Aging, Journal Year: 2023, Volume and Issue: 15(16), P. 8501 - 8517
Published: Aug. 30, 2023
Objective: Compelling evidence has demonstrated that Xuebijing (XBJ) exerted protective effects against SIMI. The aims of this study were to investigate whether TLR4/IKKα-mediated NF-κB and JAK2/STAT3 pathways involved in XBJ's cardio-protection during sepsis the mechanisms. Methods: In study, rats randomly assigned three groups: Sham group; CLP XBJ group. Rats treated with or sanitary saline after CLP. Echocardiography, myocardial enzymes HE used detect cardiac function. IL-1β, IL-6 TNF-α serum measured using ELISA kits. Cardiomyocyte apoptosis tested by TUNEL staining. protein levels Bax, Bcl-2, Bcl-xl, Cleaved-Caspase 3, 9, Cleaved-PARP, TLR4, p-NF-κB, p-IKKα, p-JAK2 p-STAT3 myocardium assayed western blotting. And finally, immunofluorescence was assess level heart tissue. Results: results echocardiography, enzyme test showed could significantly improve markedly lower group than (p<0.05). staining's ameliorated CLP-induced cardiomyocyte apoptosis. Meanwhile, downregulated p-STAT3, as well upregulated Bcl-xl (p <0.05). Conclusions: here, we observed cardioprotective advantages may be attributable its ability suppress inflammation via inhibiting TLR4/ IKKα-mediated sepsis.
Language: Английский
Citations
10
EBioMedicine, Journal Year: 2023, Volume and Issue: 96, P. 104810 - 104810
Published: Sept. 25, 2023
Language: Английский
Citations
10
Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 8, 2025
Sepsis-induced myocardial dysfunction (SIMD) involves reversible dysfunction. The use of inotropes can restore adequate cardiac output and tissue perfusion, but conventional inotropes, such as dobutamine adrenaline, have limited efficacy in situations. Levosimendan is a novel inotrope that acts catecholamine-independent manner. However, study results regarding the treatment SIMD with levosimendan are inconsistent, highly controversial. In this review, we summarized therapeutic mechanisms considered recent research on how to improve SIMD. We also analyzed potential limitations for provide ideas future clinical trials application
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 15, 2025
The efficacy of dexmedetomidine (DEX) in treating sepsis-induced myocardial injury (SIMI) remains unclear. In this study, we explored the relationship between DEX use and clinical outcomes patients with SIMI, focusing on dosage treatment duration. retrospective cohort analysis, identified SIMI from Medical Information Mart for Intensive Care IV (MIMIC-IV) database categorized them into non-DEX groups based intensive care unit treatment. baseline bias was reduced through propensity score matching (PSM). primary outcome 28-day mortality, whereas secondary were in-hospital mortality rates at 7 days, 90 1 year. association assessed using Kaplan-Meier analysis Cox proportional hazards models. After PSM, 373 group matched 579 to achieve a balanced distribution covariates. regression model demonstrated significant reduction associated use, yielding hazard ratio (HR) 0.61 (95% confidence interval [CI]: 0.47-0.78, P < 0.001). In-hospital also significantly decreased (HR = 0.43, 95% CI: 0.33-0.57, Lower observed doses >0.4 μg/kg/h, particularly range 0.400-0.612 total >3.113 mg during hospitalization, durations exceeding 72 h improved risk all intervals. Regarding 28 our subgroup analyses indicated interaction Sequential Organ Failure Assessment invasive mechanical ventilation. administration year SIMI. These findings require validation future studies.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114021 - 114021
Published: Jan. 18, 2025
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156689 - 156689
Published: March 1, 2025
Language: Английский
Citations
0