European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)
Published: Nov. 1, 2024
Sepsis-induced myocardial injury (SIMI) is a severe complication of sepsis, contributing significantly to mortality. Mitochondrial dysfunction and dysregulated autophagy are implicated in SIMI pathogenesis. Long non-coding RNA MALAT1 has been associated with various diseases, including but its role remains unclear.
Language: Английский
International Journal of Legal Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Cardiovascular diseases are major causes of morbidity and death worldwide, most cardiac deaths related to ischemic injury the myocardium (myocardial infarction). As underlined in current clinical definition classification myocardial infarctions, not all injuries due ischemia: irreversible injury, ending necrosis, can be induced also by various other factors, such as infections, immune disorders, physical chemical agents, trauma. This is supported studies showing that elevated serum levels troponins, a measure damage, common finding non-ischemic types injury. Forensic pathologists confronted with autopsy findings suggestive should therefore realize both forms observed, only natural but non-natural (intoxications, asphyxia, traumatic iatrogenic deaths, others). Distinguishing these different underlying or circumstances critical, determine cause mechanism death, help investigate often challenging medico-legal scenarios. article reviews broad spectrum violent deaths. From this perspective we propose diagnostic approach forensic pathology context.
Language: Английский
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Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116954 - 116954
Published: April 1, 2025
Language: Английский
Citations
0
Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: April 19, 2025
Sepsis, a severe systemic inflammatory condition triggered by infection, is associated with high morbidity and mortality worldwide. While medical diagnosis treatment have advanced in recent years, specific therapy remains unavailable. Recently, significant progress has been made studying the epigenetic RNA modification N6-methyladenosine (m6A) its core methyltransferase METTL3. The role of m6A sepsis also increasingly elucidated. This review aims to explore pathological mechanisms relationship m6A, focusing on key writer, METTL3, sepsis.
Language: Английский
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Medicine, Journal Year: 2025, Volume and Issue: 104(16), P. e42132 - e42132
Published: April 18, 2025
Sepsis is a life-threatening condition characterized by organ dysfunction resulting from dysregulated host immune response to infection. It associated with high incidence, intricate pathophysiological mechanisms, and rapidly progressive severity, rendering it leading cause of mortality among patients in intensive care units. The Nuclear Factor Erythroid 2-Related 2 (Nrf2) transcription factor pivotal for maintaining cellular redox homeostasis regulating the expression antioxidant cytoprotective genes. Emerging evidence suggests that activation Nrf2 signaling pathway attenuates sepsis-induced inflammatory responses, oxidative stress, dysfunction, thereby improving clinical outcomes. These findings underscore potential as therapeutic target, offering promising avenue development novel interventions aimed at mitigating complications prognosis sepsis.
Language: Английский
Citations
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Intensive Care Research, Journal Year: 2025, Volume and Issue: unknown
Published: May 19, 2025
Abstract Personalized treatment and prognosis improvement of sepsis remain one the most challenging issues in critical care medicine. Whole blood cell-derived inflammatory markers have potential to reflect body’s status, immune function, changes disease condition. This article discusses significant importance whole assessment monitoring patients’ conditions, calling for more attention be paid these markers. will provide a solid basis achieving early precise diagnosis as well personalized stratification.
Language: Английский
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Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115493 - 115493
Published: Sept. 19, 2023
Sepsis, a life-threatening dysregulated status of the host response to infection, can cause multiorgan dysfunction and mortality. Sepsis places heavy burden on cardiovascular system due pathological imbalance hyperinflammation immune suppression. Myocardial injury cardiac caused by aberrant responses pathogens lead cardiomyopathy, one most critical complications sepsis. However, many questions about specific mechanisms characteristics this complication remain be answered. The causes sepsis-induced include abnormal perfusion, myocardial inhibitory substances, autonomic dysfunction, mitochondrial calcium homeostasis dysregulation. fight between acts as trigger for cardiomyopathy. Pyroptosis, form programmed cell death, plays role in progress Toll-like receptors (TLRs) act pattern recognition participate innate pathways that recognize damage-associated molecular patterns well pathogen-associated mediate pyroptosis. Notably, pyroptosis is tightly associated with sepsis septic shock. In line these observations, induction TLR-mediated may promising therapeutic approach treat This review focuses potential roles shed light approach, thus helping prevent control shock disorders improve prognosis patients.
Language: Английский
Citations
8
Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11
Published: Dec. 15, 2023
Sepsis is a clinical syndrome characterized by dysregulated host response to infection, leading life-threatening organ dysfunction. It high-fatality condition associated with complex interplay of immune and inflammatory responses that can cause severe harm vital organs. Sepsis-induced myocardial injury (SIMI), as complication sepsis, significantly affects the prognosis septic patients shortens their survival time. For sake better administrating hospitalized it necessary understand specific mechanisms SIMI. To date, multiple studies have shown programmed cell death (PCD) may play an essential role in offering new strategies insights for therapeutic aspects This review aims elucidate cardiomyocyte’s pathophysiological SIMI, particular focus on classical pathways, key molecules, signaling transduction PCD. will explore cross-interaction between different patterns PCD providing theoretical basis multi-target treatments
Language: Английский
Citations
8
International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(5)
Published: Aug. 23, 2024
Sepsis‑induced myopathy (SIM) is one of the leading causes death in critically ill patients. SIM mainly involves respiratory and skeletal muscles patients, resulting an increased risk lung infection, aggravated failure, prolonged mechanical ventilation hospital stay. also independent factor associated with mortality At present, no effective treatment for has yet been established. However, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach utilized various clinical conditions. A significant body basic research supports efficacy MSCs managing sepsis muscle‑related diseases. This literature review aims to explore relationship between sepsis, well their impact on muscle‑associated Additionally, present discusses potential mechanisms benefits context SIM.
Language: Английский
Citations
2
Analytical Cellular Pathology, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 14
Published: March 20, 2023
Purpose. Long non-coding RNAs (LncRNAs) OIP5-AS1 and miR-25-3p play important roles in myocardial injury, whereas their lipopolysaccharide (LPS)-induced injury remain unknown. The purpose of our study was to investigate the functional mechanisms LPS-induced injury. Methods. Rats H9C2 cells were treated with LPS establish model vivo vitro, respectively. expression levels determined by quantitative reverse transcriptase-polymerase chain reaction. Enzyme-linked immunosorbent assay performed measure serum IL-6 TNF-α. relationship between miR-25-3p/NOX4 luciferase reporter and/or RNA immunoprecipitation assay. apoptosis rate detected flow cytometry, cell viability 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide Western blot detect protein Bax, Bcl-2, caspase3, c-caspase3, NOX4, p-NF-κB p65/NF-κB p65. Results. up-regulated, down-regulated tissues rats LPS-treated cells. Knockdown relieved rats. also inhibited inflammation vivo, which subsequently confirmed vitro experiments. In addition, targeted miR-25-3p. MiR-25-3p mimics reversed effects overexpression on promoting inhibiting viability. Besides, blocked NOX4/NF-κB signalling pathway Conclusion. Silencing lncRNA alleviated regulating
Language: Английский
Citations
6
Inflammation, Journal Year: 2023, Volume and Issue: 46(6), P. 2416 - 2432
Published: Sept. 7, 2023
Language: Английский
Citations
6