Protective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study DOI
Eman Mohamed Faruk, Fatma Ibrahim,

M. M. A. Hassan

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(6)

Published: Nov. 5, 2024

Abstract Introduction About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), bioflavonoid, an antioxidant and scavenger reactive oxygen species scavenger. Objective The current study explored possible protective QRT against mucosal tongue injury caused by CPT-11. Methods included four equal groups: group 1/control, 2/QRT, 3/CPT-11, 4/CPT-11 + QRT. Results CPT-11-induced form non-healed ulcers, absent lingual papillae, mononuclear cells infiltration, marked deposition collagen fibers, overexpression CD86 tumor necrosis factor- α (TNF-α). increased malondialdehyde levels, decreased superoxide dismutase total capacity revealed that there was oxidative stress. Also, countenance Ki-67 Bcl-2 NF-κB. QRT-treated showed complete ulcer healing, with histological features almost like control group, along minimal fiber deposition, reactivity TNF-α improvement stress status molecular results as well. Conclusion possess properties CPT-11-triggered injury.

Language: Английский

Neuroprotective effects of quercetin on hippocampal CA1 neurons following middle cerebral artery ischemia‒reperfusion in male rats: a behavioral, biochemical, and histological study DOI Creative Commons

Mehran Mahyar,

Erfan Ghadirzadeh,

Pedram Nezhadnaderi

et al.

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 6, 2025

Abstract Introduction Cerebral ischemic strokes cause brain damage, primarily through inflammatory factors. One of the regions most affected by middle cerebral artery occlusion (MCAO) is hippocampus, specifically CA1 area, which highly susceptible to ischemia. Previous studies have demonstrated anti-inflammatory properties quercetin. Therefore, this study aimed investigate neuroprotective effects quercetin on hippocampal neurons following MCAO. Materials and methods Fifty-six male Albino Wistar rats were divided into seven groups (intact, sham, stroke, vehicle, three quercetin-treated receiving 5, 10, 20 mg/kg, respectively), each containing 8 rats. Various assessments, including water content, rotarod test, Bederson neurological score, Morris maze (MWM) shuttle box histopathological evaluations, measurements interleukin-10 (IL-10) interleukin-1β (IL-1β) levels, conducted across groups. Results Compared with control rats, 5 10 mg/kg presented significant improvements in function, motor function improved performance MWM tests. Histopathological analyses revealed better preservation these Additionally, IL-10 levels significantly increased, whereas IL-1β decreased. However, group showed no statistically changes parameters assessed ( P > 0.05). Conclusion Quercetin may help prevent or ameliorate injuries caused acute suggesting its effects. The reduction increase play key roles quercetin’s protective mechanism.

Language: Английский

Citations

1
Flavonoids serve as a promising therapeutic agent for ischemic stroke DOI
Hongxin Shu,

Qiuye Liao,

Zhihao Chen

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149528 - 149528

Published: Feb. 1, 2025

Language: Английский

Citations

0
Anti-Inflammatory Potential of Quercetin: From Chemistry and Mechanistic Insight to Nanoformulations DOI Creative Commons
Diwakar Aggarwal, Mayank Chaudhary, S. K. Mandotra

et al.

Current Research in Pharmacology and Drug Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100217 - 100217

Published: March 1, 2025

Language: Английский

Citations

0
Flavonoids in the regulation of microglial-mediated neuroinflammation; focus on fisetin, rutin, and quercetin DOI

Mohannad Hamid Jasim,

Rosull Saadoon Abbood,

Gaurav Sanghvi

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114537 - 114537

Published: March 1, 2025

Language: Английский

Citations

0
Neuroprotective effects of Hibiscus sabdariffa var. altissima on cerebral ischemia‒Reperfusion injury in rats DOI Creative Commons
Adjia Hamadjida,

Saida Nkuketgnigni Njemguie,

Rigobert Espoir Ayissi Mbomo

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 12, P. 100485 - 100485

Published: Aug. 2, 2024

Hibiscus sabdariffa var. altissima, which is known for its high-quality fiber, commonly used in Traditional Chinese Medicine (TCM) diuretic, choleretic, analgesic, antitussive, and hypotensive effects. Furthermore, the flowers have been to treat diabetes, hypertension, atherosclerosis, obesity. However, there are no studies assessing neuroprotective effects on cerebral ischemia, unlike variety Therefore, this study was aimed investigate potential efficacy of altissima extract (HAS) underlying mechanism oxidative stress neuroinflammation during ischemia-reperfusion (I/R) injury. A model ischemia established male Wistar rats through middle artery occlusion (MCAO) reperfusion. Rats were randomly divided into sham, IR, IR + HSA100, HSA200, HSA400 Eda groups treated 14 consecutive days. The neurological deficit score cylinder test performed assess impairment. Oxidative determined by measuring levels malondialdehyde (MDA) antioxidant markers such as reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) measured evaluate activities. In addition, inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), also determined. Our results demonstrated that HSA significantly ameliorated impairment volume brain infarct. decreased MDA enhanced activities GSH, SOD CAT tissues. expression proinflammatory cytokines TNF-α, IL-1β IL-6 serum. These findings exhibited a effect against I/R injury, possibly improving attenuating responses. could be therapeutic option ischemic injuries.

Language: Английский

Citations

0
Protective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study DOI
Eman Mohamed Faruk, Fatma Ibrahim,

M. M. A. Hassan

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(6)

Published: Nov. 5, 2024

Abstract Introduction About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), bioflavonoid, an antioxidant and scavenger reactive oxygen species scavenger. Objective The current study explored possible protective QRT against mucosal tongue injury caused by CPT-11. Methods included four equal groups: group 1/control, 2/QRT, 3/CPT-11, 4/CPT-11 + QRT. Results CPT-11-induced form non-healed ulcers, absent lingual papillae, mononuclear cells infiltration, marked deposition collagen fibers, overexpression CD86 tumor necrosis factor- α (TNF-α). increased malondialdehyde levels, decreased superoxide dismutase total capacity revealed that there was oxidative stress. Also, countenance Ki-67 Bcl-2 NF-κB. QRT-treated showed complete ulcer healing, with histological features almost like control group, along minimal fiber deposition, reactivity TNF-α improvement stress status molecular results as well. Conclusion possess properties CPT-11-triggered injury.

Language: Английский

Citations

0