Discovery of a Potent, Highly Selective, and In Vivo Anti-inflammatory Efficacious, P2Y6R Antagonist with a Novel Quinoline-pyrazole Scaffold

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116890 - 116890

Published: Sept. 23, 2024

Language: Английский

---

5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

Acute lung injury (ALI) induced by lipopolysaccharide (LPS) is a significant medical condition characterized severe pulmonary inflammation and tissue damage. NLRP3 inflammasome-driven essential in ALI pathogenesis, inspiring novel therapeutic strategies that focus on inflammation. In this study, we investigated the potential of 5-deoxy-rutaecarpine (5-DR), rutaecarpine derivative, attenuating LPS-induced ALI. evaluated effects 5-DR treatment mice exposed to LPS, tissues, bronchoalveolar lavage fluid, serum were collected for analysis. LPS-stimulated J774A.1 mouse macrophages used further investigate anti-inflammatory vitro. Various techniques including histopathology, Western blotting, luciferase reporter assay employed. significantly reduced edema, inflammatory cell infiltration with LPS burden, levels mediators like interleukin-1β macrophages. Further western blotting analysis showed decreased NLRP3, cleaved caspase-1, mature IL-1β cells LPS. Additionally, NF-κB pathway activation diminished inhibition inflammasome 5-DR. Our findings highlight as promising candidate treating ALI, offering insights into its underlying mechanism targets inflammasome-mediated

Language: Английский

---

Targeting neutrophil dysfunction in acute lung injury: insights from active components of Chinese medicine

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156664 - 156664

Published: March 1, 2025

Language: Английский

---

Exploring the mitigating potential of anthocyanin Malvidin in a mouse model of bleomycin-induced pulmonary fibrosis by inhibiting NLRP3 inflammasome activation and oxidative stress

Journal of Inflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 31, 2025

Malvidin (MV), an essential anthocyanin, has antioxidant and anti-inflammatory effects that may help treat pulmonary fibrosis (PF), a progressive occasionally fatal condition characterized by severe lung scarring, oxidative stress, inflammation. This study aims to evaluate the therapeutic potential of MV in PF assessing its on inflammation, fibrotic markers through vitro vivo models. The compound was evaluated molecular docking. BEAS-2B RLE-6TN cells were treated with 200 µg/mL BLM induce followed treatment. Cell viability, ROS levels, wound healing analyzed. In vivo, BLM-induced mice assess biomarkers. interacted NLRP3 binding energy -7 kcal/mol. increased cell viability cells, reducing stress. Wound enhanced MV-treated groups. A decrease HYP proteins confirms MV's antifibrotic effects. model, reduced TXNIP, MDA, MPO while increasing CAT, GSH, SOD, confirming capacity. alleviated model via inflammasome pathway, demonstrating as agent.

Language: Английский

---

Novel β-γ′ type lignans from cultivated Notopterygium incisum and their potential anti-inflammatory activity

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 229, P. 120944 - 120944

Published: April 5, 2025

Language: Английский

---

NLRP3 Inflammasome-mediated pyroptosis in acute lung injury: Roles of main lung cell types and therapeutic perspectives

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114560 - 114560

Published: April 7, 2025

Language: Английский

---

Effects of remote ischemic preconditioning and/or erythropoietin on lung injury induced by skeletal ischemia reperfusion: role of the NLRP3 inflammasome

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: April 24, 2025

Language: Английский

---