Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105307 - 105307
Published: May 1, 2025
Language: Английский
Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103580 - 103580
Published: March 5, 2025
Despite the increasing recognition of interplay between depression and cardiovascular disease (CVD), precise mechanisms by which contributes to pathogenesis remain inadequately understood. The involvement gut microbiota their metabolites health susceptibility has been gaining attention. In this study, it was found that exacerbated cardiac injury, impaired function (EF%: P < 0.01; FS%: 0.05), hindered long-term survival (P 0.01), intensified adverse remodeling (WGA: MASSON: 0.0001) after myocardial ischemia/reperfusion (MI/R) in mice. Then we mice receiving transplants from chronic social defeat stress (CSDS) exhibited worse 0.01) than those non-CSDS MI/R injury. Moreover, tryptophan metabolism due alterations composition structure observed CSDS Mechanistically, analyzed metabolomics fecal serum samples identified indole-3-propionic acid (IPA) as a protective agent for cardiomyocytes against ferroptosis via NRF2/System xc-/GPX4 axis, played role mediating detrimental influence on MI/R. Our findings provide new insights into IPA CVD, forming basis intervention strategies aimed at mitigating deterioration following patients experiencing depression.
Language: Английский
Citations
1
Life Metabolism, Journal Year: 2025, Volume and Issue: 4(2)
Published: Jan. 29, 2025
Abstract Platelet hyperreactivity contributes significantly to thrombosis in acute myocardial infarction and stroke. While antiplatelet drugs are used, residual ischemic risk remains. Intermittent fasting (IF), a dietary pattern characterized by alternating periods of eating fasting, has shown cardiovascular benefits, but its effect on platelet activation is unclear. This study demonstrates that IF inhibits both patients with coronary artery disease apolipoprotein E (ApoE) knockout (ApoE−/−) mice, enhancing intestinal flora production indole-3-propionic acid (IPA). Mechanistically, elevated IPA plasma directly attenuates binding the pregnane X receptor (PXR) suppressing downstream signaling pathways, including Src/Lyn/Syk LAT/PLCγ/PKC/Ca2+. Importantly, alleviates cerebral ischemia/reperfusion injury ApoE−/− mice. These findings suggest mitigates atherosclerosis IPA, which subsequently activates PXR-related pathways.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Inflammation, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Diabetic kidney disease (DKD) is one of the most severe complications diabetes mellitus, with limited effective therapeutic interventions. Alternate-day fasting (ADF) shows potential in treating DKD, though its mechanisms are not fully understood. In this study, BTBR ob/ob mice underwent 12 weeks ADF, and high-resolution untargeted metabolomics were performed to uncover underlying mechanisms. After exhibited weight loss, lower blood glucose LDL-C levels, reduced 24-h urinary protein excretion, decreased renal collagen deposition. A total 44 metabolites differentially expressed, 25 up-regulated 19 down-regulated. Notably, hyocholic acid (HCA) indole-3-propionic (IPA), both products intestinal bacteria, can modulating inflammation expressed. Furthermore, kidneys showed significantly NF-κB pathway activity after ADF. This study indicates that ADF may alleviate DKD progression by HCA, IPA, decreasing inflammation.
Language: Английский
Citations
0
Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105307 - 105307
Published: May 1, 2025
Language: Английский
Citations
0