Microenvironment of diabetic foot ulcers: Implications for healing and therapeutic strategies DOI Creative Commons
Jiuju Wang, Xuejiao Yang, Tao Zhou

et al.

Journal of Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 1, 2025

Diabetic foot ulcers (DFUs) are a common yet serious complication in individuals with diabetes, often presenting as chronic, nonhealing wounds that significantly impair quality of life. The healing process DFUs is largely influenced by the local microenvironment, which encompasses factors such hypoxia, inflammation, and involvement various cell types. Poor blood circulation affected area results compromising cellular function restricting nutrient supply, thereby delaying wound healing. In addition, chronic inflammation disrupts immune system balance, excessive pro-inflammatory cytokines not only failing to facilitate tissue repair but also exacerbating damage. Moreover, key types, including fibroblasts, keratinocytes, macrophages, play crucial roles at different stages process, contributing collagen production skin regeneration. A comprehensive understanding complex dynamics within DFU microenvironment essential for developing more precise therapeutic approaches, advanced drug delivery systems bioactive materials, aimed promoting reducing risk recurrence.

Language: Английский

Microenvironment of diabetic foot ulcers: Implications for healing and therapeutic strategies DOI Creative Commons
Jiuju Wang, Xuejiao Yang, Tao Zhou

et al.

Journal of Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 1, 2025

Diabetic foot ulcers (DFUs) are a common yet serious complication in individuals with diabetes, often presenting as chronic, nonhealing wounds that significantly impair quality of life. The healing process DFUs is largely influenced by the local microenvironment, which encompasses factors such hypoxia, inflammation, and involvement various cell types. Poor blood circulation affected area results compromising cellular function restricting nutrient supply, thereby delaying wound healing. In addition, chronic inflammation disrupts immune system balance, excessive pro-inflammatory cytokines not only failing to facilitate tissue repair but also exacerbating damage. Moreover, key types, including fibroblasts, keratinocytes, macrophages, play crucial roles at different stages process, contributing collagen production skin regeneration. A comprehensive understanding complex dynamics within DFU microenvironment essential for developing more precise therapeutic approaches, advanced drug delivery systems bioactive materials, aimed promoting reducing risk recurrence.

Language: Английский

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