Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 495, P. 117199 - 117199
Published: Dec. 8, 2024
Language: Английский
Published: Jan. 10, 2025
Review AMPK-Mediated Multi-Organ Protective Effects of GLP-1 Receptor Agonists Xin Wang 1 and Linxi 2,* Emergency Department, Fujian Medical University Union Hospital, Fuzhou 350001, China 2 Department Endocrinology Metabolism, Institute Endocrinology, * Correspondence: [email protected] Received: 11 October 2024; Revised: 23 Accepted: 20 December Published: 9 January 2025 Abstract: AMP-activated protein kinase (AMPK) is a key enzyme broadly involved in regulating cellular metabolism, often called an “energy sensor”. Activated AMPK promotes ATP production storage within cells, primarily by inhibiting ATP-consuming anabolic processes (such as protein, lipid, ribosomal synthesis) initiating ATP-producing catabolic pathways fatty acid oxidation glycolysis) to maintain energy homeostasis. regulates metabolic various peripheral tissues, including glucose lipid cholesterol metabolism pancreatic β-cells, the cardiovascular system, liver, kidneys, skeletal muscles, central nervous system. As antidiabetic drug, multi-organ protective effects Glucagon-like peptide-1 receptor agonists (GLP-1RA) are increasingly being recognized. This paper reviews mechanisms which GLP-1RA confers organ protection via signaling pathway.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 15, 2025
Acute kidney injury (AKI) has become a disease of global concern due to its high morbidity and mortality. This highlighted the need for renoprotective agents. Astragaloside IV (AS-IV) is saponin isolated from Astragalus membranaceus with good antioxidant, anti-inflammatory anti-tumor properties. In this study, HK2 cells rat model were utilized explore protective effect AS-IV against cadmium chloride-induced oxidative stress-induced apoptosis. CdCl2-induced apoptosis, ROS production, mitochondrial membrane potential alterations significantly inhibited in -treated cells. Expression mitochondria-associated apoptotic proteins Cleaved-Caspase3, Cleaved-Caspase9, Cleaved-PARP was reduced after intervention. addition, Rat weight loss also alleviated symptoms nephrotoxicity injury. Further experiments showed that suppresses heavy metal Cd-induced mitochondria-mediated apoptosis by regulating Nrf2/HO-1 pathway. conclusion, could protect metal-induced toxicity be used as nephroprotective agent.
Language: Английский
Citations
0
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177494 - 177494
Published: March 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
Electrical stimulation (ES) serves as a biological cue that regulates critical cellular processes, including proliferation and migration, offering an effective approach to accelerating wound healing. Thermoelectrics, capable of generating electricity by exploiting the temperature difference between skin surrounding environment without external energy input, present promising avenue for ES-based therapies. Herein, we developed Ag2Se@gelatin methacrylate (Ag2Se@GelMA) thermoelectric hydrogels with high room-temperature performance employed them self-powered ES devices repair. Systematic in vivo vitro investigations elucidated their mechanisms enhancing Our findings reveal Ag2Se@GelMA can significantly accelerate closure amplifying endogenous electric field, thereby promoting cell proliferation, angiogenesis. Comprehensive experiments demonstrated generated activates voltage-gated calcium ion channels, elevating intracellular Ca2+ levels mitochondrial functions through Ca2+/CaMKKβ/AMPK/Nrf2 pathway. This cascade improves dynamics angiogenesis, tissue regeneration. The newly represent marked progress dressing technology potential improve clinical strategies engineering regenerative medicine.
Language: Английский
Citations
0
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Drug Development Research, Journal Year: 2025, Volume and Issue: 86(3)
Published: April 28, 2025
ABSTRACT Idiopathic pulmonary fibrosis is a progressive, irreversible lung disease of unknown cause, characterized by gradual thickening and scarring tissue, impairing oxygen transfer into the bloodstream. As result, symptoms such as shortness breath, fatigue, persistent dry cough occur. Currently, FDA‐approved antifibrotic agents Pirfenidone Nintedanib can slow progression disease. However, these treatments cannot completely stop loss function do not provide significant improvement in quality life patients. progresses, capacity decreases, breath increases, general health deteriorates significantly. Therefore, new more effective, targeted therapies that halt IPF are urgently needed. This review addresses novel strategies to or disease‐related targeting key mechanisms involved pathogenesis IPF. The molecular structure–activity relationships (SARs) synthesized compounds JAK/STAT, TGF‐β/Smad, Wnt/β‐catenin, PI3K, JNK1, other critical signaling pathways were examined. These approaches have great potential for development potent selective therapeutic treatment insights provided this may contribute future efficient drugs.
Language: Английский
Citations
0
Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 495, P. 117199 - 117199
Published: Dec. 8, 2024
Language: Английский
Citations
0