Insights into the mechanisms of angiogenesis in hepatoblastoma DOI Creative Commons
Meng Kong,

Yunpeng Zhai,

Hongzhen Liu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: May 14, 2025

Hepatoblastoma (HB), the most common pediatric liver malignancy, is characterized by aggressive growth and metastasis driven complex angiogenic mechanisms. This review elucidates pivotal role of angiogenesis in HB progression, emphasizing metabolic reprogramming, tumor microenvironment (TME) dynamics, oncogenic signalling pathways. The Warburg effect cells fosters a hypoxic microenvironment, stabilizing hypoxia-inducible factor-1α (HIF-1α) upregulating vascular endothelial factor (VEGF), which synergistically enhances angiogenesis. Key pathways such as Wnt/β-catenin, VEGF, PI3K/AKT, JAK2/STAT3 are central to cell proliferation, migration, maturation, whereas interactions with tumor-associated macrophages (TAMs) pericytes further remodel TME support neovascularization. Long noncoding RNAs glycolytic enzymes have emerged critical regulators angiogenesis, linking activity expansion. Anti-angiogenic therapies, including VEGF inhibitors pathway-targeting agents, show preclinical promise but face challenges resistance off-target effects. Future directions advocate for dual-target strategies, spatial multiomics technologies map metabolic–angiogenic crosstalk, personalized approaches leveraging biomarkers risk stratification. synthesis underscores need interdisciplinary collaboration translate mechanistic insights into durable ultimately improving outcomes patients.

Language: Английский

Insights into the mechanisms of angiogenesis in hepatoblastoma DOI Creative Commons
Meng Kong,

Yunpeng Zhai,

Hongzhen Liu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: May 14, 2025

Hepatoblastoma (HB), the most common pediatric liver malignancy, is characterized by aggressive growth and metastasis driven complex angiogenic mechanisms. This review elucidates pivotal role of angiogenesis in HB progression, emphasizing metabolic reprogramming, tumor microenvironment (TME) dynamics, oncogenic signalling pathways. The Warburg effect cells fosters a hypoxic microenvironment, stabilizing hypoxia-inducible factor-1α (HIF-1α) upregulating vascular endothelial factor (VEGF), which synergistically enhances angiogenesis. Key pathways such as Wnt/β-catenin, VEGF, PI3K/AKT, JAK2/STAT3 are central to cell proliferation, migration, maturation, whereas interactions with tumor-associated macrophages (TAMs) pericytes further remodel TME support neovascularization. Long noncoding RNAs glycolytic enzymes have emerged critical regulators angiogenesis, linking activity expansion. Anti-angiogenic therapies, including VEGF inhibitors pathway-targeting agents, show preclinical promise but face challenges resistance off-target effects. Future directions advocate for dual-target strategies, spatial multiomics technologies map metabolic–angiogenic crosstalk, personalized approaches leveraging biomarkers risk stratification. synthesis underscores need interdisciplinary collaboration translate mechanistic insights into durable ultimately improving outcomes patients.

Language: Английский

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