Chondroitin sulfate nanoparticles based on co-delivery dual drug induced ferroptosis in lung cancer cells by disrupting mitochondrial oxidative homeostasis

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101632 - 101632

Published: March 5, 2025

Language: Английский

Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 573 - 573

Published: April 26, 2025

Background: Spinal cord injury (SCI) is a devastating neurological condition with limited therapeutic options. Current clinical interventions predominantly rely on prolonged or high-dose pharmacological regimens, often causing systemic toxicity and adverse events. Although black phosphorus nanosheets (BPNSs) exhibit remarkable reactive oxygen species (ROS)-scavenging capacity to mitigate oxidative damage, their rapid degradation severely compromises efficacy. Methods: This study presents thermosensitive hydrogel gelation properties by incorporating different proportions concentrations of sodium alginate (SA) into chitosan/β-glycerophosphate (CS/β-GP) loading it BPNS for the treatment SCI in rats. In vitro, physical composite were characterized cytotoxicity ROS scavenging abilities assessed using PC12 cells; vivo, behavioral tests, histopathological analysis, transcriptomics, immunohistochemistry, Western blotting performed explore effects mechanisms. Results: The results demonstrate that this effectively slows degradation, exhibits high capacity, reduces lipid peroxidation, thereby inhibits ferroptosis apoptosis, offering neuroprotective promoting motor function recovery. Conclusions: Our findings establish CS/β-GP/SA-BPNS as multifunctional platform SCI, synergizing sustained drug release ROS–ferroptosis–apoptosis axis modulation achieve neuroprotection functional restoration. strategy provides translatable paradigm combining nanotechnology biomaterial engineering neural repair.

Language: Английский

Targeting oxidative stress, iron overload and ferroptosis in bone-degenerative conditions

Turkish Journal of Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Introduction Bone-degenerative conditions, including osteoporosis, rheumatoid arthritis, and osteoarthritis, are major public health concerns worldwide, associated with oxidative stress iron overload that disrupts bone homeostasis. Ferroptosis, an iron-mediated form of cell death, has emerged as a critical factor in degeneration, necessitating comprehensive review its role these conditions. Content This comprehensively examined the latest research on stress, metabolism, ferroptosis related to biology focusing their interconnections potential therapeutic implications. The revealed affects various types, osteoclasts, osteoblasts, chondrocytes, contributing loss cartilage degradation. Iron homeostasis was found be crucial for function, both deficiency potentially leading pathological Ferroptosis regulation involves complex interplay between lipid peroxidation, antioxidant systems, SLC7A11-GSH-GPX4 network FSP1-CoQ10H2 pathway. Different lineages, mesenchymal stem cells, exhibit varied responses induction regulation. Summary Understanding molecular mechanisms underlying cells offers promising avenues developing targeted therapies bone-degenerative Outlook Future should focus elucidating specific roles different disorders exploring interventions targeting overload, pathways improve management debilitating

Language: Английский