Relationship Between Epicardial Adipose Tissue and Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction DOI Open Access
Oğuzhan Yücel

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Introduction and aim: Heart failure with preserved ejection fraction (HFpEF) is a significant clinical challenge, often coexisting atrial fibrillation (AF), which exacerbates patient outcomes by increasing risks of stroke, hospitalizations, mortality. Recent studies suggest that epicardial adipose tissue (EAT), metabolically active fat depot, may contribute to AF pathogenesis promoting remodeling fibrosis. This study aimed evaluate the relationship between EAT thickness in HFpEF patients. Materials methods: A total 110 patients were included, 20 (18.2%) having documented AF. was measured using transthoracic echocardiography, confirmed via electrocardiography. Results: Patients had significantly greater compared those without (8.3 ± 0.9 mm vs. 7.1 0.8 mm, p < 0.001). Receiver operating characteristic (ROC) analysis demonstrated strong predictor (AUC = 0.87, 0.001), cut-off value 7.5 achieving 89% sensitivity 75% specificity. Conclusion: These findings indicate increased independently associated patients, highlighting its potential as biomarker for risk stratification. Future should explore whether targeting could improve this high-risk population.

Language: Английский

Elevated C-reactive protein and cardiovascular risk DOI
Jia Ee Chia, Song Peng Ang

Current Opinion in Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Purpose of review This critically examines the evolving role C-reactive protein (CRP) in cardiovascular disease (CVD), addressing its pathogenesis and relationship with various CVDs including coronary artery (CAD), heart failure, atrial fibrillation. Recent findings CRP is mechanistically implicated endothelial dysfunction, oxidative stress, plaque destabilization. studies demonstrate that lipid-lowering agents (statins, bempedoic acid) anti-inflammatory therapies (canakinumab, colchicine) reduce levels improve outcomes CAD. In elevated predicts adverse events, though evidence on phenotypes varies, novel (glucagon-like peptide-1 agonists, sodium-glucose cotransporter-2 inhibitors) lower independently weight loss. For fibrillation, correlates postoperative incidence recurrence postablation, data remain inconsistent. Guidelines offer differing opinion American College Cardiology Heart Association (ACC/AHA) guidelines cautiously endorsing for risk stratification intermediate-risk individuals, while European advise against routine use primary prevention, reflecting unresolved questions about CRP's additive value. Summary remains a pivotal inflammation biomarker CVD, yet causal clinical applicability require clarification. While CRP-guided show promise, discrepancies highlight need robust trials to determine whether targeting directly improves outcomes. Future research should focus pathophysiological mechanisms validate utility personalized CVD management.

Language: Английский

Citations

1
Relationship Between Epicardial Adipose Tissue and Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction DOI Open Access
Oğuzhan Yücel

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Introduction and aim: Heart failure with preserved ejection fraction (HFpEF) is a significant clinical challenge, often coexisting atrial fibrillation (AF), which exacerbates patient outcomes by increasing risks of stroke, hospitalizations, mortality. Recent studies suggest that epicardial adipose tissue (EAT), metabolically active fat depot, may contribute to AF pathogenesis promoting remodeling fibrosis. This study aimed evaluate the relationship between EAT thickness in HFpEF patients. Materials methods: A total 110 patients were included, 20 (18.2%) having documented AF. was measured using transthoracic echocardiography, confirmed via electrocardiography. Results: Patients had significantly greater compared those without (8.3 ± 0.9 mm vs. 7.1 0.8 mm, p < 0.001). Receiver operating characteristic (ROC) analysis demonstrated strong predictor (AUC = 0.87, 0.001), cut-off value 7.5 achieving 89% sensitivity 75% specificity. Conclusion: These findings indicate increased independently associated patients, highlighting its potential as biomarker for risk stratification. Future should explore whether targeting could improve this high-risk population.

Language: Английский

Citations

0