Decoding mechanisms and protein markers in lung-brain axis DOI Creative Commons
Shiqian Huang, Yuxi Zhou, Haipeng Ji

et al.

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 19, 2025

The lung-brain axis represents a complex bidirectional communication network that is pivotal in the crosstalk between respiratory and neurological functions. This review summarizes current understanding of mechanisms protein markers mediate effects lung diseases on brain health. In this review, we explore linking injury to neurocognitive impairments, focusing neural pathways, immune regulation inflammatory responses, microorganism hypoxemia. Specifically, highlight role vagus nerve modulating central nervous system response pulmonary stimuli; Additionally, regulatory function underscored, with evidence suggesting lung-derived mediators can traverse blood-brain barrier, induce neuroinflammation cognitive decline; Furthermore, discuss potential microbiota influence through microbial translocation activation; Finally, impact hypoxemia examined, findings indicating it exacerbate cerebral via oxidative stress impaired perfusion. Moreover, analyze how conditions, such as pneumonia, ALI/ARDS, asthma, contribute dysfunction. Prolonged mechanical ventilation also impairment. Conversely, (e.g., stroke, traumatic injury) lead acute complications. addition, TLR4, ACE2, A-SAA, HMGB1, TREM2 are crucial correlate disease severity. We emerging therapeutic strategies targeting axis, including immunomodulation microbiome engineering. Overall, interplay for developing integrated treatment improving patient outcomes. Further research needed elucidate molecular foster interdisciplinary collaboration.

Language: Английский

Decoding mechanisms and protein markers in lung-brain axis DOI Creative Commons
Shiqian Huang, Yuxi Zhou, Haipeng Ji

et al.

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 19, 2025

The lung-brain axis represents a complex bidirectional communication network that is pivotal in the crosstalk between respiratory and neurological functions. This review summarizes current understanding of mechanisms protein markers mediate effects lung diseases on brain health. In this review, we explore linking injury to neurocognitive impairments, focusing neural pathways, immune regulation inflammatory responses, microorganism hypoxemia. Specifically, highlight role vagus nerve modulating central nervous system response pulmonary stimuli; Additionally, regulatory function underscored, with evidence suggesting lung-derived mediators can traverse blood-brain barrier, induce neuroinflammation cognitive decline; Furthermore, discuss potential microbiota influence through microbial translocation activation; Finally, impact hypoxemia examined, findings indicating it exacerbate cerebral via oxidative stress impaired perfusion. Moreover, analyze how conditions, such as pneumonia, ALI/ARDS, asthma, contribute dysfunction. Prolonged mechanical ventilation also impairment. Conversely, (e.g., stroke, traumatic injury) lead acute complications. addition, TLR4, ACE2, A-SAA, HMGB1, TREM2 are crucial correlate disease severity. We emerging therapeutic strategies targeting axis, including immunomodulation microbiome engineering. Overall, interplay for developing integrated treatment improving patient outcomes. Further research needed elucidate molecular foster interdisciplinary collaboration.

Language: Английский

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