Unraveling the effects of the Ebola experience on behaviour choices during COVID-19 in Liberia: A mixed methods study across successive outbreaks DOI Creative Commons
Laura Skrip,

Malcolm Weller,

Sheikh Dukuly

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 28, 2023

Abstract Background The burden of the COVID-19 pandemic in terms morbidity and mortality differentially affected populations. Between within populations, behaviour change was likewise heterogeneous. Factors influencing precautionary adoption during have been associated with multi-dimensional aspects risk perception; however, influence lived experiences other recent outbreaks on has less studied. Methods To consider how direct disease experience (‘near misses’) 2014–2016 Ebola virus (EVD) outbreak may impacted early waves West Africa, we analyzed data from a mixed-methods study that included phone-based survey in-depth interviews among vaccinated Liberian adults. Logistic regression via generalized estimating equations QIC-based model selection conducted to evaluate interaction between individual effects (EVD COVID-19) ‘near miss’ behaviours. Thematic analysis interview transcripts explored reasons for differential two outbreaks. Results At population level, being not significantly different behavior versus Ebola; overall, people had lower odds adopting behaviors relative Ebola. Qualitatively, participants often reflected themes around more proximal personal than COVID-19; they also commented EVD led better preparedness at systems level communities behave an outbreak, despite such awareness necessarily translating into action COVID-19. Conclusion results suggest perceived proximity intensity threats space time affects behavioural decisions. For successive threats, comparisons present past compound those effects, regardless whether individuals directly experience. Measures, as communication community engagement efforts, gauge reflect previous should be considered response strategies enhance adoption.

Language: Английский

Decongesting Global Cities as Part of Health Reform in the Era of COVID-19: Impacts and Implications for Zimbabwe DOI
Isaac Nyambiya, Lawrence Sawunyama

Global perspectives on health geography, Journal Year: 2023, Volume and Issue: unknown, P. 189 - 208

Published: Jan. 1, 2023

Language: Английский

Citations

0
Diagnostic performance of LumiraDx SARS-CoV-2 rapid antigen test compared to PCR for diagnosis of COVID-19 in Liberia DOI Open Access

Moses Badio,

Christina Lindan, Kumblytee Johnson

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 6, 2023

Abstract Background Diagnosis of SARS-CoV-2 infection in Liberia has primarily relied on polymerase chain reaction (PCR)-based testing at the country’s National Reference Laboratory. This centralized approach caused reporting delays, prompting evaluation point-of-care antigen-based tests. We assessed test performance LumiraDx™ Ag (LumiraDx™, London, UK) this setting. Methods tested ambulatory individuals screened for enrollment into an observational cohort study COVID-19 sequelae Monrovia 2021. compared results LumiraDx anterior nasal swab specimens to PCR BioFire® R2.1P (bioMérieux, Salt Lake City, Utah) eluent from nasopharyngeal swabs. Results evaluated 348 individuals. Among 274 persons with symptoms, 49.3% were PCR-positive and 36.5% antigen-positive. The sensitivity, specificity, negative predictive value (NPV), positive (PPV) group 72.6% (95% CI: 64.3%-79.9%), 98.6% 94.9%-99.8%), 78.7% (CI: 71.9%-84.6%), 98.0% 93.0%-99.8%), respectively. 74 asymptomatic individuals, 12.2% by PCR, 5.5% antigen testing, resulting a NPV, PPV 44.4% 13.7%-78.8%), 100% 94.5%-100%), 92.9% 84.1%-97.6%), 39.8%-100%), Conclusion Although specificity diagnosing high among without sensitivity was unacceptably low both groups, much less than that reported manufacturer. Before new diagnostics are adopted, needs be local

Language: Английский

Citations

0
Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study DOI Creative Commons
John Kimotho, Yiakon Sein, Shahin Sayed

et al.

Wellcome Open Research, Journal Year: 2023, Volume and Issue: 8, P. 350 - 350

Published: Aug. 17, 2023

Background: Given the low levels of coronavirus disease 2019 (COVID-19) vaccine coverage in sub-Saharan Africa (sSA), despite high natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exposures, strategies for extending breadth and longevity naturally acquired immunity are warranted. Designing such will require a good understanding immunity. Methods: We measured whole-spike immunoglobulin G (IgG) spike-receptor binding domain (RBD) total immunoglobulins (Igs) on 585 plasma samples collected longitudinally over five successive time points within six months COVID-19 diagnosis 309 patients. We antibody-neutralising potency against wild-type (Wuhan) SARS-CoV-2 pseudovirus subset 51 patients three points. Binding neutralising antibody potencies were then tested correlations with severities. Results: Rates seroconversion increased from day 0 (day PCR testing) to 180 (six months) (63.6% 100 %) (69.3 % 97%) anti-spike-IgG anti-spike-RBD Igs, respectively. Levels these antibodies peaked at 28 (p<0.0001) subsequently maintained without significant decay (p>0.99). Similarly, but declined by three-fold, after (p<0.0001). highly correlated neutralising antibody all analysed (r>0.6, p<0.0001). severity. Conclusions: Most generated specific that remained stable first infection. However, respective decayed three-fold month-six suggesting they short-lived, consistent what has been observed elsewhere world. Thus, regular vaccination boosters required sustain anti-SARS-CoV-2 our population.

Language: Английский

Citations

0
Cellular Immune Response to SARS-CoV-2 Suggests a Possible Link to Endemic Malaria DOI
Kesego Tapela, Diana Ahu Prah,

Becky Tetteh

et al.

Published: Jan. 1, 2023

Ghana and other parts of West Africa have experienced significantly lower mortality rates from COVID-19 in comparison to regions. This phenomenon has been attributed previous exposure infections such as malaria. study was conducted investigate the SARS-CoV-2 immune response impact malaria Ghana. Blood samples were collected (n=217) individuals who had classified either asymptomatic or symptomatic. Serology assays utilized evaluate phenotype, specific responses, while P. falciparum-specific antibodies quantified using ELISA. The found evidence attenuated responses among individuals, with elevated proportions non-classical monocytes greater memory B-cell activation. Symptomatic patients displayed higher T-cell recall demonstrated falciparum antibody levels. concludes that exposure-associated modulation may contribute reduced severity people living malaria-endemic

Language: Английский

Citations

0
Unraveling the effects of the Ebola experience on behaviour choices during COVID-19 in Liberia: A mixed methods study across successive outbreaks DOI Creative Commons
Laura Skrip,

Malcolm Weller,

Sheikh Dukuly

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 28, 2023

Abstract Background The burden of the COVID-19 pandemic in terms morbidity and mortality differentially affected populations. Between within populations, behaviour change was likewise heterogeneous. Factors influencing precautionary adoption during have been associated with multi-dimensional aspects risk perception; however, influence lived experiences other recent outbreaks on has less studied. Methods To consider how direct disease experience (‘near misses’) 2014–2016 Ebola virus (EVD) outbreak may impacted early waves West Africa, we analyzed data from a mixed-methods study that included phone-based survey in-depth interviews among vaccinated Liberian adults. Logistic regression via generalized estimating equations QIC-based model selection conducted to evaluate interaction between individual effects (EVD COVID-19) ‘near miss’ behaviours. Thematic analysis interview transcripts explored reasons for differential two outbreaks. Results At population level, being not significantly different behavior versus Ebola; overall, people had lower odds adopting behaviors relative Ebola. Qualitatively, participants often reflected themes around more proximal personal than COVID-19; they also commented EVD led better preparedness at systems level communities behave an outbreak, despite such awareness necessarily translating into action COVID-19. Conclusion results suggest perceived proximity intensity threats space time affects behavioural decisions. For successive threats, comparisons present past compound those effects, regardless whether individuals directly experience. Measures, as communication community engagement efforts, gauge reflect previous should be considered response strategies enhance adoption.

Language: Английский

Citations

0