Association of neutrophil-to-lymphocyte ratio with all-cause and cardiovascular mortality in CVD patients with diabetes or pre-diabetes

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 17, 2024

The neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammation, is crucial in the progression cardiovascular diseases (CVD). Its predictive value for all-cause and mortality CVD patients with diabetes or pre-diabetes remains unclear. We analyzed 3,780 from National Health Nutrition Examination Survey (2001-2018). Kaplan-Meier survival curves, weighted Cox proportional hazards models, restricted cubic spline (RCS) analyses were used to assess relationship between NLR risk. RCS revealed U-shaped association mortality, an inflection point at 1.776. For < 1.776, risk decreased by 13% per unit increase (HR: 0.87, 95% CI: 0.76-0.98). ≥ increased 15% 1.15, 1.10-1.26). A positive linear was found 17% 1.17, 1.10-1.25). No significant interactions observed stratified analyses. Our study pre-diabetes.

Language: Английский

Prognostic effect of neutrophil percentage-to-albumin ratio (NPAR) on all-cause and cardiovascular mortality in diabetic kidney disease (DKD): NHANES 1999–2018

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 28, 2025

This study aimed to evaluate the associations between neutrophil percentage-to-albumin ratio (NPAR) and both all-cause cardiovascular mortality in diabetic kidney disease (DKD) patients. The data for this were sourced from National Health Nutrition Examination Survey (NHANES) 1999–2018. Weighted logistic regression, Cox proportional hazards model, Fine-Gray competing risk model used assess association NPAR DKD A total of 2,699 participants enrolled study. regression analysis revealed that elevated levels associated with a higher all (HR: 2.17, 95%CI: 1.83–2.58). Meanwhile, significant difference was observed males 1.83, 1.42–2.38) but not females. Finally, adjusted identified as an independent predictor (SHR: 1.86 1.28–2.72) In nationally representative sample US, detected increased mortality. addition, gender differences relationship also observed.

Language: Английский

Dynamic changes of inflammatory markers in the early stages of chronic kidney disease in patients with type 1 diabetes mellitus

Bulletin of Russian State Medical University, Journal Year: 2024, Volume and Issue: 2024(6)

Published: Dec. 1, 2024

Diabetes mellitus (DM) is one of the major factors contributing to development and aggravation chronic kidney disease (CKD). The accurate convenient markers for early detection, estimation progression, adequate control CKD therapy in individuals with DM are limited glomerular filtration rate (GFR) albuminuria. Given role inflammation pathogenesis CKD, study aimed assess indicators correlation those GFR patients type 1 (T1D) stage CKD. involved healthy (n = 14), T1D showing no signs 30), as well 60), 2 38), 3 31). was calculated using formula СКD-ЕРI (eGFR); serum levels IL1β TNFα, C-reactive protein (CRP), ceruloplasmin (CP) were determined by enzyme immunoassay; neutrophil-to-lymphocyte index leukocyte intoxication (LII) calculated. It has been found that concentrations IL1β, CRP, CP elevated; LII increased. acute phase response severity progresses reaches its maximum 3b when concentration increased 2.4-fold (р 0.042), TNFα 34% 0.005), CRP 33-fold < 0.000), 73% 0.008), 8.4-fold 5-fold 0.013). integral function indicator, eGFR, decreases increasing above indicators. Thus, CP, LII, can be considered affordable informative inflammation, which increase progression T1D.

Language: Английский