Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 11, 2025

Language: Английский

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Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2061 - 2061

Published: March 18, 2025

Background/Objectives: Regenerative therapies have gained interest in orthopedic applications for their potential to enhance tissue regeneration, functional recovery, and pain modification. This review evaluates the clinical efficacy of platelet-rich plasma (PRP), mesenchymal stem cells (MSCs), peptide-based treatments, biomimetic materials care, with a focus on reduction outcomes. Methods: A structured literature search PubMed (January 2009–January 2025) identified 160 studies. After applying inclusion criteria prioritizing randomized controlled trials (RCTs) trials, 59 studies were included: 20 PRP, MSCs, 10 peptide therapies, 7 biomimetics. Data extraction focused risk bias assessed using Cochrane Risk Bias (RoB) tool ROBINS-I tool. random-effects meta-regression analysis was conducted evaluate impact therapy type, sample size, reported Results: Meta-regression MSC as most effective intervention (β = 8.45, p < 0.05), PRP showing moderate improvements, demonstrating lowest effect. provided short-term relief, particularly acute injuries tendon repair, though inconsistencies preparation methods limited success chronic conditions. demonstrated cartilage regeneration early osteoarthritis improvement, but high costs ethical concerns remain barriers widespread adoption. Peptide-based materials, including engineered scaffolds autologous protein solutions, showed promise infection control wound healing, further research is needed optimize dosing, delivery methods, long-term safety. Conclusions: offer significant reliable regenerative effects, providing symptomatic treatments emerging promising adjuncts. However, standardized protocols large-scale are establish improve translation broader

Language: Английский

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The Effects of Ongoing Physical Activity on the Lumbar Spine in Mature Athletes

Balneo and PRM Research Journal, Journal Year: 2025, Volume and Issue: 16(Vol 16 No. 1), P. 784 - 784

Published: March 31, 2025

This research looks into how common and impactful degenerative lumbar disc disease (DLDD) is among older athletes. It specifically examines being active affects the progression of this condition its accompanying symptoms. By using a mix clinical data, imaging tests, health surveys, study focused on varied group athletes aged 40 older. The main findings show clear link between level athletic activity severity DLDD, with differences seen across various sports. Endurance were found to have more cases symptomatic degeneration than those who focus strength. These results highlight need understand specific risks that face, improving knowledge about causes development DLDD in group. are important as they could guide practices prevention strategies, helping healthcare providers manage ways suit better. Overall, promotes team-based approach tackles both performance spinal for population, encouraging healthier aging continued involvement.

Language: Английский

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Geographical variation in high-impact chronic pain and psychological associations at the regional level: a multilevel analysis of a large-scale internet-based cross-sectional survey

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 12, 2024

Background A geographical analysis could be employed to uncover social risk factors and interventions linked chronic pain. Nonetheless, variation in pain across different regions of Japan have not been well explored. This study aims investigate high-impact (HICP), defined as moderate severe pain, examine the associated psychological at prefecture level. Methods cross-sectional Internet-based survey involving 52,353 participants was conducted assess conditions, stress levels, mood states, educational living status, regions, sleep duration, exercise habits. evaluated prevalence HICP level, a multilevel explored for both individual levels. Results The revealed that Fukushima exhibited highest (23.2%; z -score = 2.11), Oita ranked second (23.0%; 2.00), Okinawa showed lowest (14.9%; −2.45). Geographical maps indicated regional-level subjective stress, negative emotions, short were with higher prevalence. In contrast, positive such vigor, lower Multilevel significant improvement model fit after incorporating level ( p &lt; 0.001) identified associations between high low vigor 0.001). Conclusion There are regional differences prevalence, HICP.

Language: Английский

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Injection of Amniotic Membrane and Umbilical Cord Particulate for Muscle and Ligament Tears in Collegiate Football Athletes: A Single-Center, Retrospective Study

Orthopedic Research and Reviews, Journal Year: 2024, Volume and Issue: Volume 16, P. 295 - 301

Published: Nov. 1, 2024

Football is a leading cause of sports-related injuries, accounting for more than half time-loss injuries in men's collegiate sports. Amniotic membrane and umbilical cord (AM/UC) powder injection novel treatment that may aid functional recovery return to play athletes due its anti-inflammatory, anti-scarring, pro-regenerative properties.

Language: Английский

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