Quantitative Real-Time RT-PCR Verifying Gene Expression Profile of Cavitations Within Human Jaw Bone DOI Creative Commons
Shahram Ghanaati, Eva Dohle, Fabian Schick

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1144 - 1144

Published: May 8, 2025

Background/Objectives: Immune cells are integral to bone homeostasis, including the repair and remodeling of tissue. Chronic dysregulation within this osteoimmune network can lead marrow defects jaw (BMDJ), particularly fatty degenerative osteonecrosis (FDOJ). These localized pathologies implicated in systemic immune dysfunctions. Methods: This study is designed determine whether BMDJ/FDOJ samples indicative medullary pathology by evaluating FDOJ gene expression patterns using quantitative real-time PCR. Results: Comparative analyses between pathological healthy evaluated key molecular pathways. showed significant upregulation inflammatory mediators, CCL5/RANTES, VEGF, IGF KOR, downregulation structural proteins, such as collagen types I, II IV, osteogenesis-associated factors, SP7. Conclusions: The provides new insights into mechanisms identifying potential changes suggesting a pro-inflammatory state affected jawbone which may contribute dysregulation. findings consistent with morphologic observations degenerated underscore need for integrative approaches dentistry medicine while highlighting target therapeutic preventive strategies against diseases emphasizing its clinical significance.

Language: Английский

Quantitative Real-Time RT-PCR Verifying Gene Expression Profile of Cavitations Within Human Jaw Bone DOI Creative Commons
Shahram Ghanaati, Eva Dohle, Fabian Schick

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1144 - 1144

Published: May 8, 2025

Background/Objectives: Immune cells are integral to bone homeostasis, including the repair and remodeling of tissue. Chronic dysregulation within this osteoimmune network can lead marrow defects jaw (BMDJ), particularly fatty degenerative osteonecrosis (FDOJ). These localized pathologies implicated in systemic immune dysfunctions. Methods: This study is designed determine whether BMDJ/FDOJ samples indicative medullary pathology by evaluating FDOJ gene expression patterns using quantitative real-time PCR. Results: Comparative analyses between pathological healthy evaluated key molecular pathways. showed significant upregulation inflammatory mediators, CCL5/RANTES, VEGF, IGF KOR, downregulation structural proteins, such as collagen types I, II IV, osteogenesis-associated factors, SP7. Conclusions: The provides new insights into mechanisms identifying potential changes suggesting a pro-inflammatory state affected jawbone which may contribute dysregulation. findings consistent with morphologic observations degenerated underscore need for integrative approaches dentistry medicine while highlighting target therapeutic preventive strategies against diseases emphasizing its clinical significance.

Language: Английский

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