Ascorbic Acid and Esketamine for Mental Disorders in Women with Miscarriage: A Randomized Controlled Double-Blind Trial Protocol DOI Creative Commons
Z. J. Ke,

Ying Zhang,

B. Cai

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2025, Volume and Issue: Volume 21, P. 815 - 825

Published: April 1, 2025

Pregnancy leads to vulnerabilities and susceptibilities mental disorders. Miscarriage, as an adverse pregnancy outcome, following curettage for treatment, add the risks of further psychiatric disorders, including depression, anxiety, insomnia, etc., current approaches prevention are unsatisfactory. Ketamine its S-enantiomer esketamine can prevent postpartum even treats depressive symptoms after miscarriage curettage, but their side effects bring limitations. Ascorbic acid (AA, Vitamin C) modulate mood enhance ketamine's antidepressant efficacy synergistically, reducing dosages potentially. The purpose this study is clarify beneficial modification AA on preventing depression other disorders in patients with painless well interaction between esketamine. This a 2×2 factorial, double-blinded, randomized, controlled trial that will recruit women undergoing curettage. A total 424 participants be recruited randomly 1:1:1:1 allocated four groups (106 each): Group A0K0 (normal saline normal saline), A0K1 esketamine), A1K0 (AA A1K1 esketamine). primary outcome incidence postoperative day 7, assessed Edinburgh Postnatal Depression Scale (EPDS). secondary outcomes include EPDS score, assessments sleep, pain, events, perianesthetic data patient satisfaction. provides clinical trial-based evidence alone or combination/interacting emerging rapid-acting Our expected suggest AA's potential application optimizing strategies promoting post-miscarriage health, possible adjunctive improvement (es)ketamine's usage antidepressants. One major limitation single-center study, results might biased due regional factors.

Language: Английский

Esketamine reduces the risk of postpartum depression in women undergoing cesarean section: a systematic review and meta-analysis DOI Creative Commons

Lőrinc Frivaldszky,

Kincső Lőrincz,

Jakub Hoferica

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 183, P. 164 - 173

Published: Feb. 14, 2025

Language: Английский

Citations

1
Ascorbic Acid and Esketamine for Mental Disorders in Women with Miscarriage: A Randomized Controlled Double-Blind Trial Protocol DOI Creative Commons
Z. J. Ke,

Ying Zhang,

B. Cai

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2025, Volume and Issue: Volume 21, P. 815 - 825

Published: April 1, 2025

Pregnancy leads to vulnerabilities and susceptibilities mental disorders. Miscarriage, as an adverse pregnancy outcome, following curettage for treatment, add the risks of further psychiatric disorders, including depression, anxiety, insomnia, etc., current approaches prevention are unsatisfactory. Ketamine its S-enantiomer esketamine can prevent postpartum even treats depressive symptoms after miscarriage curettage, but their side effects bring limitations. Ascorbic acid (AA, Vitamin C) modulate mood enhance ketamine's antidepressant efficacy synergistically, reducing dosages potentially. The purpose this study is clarify beneficial modification AA on preventing depression other disorders in patients with painless well interaction between esketamine. This a 2×2 factorial, double-blinded, randomized, controlled trial that will recruit women undergoing curettage. A total 424 participants be recruited randomly 1:1:1:1 allocated four groups (106 each): Group A0K0 (normal saline normal saline), A0K1 esketamine), A1K0 (AA A1K1 esketamine). primary outcome incidence postoperative day 7, assessed Edinburgh Postnatal Depression Scale (EPDS). secondary outcomes include EPDS score, assessments sleep, pain, events, perianesthetic data patient satisfaction. provides clinical trial-based evidence alone or combination/interacting emerging rapid-acting Our expected suggest AA's potential application optimizing strategies promoting post-miscarriage health, possible adjunctive improvement (es)ketamine's usage antidepressants. One major limitation single-center study, results might biased due regional factors.

Language: Английский

Citations

0