Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

Abstract Objective Mixed lineage kinase domain‐like protein (MLKL) is a key component of necroptosis. Here, serum MLKL levels were measured with the intent to assess its prognostic significance in acute intracerebral hemorrhage (ICH). Methods A collective 161 patients primary supratentorial ICH and 73 controls enlisted this multicenter prospective cohort study. Serum at admission all patients, study entry controls, on post‐ICH days 1, 3, 5, 7, 10, 15 patients. Multivariate analyses adopted relationships between levels, severity, early neurological deterioration (END), poststroke 6‐month modified Rankin Scale (mRS) scores, poor prognosis (mRS scores 3–6). Results Patients, relative had significantly promoted from until Day 15, peaking value 3 ( p < 0.001). Admission independently correlated National Institutes Health Stroke (NIHSS) (beta, 0.133; 95% confidence interval (CI), 0.088–0.178; = 0.011), hematoma volume 0.051; 95%CI, 0.037–0.064; 0.001), mRS 0.707; 0.487–0.927; 0.023), as well predicted END (odds ratio, 1.902; 1.229–2.945; 0.014) 2.286; 1.324–3.946; 0.038). linearly connected risks > 0.05) 0.05), no interactions age, gender, hypertension, so forth (all possessed similar areas under receiver operating characteristic curve NIHSS 0.05). The models integrating graphically represented by nomogram good consistency calibration curve. Conclusions are markedly increased shortly following ICH, may accurately mirror disease efficaciously anticipate six‐month bad strengthening biomarker prospect ICH.

Language: Английский