The efficacy of vortioxetine in the acute treatment of major depressive disorder: A systematic review and meta-analysis

Journal of Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Background: Among the available pharmacological treatments for acute major depressive disorder (MDD), vortioxetine, a serotonin transporter inhibitor (SERT), has been widely used its multimodal action on neurotransmission, which produces essential changes also glutamate, gamma amino butyric acid (GABA), norepinephrine, acetylcholine, and dopamine. Aim: This systematic review meta-analysis aimed to evaluate efficacy of vortioxetine across multiple dosing whether there is dose–response effect as well issue with respect side effects in depression. Methods: According PRISMA guidelines, we systematically searched three electronic databases (PubMed/MEDLINE, PsycINFO, Cochrane Central Register Controlled Trials) Randomized Trial (RCT) studies published between January 2013 April 2024. Twenty-four were included two meta-analyses conducted determine mean Montgomery–Asberg Depression Rating Scale (MADRS) scale values placebo groups differ significantly from MADRS group receiving 10 mg or 20 mg. Results: Vortioxetine improved depression severity, anxiety symptoms, cognitive function, high response remission rates MDD. It was tolerated relatively low occurrence severe serious treatment-emergent adverse events (TEAEs). Observing results meta-analysis, significant both mg, greater size Conclusion: should be considered efficacious first- second-line therapy.

Language: Английский

Anhedonia as a Core Symptom of Depression and a Construct for Biological Research

FOCUS The Journal of Lifelong Learning in Psychiatry, Journal Year: 2025, Volume and Issue: 23(2), P. 163 - 172

Published: April 1, 2025

Anhedonia is a key psychiatric symptom that has seen significant advances in its understanding both clinical practice and research over the past few decades. Once considered primarily feature of depression, recent studies have shown anhedonia also core element other disorders contributes to considerable morbidity, mortality, suicidality. Emerging models psychopathology illness emphasize transdiagnostic relevance anhedonia. At same time, neuroimaging provided deeper insights into underlying pathophysiology, several assessment scales with strong psychometric properties been developed. Various treatment strategies-including psychopharmacology, neuromodulation, psychotherapy-have demonstrated varying degrees effectiveness. This review discusses evolving anhedonia, significance as diagnostic marker, prevalence, pathophysiological underpinnings. Additionally, authors provide an overview tools explore range approaches studied date.

Language: Английский