Molecular Therapy — Oncolytics, Journal Year: 2022, Volume and Issue: 25, P. 98 - 120

Published: March 16, 2022

The tumor microenvironment (TME) is a well-recognized system that plays an essential role in initiation, development, and progression. Intense intercellular communication between cells other (especially macrophages) occurs the TME mediated by cell-to-cell contact and/or soluble messengers. Emerging evidence indicates noncoding RNAs (ncRNAs) are critical regulators of relationship within TME. In this review, we provide update on regulation ncRNAs (primarily micro [miRNAs], long [lncRNAs], circular [circRNAs]) crosstalk macrophages hepatocellular carcinoma (HCC). These derived from or act as oncogenes suppressors, contributing to progression not only regulating physiological pathological processes but also controlling macrophage infiltration, activation, polarization, function. Herein, explore options available for clinical therapeutic strategies targeting crosstalk-related treat HCC. A better understanding will uncover new diagnostic biomarkers pharmacological targets cancer. 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