Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive system with high incidence that seriously threatens patients' lives and health. However, rise application new treatments, such as immunotherapy, there are still some restrictions in treatment diagnosis HCC, therapeutic effects on patients not ideal. Two single-cell RNA sequencing (scRNA-seq) datasets from HCC patients, encompassing 25,189 cells, were analyzed study. We utilized non-negative matrix factorization (NMF) clustering to identify mitophagy patterns TME including cancer-associated fibroblasts (CAFs), T B tumor-associated macrophages (TAMs). Cell-to-cell communication was using CellChat package, pseudotime trajectory analysis performed Monocle package. Gene regulatory networks investigated SCENIC survival analyses conducted mitophagy-related signatures. samples identified 22 clusters, 7 principal cell types. Complex communications observed among these Mitophagy-related CAFs, TAMs, CD8+ cells identified. These subtypes had different biological states, cell-cell communications, metabolic pathways. Mitophagy levels elevated samples. Changes genes within specific associated overall rates. did seem affect effectiveness immunotherapy. This study provides evidence modulates intercellular communication, influencing progression patient prognosis. Targeting may offer promising approach improve long-term prognosis patients.

Language: Английский

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The Role of the Dysregulation of circRNAs Expression in Glioblastoma Multiforme

Journal of Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 75(1)

Published: Jan. 22, 2025

Language: Английский

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Effects of circulating RNAs on tumor metabolism in lung cancer (Review)

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 11

Published: Feb. 27, 2025

During the development and progression of lung cancer, cell metabolism function is altered. Thus, cells rely on aerobic glycolysis abnormal lipid amino acid to obtain energy nutrients for growth, proliferation drug resistance. Circular RNAs (circRNAs), a class non-coding RNAs, serve important biological roles in growth tumors. Functionally, circRNAs act as molecular sponges that absorb microRNAs (miRNAs) RNA-binding proteins protein scaffolds regulate gene transcription translation through maintenance mRNA stability. In addition, are regulators tumor promote mediating proliferation, metastasis induction chemoresistance. Results previous studies reveal may key role regulating metabolic processes miRNA sponging alternative mechanisms. demonstrate potential therapeutic targets cancer. The present study aimed review effects cancer provide novel insights into clinical treatment also theoretical basis targets.

Language: Английский

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CircRNAs in the Tumor Microenvironment: New Frontiers in Cancer Progression and Therapy

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 212, P. 104754 - 104754

Published: May 2, 2025

Language: Английский

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