A Qualitative Study on Perspectives of Parkinson’s Disease Medications: Insights from Patient Focus Groups

Patient Preference and Adherence, Journal Year: 2024, Volume and Issue: Volume 18, P. 1919 - 1928

Published: Sept. 1, 2024

Medication is an important component of the management Parkinson's disease (PD), yet few studies investigate factors that inform medication decision-making from perspective those who use these therapies. This qualitative study aimed to better understand experiences and perspectives people with PD (PwPD).

Language: Английский

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Perceptions on circumcision for HIV prevention: an application of the health belief model in a qualitative enquiry among young men in Eswatini

AIDS Care, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Dec. 29, 2024

Voluntary medical male circumcision (VMMC) was identified as an effective strategy in HIV prevention. Although reduces heterosexual acquisition of by 60%, there is low uptake VMMC services Eswatini. This study applies the health belief model (HBM) understanding perceptions young men Eswatini towards for prevention to upscale its adoption. A qualitative design followed. Uncircumcised males aged 20–29 years were recruited among university students. In-depth interviews conducted, transcribed verbatim, and transcripts imported into NVivo12 line-by-line analysis. Emerging codes categorized under major constructs HBM. Condomless sex, having multiple sex partners, genital caressing being uncircumcised seen susceptible exposure. Taking life-long treatment stigma perceived severity. However, participants had no intent circumcise near future even after acknowledging Hygiene, sexually transmitted infections including main benefits. Fear pain key barrier impeding adopting seemed outweigh benefits some participants. These findings will assist programme planners review promote that improve good well-being avert new

Language: Английский

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Dual Trajectories of Antiretroviral Therapy Adherence and Polypharmacy in Women with HIV in the United States

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 23, 2023

Abstract Background Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed identify interrelationship between trajectories adherence antiretroviral therapy (ART) and polypharmacy. Methods included women with HIV (aged ≥ 18) enrolled in Women's Interagency Study United States from 2014 2019. used group-based trajectory modeling (GBTM) ART polypharmacy dual GBTM Results Overall, 1,538 were eligible (median age 49 years). analysis revealed latent 42% grouped consistently moderate trajectory. identified four 45% categorized low group. Conclusions The joint model did not reveal any trajectories. Future research should consider examining both variables objective measures adherence.

Language: Английский

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Reasons for antiretroviral switching in Colombia: A retrospective cohort study

International Journal of STD & AIDS, Journal Year: 2023, Volume and Issue: 34(13), P. 921 - 931

Published: July 10, 2023

Long-term use of antiretroviral therapy (ART) for HIV infection might lead to the necessity switching regimens. We aimed analyze reasons ART switch, time-to-switch ART, and its associated factors in a Colombian cohort.We conducted retrospective cohort 20 clinics, including participants ≥18 years old with confirmed who underwent an switch from January 2017 December 2019 at least 6 months follow-up. A time-to-event analysis exploratory Cox model were performed.796 switched during study period. The leading cause was drug intolerance (n = 449; 56.4%) median 12.2 months. longest due regimen simplification (42.4 months). People ≥50 (HR 0.6; 95% CI (0.5-0.7) CDC stage 3 diagnosis 0.8; (0.6-0.9) had less hazard over time.In this cohort, main is shorter than reports other countries. In Colombia, it crucial apply current recommendations initiation choose regimens better tolerability profile.

Language: Английский

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Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 3, 2022

This paper is based on a retrospective longitudinal study people living with HIV under antiretroviral treatment (ART) where allelic variants (either heterozygous CT genotype or homozygous CC genotype) have been evaluated at position -168 of the promoter region protein kinase R (-168/PKR). In general, antiviral effects interferon are partially mediated by RNA-dependent (PKR) that, once activated, inhibits synthesis. Indeed, activation PKR response can inhibit replication. To explore role in shaping dynamics commonly monitored biomarkers, CD4 cells, CD8 cells and HIV-load were modelled within latent class mixed model (LCMM) to account for participants' heterogeneity over time. The estimated models identified two sub-groups from dynamics, revealing better outcomes subgroups participants genotype. Heterozygous subjects one exhibited higher increase more marked decrease HIV-load, time, respect assigned same group.

Language: Английский

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HIV ile Yaşayan Bireylerde İmmunolojik ve İnflamatuar Belirteçler ile Karotis Arter İntima-Media Kalınlığı Arasındaki İlişkinin Araştırılması

Dicle Medical Journal / Dicle Tip Dergisi, Journal Year: 2022, Volume and Issue: 49(4), P. 717 - 724

Published: Dec. 18, 2022

Amaç: Bu çalışmada HIV ile yaşayan bireylerde (HİYB) immünolojik belirteçler olan CD4, CD8, CD4/CD8; inflamatuar parametrelerden C-reaktif protein (CRP), Eritrosit sedimentasyon hızı (ESH), prokalsitonin, D-dimer; hemogram sonuçlarından elde edilen nötrofil/lenfosit oranı (NLR), platelet/lenfosit (PLR) ve CRP/lenfosit (CLR) değerleri karotis arter intima-media kalınlığı (CIMT) arasında ilişki olup olmadığının belirlenmesi amaçlanmıştır. Yöntemler: kesitsel, tek merkezli çalışmaya Haziran 2020- Kasım 2021 tarihleri merkezimizde takipli, 18-40 yaş aralığında ek hastalığı (obezite, kardiyovasküler hastalık, diyabetes mellitus, hipertansiyon) olmayan, antiretroviral tedavi (ART) alan, HIV-RNA’sı negatif (viral suprese) 49 HİYB dahil edildi. Hastaların demografik, antropometrik laboratuvar verileri kaydedildi. Her hastanın CIMT ölçümü B-mode Ultrasonografi yapıldı. Subklinik ateroskleroz için cut-off değeri 0.9 mm kabul edildi. Bulgular: Olguların medyan ART kullanım süresi 19 (8-43) ay, CD4 sayısı 605 (438-913) hücre/μL, sağ ölçüm 0.48 (0.42-0.58) sol 0.46 (0.41-0.58) olarak saptandı. Hiçbir hastada plak formasyonu gözlenmedi. Medyan pozitif düşük orta düzeyde (rho=0.341, p=0.016), ise bir korelasyon saptandı (rho=0.517, p

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