Neurocognitive Features of Mild Cognitive Impairment and Distress Symptoms in Older Adults Without Major Depression.

PubMed, Journal Year: 2024, Volume and Issue: 19, P. 1445 - 1459

Published: Jan. 1, 2024

Two distinct symptom dimensions were identified in older adults who did not have major depressive disorder (MDD): a) a dimension associated with mild cognitive dysfunction, and b) related to distress symptoms of old age (DSOA). It is uncertain whether previous findings regarding the features amnestic impairment (aMCI) remain valid when patients MDD are excluded.

Language: Английский

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Is amnestic mild cognitive impairment a neuro-immune condition?

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 6, 2024

Abstract Background The pathophysiology of amnestic Mild Cognitive Impairment (aMCI) is largely unknown, although some papers found signs immune activation. Aims To assess the cytokine network in aMCI after excluding patients with major depression (MDD) and to examine profiles quantitative (qMCI) distress symptoms old age (DSOA) scores. Methods A cross-sectional study was conducted on 61 Thai participants 60 healthy adults (both without MDD). Bio-Plex Pro human 27-plex test kit LUMINEX 200 were used assay cytokines/chemokines/growth factors fasting plasma samples. Results characterized by significant general immnosuppression, reductions T helper 1 (Th)1 cell growth profiles, immune-inflammatory responses system, interleukin (IL)1β, IL6, IL7, IL12p70, IL13, GM-CSF, MCP-1 as compared controls. These 7 cytokines/chemokines exhibit neuroprotective effects at physiologic concentrations. In multivariate analyses, three neurotoxic chemokines, CCL11, CCL5, CXCL8, emerged predictors aMCI. Logistic regression showed that best predicted combining IL1β, MCP-1, years education (all inversely associated) CCL5 (positively associated). We 38.2% variance qMCI score explained (inversely DSOA not associated any data. Discussion dysbalance between lowered levels cytokines relative increases chemokines are key Future MCI research should always control for confounding affective symptoms.

Language: Английский

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Disorders in lipid metabolism, oxidative stress, and antioxidants in patients with amnestic mild cognitive impairment without major depression

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 9, 2024

Abstract Background Amnestic mild cognitive impairment (aMCI) is characterized by changes in lipids and oxidative stress (OS). It crucial to exclude patients with major depression (MDD) accurately evaluate these biomarkers aMCI. Aims To examine lipid associated aMCI versus normal controls. Methods We performed a case-control analysis involving 61 individuals (without MDD) 60 healthy assessed the severity of aMCI, distress symptoms old age, lipid/OS biomarkers. Results The levels serum -SH groups were significantly higher while malondialdehyde (MDA) lower same group. Serum advanced oxidation protein products, glutathione, folic acid did not show any notable variations. In we observed an elevated apolipoprotein B (ApoB)/ApoA ratio, as well decreased high-density lipoprotein cholesterol (HDL), ApoA, reverse transport (RCT) index. simultaneous presence subclinical depressive marked triglycerides ApoB, ApoA HDL. A significant portion variability (24.9%) quantitative MCI score can be attributed groups, age (positively), MDA education (inversely). Discussion alterations may potentially disrupt redox signaling, which affect cell signaling homeostatic setpoints. interaction between lead increased atherogenicity reduced antiatherogenic protection.

Language: Английский

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Is Amnestic Mild Cognitive Impairment a Neuro-Immune Condition?

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Objectives The pathophysiology of amnestic Mild Cognitive Impairment (aMCI) is largely unknown, although some papers found signs immune activation. To assess the cytokine network in aMCI after excluding patients with major depression (MDD) and to examine profiles quantitative (qMCI) distress symptoms old age (DSOA) scores. Design: A case-control study. Setting: Department Psychiatry a University Hospital, Bangkok, Thailand. Participants : 61 Thai participants 60 healthy adults (both without MDD). Measurements Bio-Plex Pro human 27-plex test kit was used assay cytokines/chemokines/growth factors fasting plasma samples. Results characterized by significant general immunosuppression, reductions T helper 1 (Th)1 cell growth profiles, immune-inflammatory responses system, interleukin (IL)1β, IL6, IL7, IL12p70, IL13, GM-CSF, MCP-1. These 7 cytokines/chemokines exhibit neuroprotective effects at physiologic concentrations. In multivariate analyses, three neurotoxic chemokines, CCL11, CCL5, CXCL8, emerged as predictors aMCI. Logistic regression showed that best predicted combining IL1β, MCP-1, years education (all inversely associated) CCL5 (positively associated). We 38.2% variance qMCI score explained (inversely DSOA not associated any data. Discussion dysbalance between lowered levels cytokines relative increases chemokines are key Future MCI research should always control for confounding affective symptoms.

Language: Английский

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Cytokine dysregulation in amnestic mild cognitive impairment

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 28, 2024

Language: Английский

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