Optimizing Mesenchymal Stem Cells for Regenerative Medicine: Influence of Diabetes, Obesity, Autoimmune, and Inflammatory Conditions on Therapeutic Efficacy: A Review

Medical Science Monitor, Journal Year: 2024, Volume and Issue: 30

Published: July 23, 2024

Mesenchymal stem cells (MSCs) are a promising tool that may be used in regenerative medicine. Thanks to their ability differentiate and paracrine signaling, they can the treatment of many diseases. Undifferentiated MSCs support regeneration surrounding tissues through secreted substances exosomes. This is possible thanks production growth factors. These factors stimulate neighboring cells, have an anti-apoptotic effect, angiogenesis, also immunomodulatory effect. The level vary depending on Apart from donor's health condition, it influenced by source MSCs, methods harvesting, even banking cells. work review research how patient's condition affects properties obtained MSCs. discusses impact diabetes, obesity, autoimmune diseases, inflammation, as well harvesting phenotype, differentiation capacity, anti-inflammatory, angiogenic effects, proliferation potential Knowledge about specific clinical allows for better use more appropriate targeting procedures collecting, multiplying, these subsequent use. article aims characteristics, banking, signaling role inflammatory

Language: Английский

Generation and clinical applications of stem cells in regenerative medicines

Journal of Applied and Natural Science, Journal Year: 2024, Volume and Issue: 16(4), P. 1417 - 1430

Published: Dec. 20, 2024

Since the discovery of stem cells, they have been claimed to be nature’s miracle due their unique properties, which set them apart from other cell types. It has fascinated world with its myriad opportunities in regenerative medicine, such as treating blood-borne cancers, neurodegenerative diseases and disorders, immune system diseases, heart etc. Although Stem Cell Therapy is yet commercialized India, research clinical trials using Hematopoietic Transplantation are being conducted understand efficacy cells remission various malignant non-malignant Thalassemia, Acute Lymphoblastic Leukemia, Sickle Disease, Aplastic Anemia, Hodgkin’s Lymphoma Juvenile Rheumatoid Arthritis among diseases. bloomed over years demonstrated immense potential Embryonic Therapy, Somatic Induced Pluripotent and, further understanding it could also applied drug modelling development, skin replacement regeneration, organ repair regeneration disease for testing, revolutionizing healthcare industry future. The present review discusses on applications economic, regulatory ethical concerns.

Language: Английский

Evaluation of maternal serum vascular endothelial growth factor C and D levels in intrahepatic cholestasis of pregnancy

International Journal of Gynecology & Obstetrics, Journal Year: 2023, Volume and Issue: 164(3), P. 979 - 984

Published: Sept. 7, 2023

Language: Английский