Physician Assistant Clinics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3521 - 3521
Published: March 20, 2024
The phrase “Let food be thy medicine…” means that can a form of medicine and food; in other words, the diet we eat have significant impact on our health well-being. Today, this is gaining prominence as more scientific evidence suggests one’s help prevent treat disease. A rich fruits, vegetables, whole grains, lean protein reduce risk heart disease, cancer, diabetes, problems and, hand, processed foods, added sugars, saturated fats increase same diseases. Electrophilic compounds health, they are molecules covalently modify cysteine residues present thiol-rich Keap1 protein. These bind to activate NRF2, which promotes its translocation nucleus binding DNA ARE region, triggering antioxidant response protecting against oxidative stress. include polyphenols flavonoids nucleophilic but converted electrophilic quinones by metabolic enzymes such polyphenol oxidases (PPOs) sulfur foods Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) garlic. This review summarizes current knowledge subject.
Language: Английский
Citations
8
Diseases, Journal Year: 2024, Volume and Issue: 12(5), P. 103 - 103
Published: May 14, 2024
Bile acids (BAs) and bilirubin, primarily known for their role in lipid metabolism as heme catabolite, respectively, have been found to diverse effects on various physiological processes, including oxidative stress inflammation. Indeed, accumulating evidence showed that the interplay between BAs bilirubin these processes involves intricate regulatory mechanisms mediated by specific receptors signaling pathways under certain conditions contexts. Oxidative plays a significant development progression of cardiovascular diseases (CVDs) due its inflammation, endothelial dysfunction, hypertension, other risk factors. In (CV) system, recent studies suggested some opposite related inflammatory mechanisms, but this area research is still investigation. This review aims introduce from biochemical point view, emphasizing potential protective or detrimental CVDs. Moreover, clinical assessed association BAs/bilirubin CVD were examined depth better interpret possible link them.
Language: Английский
Citations
7
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: April 4, 2024
Cardiovascular diseases (CVD) represent a major health problem worldwide. In Italy, despite the decline in CVD mortality and disability-adjusted life years recently observed, remains leading cause of death. The development has complex multifactorial etiology that involves environmental, lifestyle/behavioral (e.g., unhealthy diet, physical inactivity, smoking, alcohol abuse), metabolic, genetic factors. Although large number susceptibility variants have been identified, some seem to confer risk according background or ethnicity population. Some CVD-associated polymorphisms with appreciable frequency Italian population may be important contributors progression most prevalent This literature review aims provide an overview epidemiology as well highlight main genetic, lifestyle/behavioral, metabolic factors contributing this
Language: Английский
Citations
6
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3179 - 3179
Published: May 29, 2024
Cardiovascular disease (CVD) is the primary cause of death and disability worldwide. Although age-standardized CVD mortality rates decreased globally by 14.5% between 2006 2016, burden remains disproportionately higher in low- middle-income countries compared to high-income countries. Even though proven, effective approaches based on multiple-drug intake aimed at prevention treatment are currently available, poor adherence, early discontinuation treatment, suboptimal daily execution prescribed therapeutic regimes give rise shortfalls drug exposure, leading high variability responses medications. Wald Law, their landmark paper published BMJ 2003, hypothesized that use a fixed-dose combination statins, β-blockers, angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, aspirin (classic Polypill composition) may increase adherence decrease up 80% when as or substitution traditional protocols. Since then, many clinical trials have tested this hypothesis, with comparable results. This review aims describe available performed assess impact combinations cost-effectiveness, risk factors critical onset CVD.
Language: Английский
Citations
5
Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1134 - 1134
Published: Sept. 9, 2024
Cardiovascular illnesses remain the primary cause of death, accounting for at least 17.9 million fatalities per year and posing a significant public health problem because its extensive predominance effect on healthcare systems. The etiology cardiovascular disease is complex involves several environmental lifestyle factors. Alcohol use highly important determinant dual-edged health. Multiple studies indicate that moderate alcohol consumption may have certain advantages, such as slight enhancements in lipid profiles. Conversely, excessive intake associated with serious negative consequences, including cardiomyopathy, hypertension, arrhythmias, even mortality. aim this study to provide comprehensive analysis effects their understanding within medical field over time. It uses an interpretative narrative review methodology analyzes focus genetic risk factors, gender differences, shifts paradigms recent years. This article highlights need obtaining thorough support guidelines clinical practice, it underscores significance into broader context management identifies subjects further study.
Language: Английский
Citations
5
Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 925 - 925
Published: March 23, 2024
Background: The aim of the present research was to determine factors influencing prevalence eating behaviors, diet quality, and unhealthy among primary healthcare patients in Poland. Methods: cross-sectional study included 896 adult care Łódź. conducted from January 2020 December 2021 thirty-four facilities. A survey recorded sociodemographic data respondents as well regarding their health condition diet. Results: majority (57.6%) had average dietary habits, while 40% habits. univariable logistic regression found that with medium/secondary education a 1.5 times greater risk those post-secondary vocational 1.75 habits than higher (OR = 1.46; 95% CI: 1.08–1.97, p ≤ 0.01, OR 1.75; 1.04–2.94, 0.05). multivariable confirmed level significant impact on habits: for education, 1.40; 1.03–1.91 (p 0.01); 1.69; 1.0–2.85 Conclusions: significantly correlated behaviors studied population. This factor should be considered promotion healthy nutritional counseling interventions by family physicians care.
Language: Английский
Citations
4
Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1082 - 1082
Published: April 7, 2024
Background: Cardiovascular and metabolic diseases include a large group of pathologies constitute one the most serious chronic health problems facing 21st century, with high rates morbidity mortality worldwide. Unhealthy diets influence development these pathologies. The Mediterranean diet can be an important part in treatment diseases. objective this study was to assess effect program that aims increase adherence on improvement different cardiometabolic risk parameters. Methods: A prospective intervention carried out 7034 Spanish workers. Prior intervention, 22 scales were evaluated. Participants informed both orally writing characteristics benefits given website Ministry Health, Consumption Social Welfare Spain, which provides advice nutrition. Adherence reinforced by sending monthly SMS their mobile phones. After six months follow-up, re-evaluated changes. Means standard deviations calculated using Student’s t test analyse quantitative variables. Prevalence Chi-square when variables qualitative. Results: All studied decreased after implementing improve enhance diet. number losses sample very low, standing at 4.31%. Conclusions: is effective reducing all cardiovascular mean values prevalence analysed led lower implementation We observed significant positive difference age sexes. have obtained insulin resistance index, especially SPISE-IR data we not found previous publications. Easy access Internet new information communication technologies facilitate reduce losses.
Language: Английский
Citations
4
Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2047 - 2047
Published: June 27, 2024
Type 2 diabetes mellitus (T2DM) has become a global epidemic. To effectively control T2DM, individuals must adhere to high-quality diet that encompasses not only healthy dietary patterns but also promotes positive eating behaviors. We conducted cross-sectional study on 314 patients with and we evaluated the quality examined associations between behavior, quality, anthropometric clinical factors in T2DM patients. used Diet Quality Index-International Dutch Eating Behavior Questionnaire assess characteristics. found women had significantly higher than men (61.40 vs. 58.68, p = 0.002) were more prone emotional (2.00 1.53, < 0.001) restrained (2.39 2.05, 0.002). Restrained correlated duration of (r −0.169, 0.003), body mass index 0.182, 0.001), external glycated hemoglobin 0.114, 0.044). Patients vitamin C adequacy score (β 0.117, 0.045). External was positively associated grain 0.208, negatively empty-calorie food moderation −0.125, 0.032). For eating, −0.138, 0.017) fruit 0.125, 0.033). In conclusion, results this provide valuable insight into behavior emphasize importance promoting habits for
Language: Английский
Citations
4
Discover Food, Journal Year: 2025, Volume and Issue: 5(1)
Published: Jan. 11, 2025
Hypertension (HT) significantly impacts cardiovascular health (CVH) by exerting chronic stress on arteries and the heart, leading to severe complications. This review explores intricate relationship between dietary choices high blood pressure (BP). Dietary are crucial in both development management of BP. Excessive sodium intake is a well-documented risk factor for HT, strategies reduce salt consumption can mitigate its adverse effects. Processed packaged foods also pose risks due hidden other unhealthy ingredients, making healthier alternatives essential. Potassium plays vital role managing BP, with potassium-rich supporting balanced diet. Saturated trans fats contribute elevated fat recommended. sugar negatively affects sugars popular requiring practical reduction. Alcohol caffeine influence moderate advised avoid potential risks. The Mediterranean diet offers holistic, evidence-based approach enhancing CVH, advice meal plans flavourful health-promoting regimen.
Language: Английский
Citations
0
Life, Journal Year: 2025, Volume and Issue: 15(1), P. 87 - 87
Published: Jan. 13, 2025
Background: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among older adults. Lifestyle modifications, including diet, physical activity, smoking cessation, are key to reducing cardiovascular risk. This study examines the combined effects these behaviors on outcomes their mediating mechanisms. Methods: A cross-sectional was conducted adults (aged ≥ 60 years) in Riyadh, Saudi Arabia. Data dietary quality, status were collected using validated questionnaires. outcomes, low-density lipoprotein cholesterol (LDL), systolic blood pressure (SBP), body mass index (BMI), measured. composite risk score computed. Path analysis employed assess direct indirect lifestyle factors outcomes. Results: Participants adhering healthy engaging regular avoiding had significantly lower scores. Non-smoking showed strongest effect (β = −0.20, p 0.006), while quality activity exhibited significant mediated by LDL, SBP, BMI. Combined adherence multiple resulted greatest reductions The path highlighted as critical mediators health improvements. Conclusions: modifications reduce adults, with cumulative benefits observed for behaviors. These findings emphasize importance comprehensive interventions targeting cessation promote aging populations.
Language: Английский
Citations
0