The effect of targeted therapy on the quality of life of patients with polypous rhinosinusitis and comorbid bronchial asthma DOI Creative Commons
А. M. Korkmazov, M. A. Lengina, M. Yu. Korkmazov

et al.

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 9, P. 38 - 46

Published: June 6, 2024

Introduction . The relevance of studying the possibility using targeted therapy in treatment polypous rhinosinusitis patients with comorbid bronchial asthma is due to observed growth disease and disclosure new pathophysiological mechanisms their development. Aim Based on generalization research results analysis our own clinical observations, improve effectiveness quality life a history severe asthma, genetically engineered biological therapy. Materials methods literature eLibrary databases analyzed.RU RSCI, Medline, Scopus, Web Science for period 2011–2023. inclusion monoclonal antibodies regimen diseases that are difficult treat medication based studies meta-analysis data. A study was conducted, according SF-36 Health Status Survey, 47 receiving medical preventive institutions megalopolis. Results assessment confirmed antibodies. According SP-36 questionnaire, before treatment, low-est scores were Role-Physical Functioning scales – 51.5 points General 49.1 points, respectively. At 2 nd 16 th weeks gradually increasing positive dynamics noted all by end 52 week antibody use, values as close normal possible recorded Social Functioning, Role Emotional, Mental amounted 97.7; 98,3 98.7 points. two cases. Conclusions Knowledge immunological pathogenetic allows us open up significant prospects diagnosis treatment. Recommendations drug selection should be consistently followed within framework recommendations relevant diseases. Strict consideration development short-term long-term risks use necessary.

Language: Английский

Key issues of acute rhinosinusitis DOI Creative Commons
А. А. Кривопалов, I. G. Arustamyan, L. S. Krasheninnikova

et al.

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 7, P. 169 - 176

Published: May 20, 2024

Introduction. There is a clear need to discuss separate issues related acute rhinosinusitis. The rationale that prevalence rates of the disease remain high. At same time, incidence are growing globally, including Russia, Europe, USA and Asia. Apart from that, rhinosinusitis significantly deteriorates patients’ quality life, causing physical, emotional professional malaise. Moreover, complications may have serious consequences, economic costs society significant, both explicit implicit costs. Aim. To raise level awareness otolaryngologists about current based on analysis synthesis literary sources. Mat erials methods. An published literature cause-and-effect relationship between development features in specialized academic research databases RSCI, eLibrary.Ru , Scopus, Web Science, Medline over last ten-year period was carried out. Results discussion. We presented brief overview etiology, epidemiology, risk factors, diagnostic methods results scientific review. treatment prevention strategies, problems antibiotic resistance considered. article brings fore among which it highlights an increasing respiratory viral infections, environmental lifestyle influences. Modern addressed. also emphasized improvement clinical guidelines with focus recent research, stressed importance individual approach each patient, taking into account severity course patients. Conclusions. paper considers conceptual solution for providing medical care patients rhinosinusitis, principles evidence-based medicine regulated by legitimate guidelines, issued before currently force, international ones.

Language: Английский

Citations

0
The effect of targeted therapy on the quality of life of patients with polypous rhinosinusitis and comorbid bronchial asthma DOI Creative Commons
А. M. Korkmazov, M. A. Lengina, M. Yu. Korkmazov

et al.

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 9, P. 38 - 46

Published: June 6, 2024

Introduction . The relevance of studying the possibility using targeted therapy in treatment polypous rhinosinusitis patients with comorbid bronchial asthma is due to observed growth disease and disclosure new pathophysiological mechanisms their development. Aim Based on generalization research results analysis our own clinical observations, improve effectiveness quality life a history severe asthma, genetically engineered biological therapy. Materials methods literature eLibrary databases analyzed.RU RSCI, Medline, Scopus, Web Science for period 2011–2023. inclusion monoclonal antibodies regimen diseases that are difficult treat medication based studies meta-analysis data. A study was conducted, according SF-36 Health Status Survey, 47 receiving medical preventive institutions megalopolis. Results assessment confirmed antibodies. According SP-36 questionnaire, before treatment, low-est scores were Role-Physical Functioning scales – 51.5 points General 49.1 points, respectively. At 2 nd 16 th weeks gradually increasing positive dynamics noted all by end 52 week antibody use, values as close normal possible recorded Social Functioning, Role Emotional, Mental amounted 97.7; 98,3 98.7 points. two cases. Conclusions Knowledge immunological pathogenetic allows us open up significant prospects diagnosis treatment. Recommendations drug selection should be consistently followed within framework recommendations relevant diseases. Strict consideration development short-term long-term risks use necessary.

Language: Английский

Citations

0