(E)-2-Benzylidenecyclanones: Part XX—Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Unexpected Increased Reactivity of 4-Chromanone- Compared to 1-Tetralone Analogs in Thia-Michael Reactions DOI Creative Commons

Gábor Bognár,

Fatemeh Kenari, Zoltán Pintér

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5493 - 5493

Published: Nov. 21, 2024

In vitro relative cytotoxicity (IC

Language: Английский

Degradation of Hydroxychloroquine from Aqueous Solutions Under Fenton-Assisted Electron Beam Treatment DOI Open Access
Stephen Kabasa, Shizong Wang, Yongxia Sun

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(12), P. 2860 - 2860

Published: Dec. 13, 2024

Challenges in the treatment and removal of recalcitrant emerging organic pollutants wastewater prompt development advanced oxidative processes (AOPs). Hydroxyl radicals are non-specific capable reacting with a diverse range concern. In this study, hydroxychloroquine (HCQ) was removed from aqueous solutions efficiencies between 80 90%. The presence H2O2, humic acid, other inorganic ions negatively influenced degradation efficiency. However, S2O82− found to increase efficiency, which attributed formation SO4•− addition •OH radicals. Additionally, Fenton-assisted electron beam showed an improved 2.88 × 10−4 M HCQ average improvement ≈10% at doses 0.5 2.0 kGy total carbon chemical oxygen demand reduction. H2O2 concentration molar ratio H2O2: Fe2+ capacity process. A mechanism for has been proposed based on reactions eaq−.

Language: Английский

Citations

4
Chloroquine degradation under Fenton-assisted electron beam irradiation in aqueous solution DOI
Stephen Kabasa, Yongxia Sun, Shizong Wang

et al.

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis and characterization of polyethyleneimine grafted lignocellulosic fibers for improved removal of nitazoxanide and ampicillin from water DOI
Juliê S. da Costa,

Débora R.S. dos Santos,

Marcela B. Alvarez

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 693, P. 134063 - 134063

Published: April 23, 2024

Language: Английский

Citations

1
(E)-2-Benzylidenecyclanones: Part XX. Reaction of Cyclic Chalcone Analogs with Cellular Thiols. Unexpected Increased Reactivity of 4-Chromanone- Compared to 1-Tetralone-Analogs in Thia-Michael Reactions [1] DOI Open Access

Gábor Bognár,

Fatemeh Kenari, Zoltán Pintér

et al.

Published: July 17, 2024

In vitro cancer cell cytotoxicity (IC50 values) of (E)-3-(4’-methylbenzylidene)-4-chromanone (IIIb) showed >50.0 decreases in comparison to those the respective tetralone derivative (IIIc). On other hand, such a decrease was not observed analogous 4-OCH3 (IIc and IIIc) derivatives. Since compounds can be considered cyclic chalcone analogs, kinetics diastereoselectivity non-enzyme catalyzed reactions with reduced glutathione (GSH) N-acetylcysteine (NAC) IIIb IIIc were investigated assess possible role thiol-reactivity increased IIIb. Reactivity stereochemical outcome evaluated using high-pressure liquid chromatography-mass spectrometry (HPLC-MS). Molecular modeling calculations performed rationalize differences thiol-reactivities chromanones (III) previously tetralones (II). The results indicated spontaneous III their recorded biological effects.

Language: Английский

Citations

1
(E)-2-Benzylidenecyclanones: Part XX—Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Unexpected Increased Reactivity of 4-Chromanone- Compared to 1-Tetralone Analogs in Thia-Michael Reactions DOI Creative Commons

Gábor Bognár,

Fatemeh Kenari, Zoltán Pintér

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5493 - 5493

Published: Nov. 21, 2024

In vitro relative cytotoxicity (IC

Language: Английский

Citations

0