Revolutionizing Drug Delivery: The Impact of Advanced Materials Science and Technology on Precision Medicine

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 375 - 375

Published: March 15, 2025

Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions

Language: Английский

Nanospanlastic in situ Gel for Nose to Brain Delivery of Nimodipine: In vitro Optimization and in vivo Pharmacokinetic Study

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Journal Year: 2025, Volume and Issue: 8(1), P. 97 - 105

Published: Feb. 18, 2025

Background: The FDA has approved the medication nimodipine (NMD) to treat vasospasm brought on by subarachnoid hemorrhage. most popular way administer NMD is intravenously, which can result in several adverse effects, including bradycardia, hypotension, arrhythmias, and inflammation at administration site. Objective: To evaluate effectiveness of nose-to-brain (NTB) delivery as spanlastic nanovesicles (SNV) situ gel into brain compare it with IV infusion. Methods: nanovesicle formulation ethanol injection method used Span 60 a non-ionic surfactant Tween an edge activator for enhanced permeability. within accepted range mixing poloxamer 407 cold method. Results: was observed optimized formula particle size 73.18 nm, PDI 0.1646, higher drug entrapment vesicles. shows gelation temperature nasal fluid temperature. vivo pharmacokinetic behavior NTB blood contrasted commercial NMD. In contrast intravenous NMD, results indicate that able deliver same amount tissue lower levels blood. Conclusions: approach NMD-SNV may be systemically less frequent dosing fewer cardiac effects.

Language: Английский

Application of nanomaterials in precision treatment of lung cancer

iScience, Journal Year: 2024, Volume and Issue: 28(1), P. 111704 - 111704

Published: Dec. 27, 2024

Lung cancer remains one of the most prevalent and lethal malignancies worldwide, characterized by high mortality rates due to its aggressive nature, metastatic potential, drug resistance. Despite advancements in conventional therapies, their efficacy is often limited systemic toxicity, poor tumor specificity, emergence resistance mechanisms. Nanomedicine has emerged as a promising approach address these challenges, leveraging unique physicochemical properties nanomaterials enhance delivery, reduce off-target effects, enable combination therapies. This review provides comprehensive overview applications lung treatment, focusing on chemotherapy, phototherapy, immunotherapy. Key strategies include development stimuli-responsive nanoparticles, active targeting mechanisms, multifunctional platforms for co-delivery therapeutic agents. Notable successes, such liposomal formulations polymeric highlight potential overcome biological barriers improve outcomes. However, significant challenges remain, including penetration, immunogenicity, scalability manufacturing, regulatory complexities. Addressing limitations through innovative design, advanced manufacturing technologies, interdisciplinary collaboration will be critical translating nanomedicine from bench bedside. Overall, represents transformative frontier therapy, offering patient outcomes quality life.

Language: Английский