Sustainable Synthesis of Substituted 1,3,5-Triazines by [ONO]-Pincer-Supported Nickel(II) Complexes via an Acceptorless Dehydrogenative Coupling Strategy DOI
Pennamuthiriyan Anandaraj, Rengan Ramesh, J.G. Małecki

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

A facile, cost-effective, and sustainable synthesis of substituted triazines from primary alcohols by newly synthesized nickel pincer-type complexes (1–3) has been described. Herein, we report the a set three well-defined Ni(II) O^N^O complexes, structurally characterized analytical, spectral, X-ray diffraction techniques. Further, are explored as efficient catalysts (4 mol %) for construction 2,4,6-substituted 1,3,5-triazines readily available via an acceptorless dehydrogenative coupling (ADC) strategy. wide range triazine derivatives (33 examples) benzamidine/guanidine hydrochloride with maximum isolated yield 92% under mild conditions, eco-friendly H2O H2 gas only byproducts. plausible mechanism proposed based on sequence control experiments. Interestingly, short antiulcer drug irsogladine large-scale 2,4-diphenyl-6-(p-tolyl)-1,3,5-triazine highlight convenience current methodology.

Language: Английский

Sustainable Synthesis of Substituted 1,3,5-Triazines by [ONO]-Pincer-Supported Nickel(II) Complexes via an Acceptorless Dehydrogenative Coupling Strategy DOI
Pennamuthiriyan Anandaraj, Rengan Ramesh, J.G. Małecki

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

A facile, cost-effective, and sustainable synthesis of substituted triazines from primary alcohols by newly synthesized nickel pincer-type complexes (1–3) has been described. Herein, we report the a set three well-defined Ni(II) O^N^O complexes, structurally characterized analytical, spectral, X-ray diffraction techniques. Further, are explored as efficient catalysts (4 mol %) for construction 2,4,6-substituted 1,3,5-triazines readily available via an acceptorless dehydrogenative coupling (ADC) strategy. wide range triazine derivatives (33 examples) benzamidine/guanidine hydrochloride with maximum isolated yield 92% under mild conditions, eco-friendly H2O H2 gas only byproducts. plausible mechanism proposed based on sequence control experiments. Interestingly, short antiulcer drug irsogladine large-scale 2,4-diphenyl-6-(p-tolyl)-1,3,5-triazine highlight convenience current methodology.

Language: Английский

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