Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 149 - 149

Published: Jan. 19, 2025

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder marked by the progressive degeneration of midbrain dopaminergic neurons and resultant locomotor dysfunction. Despite over two centuries recognition as chronic disease, exact pathogenesis PD remains elusive. The onset progression involve multiple complex pathological processes, with dysfunctional autophagy elevated oxidative stress serving critical contributors. Notably, emerging research has underscored interplay between in pathogenesis. Given limited efficacy therapies targeting either dysfunction or stress, it crucial to elucidate intricate mechanisms governing their develop more effective therapeutics. This review overviews role nuclear factor erythroid 2-related 2 (Nrf2), pivotal transcriptional regulator orchestrating cellular defense against these processes. By elucidating key processes PD, this will deepen our comprehensive understanding multifaceted underlying may uncover potential strategies for its prevention treatment.

Language: Английский

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An insight into nitrite-induced reproductive toxicity and the alleviation of injury by selenomethionine through activation of the Keap1/Nrf2 pathway in Procambarus clarkii

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141616 - 141616

Published: March 3, 2025

Language: Английский

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Research trends of ferroptosis and pyroptosis in Parkinson’s disease: a bibliometric analysis

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: May 16, 2024

Objective This study aims to visualize the trends and hotspots in research of “ferroptosis PD” “pyroptosis through bibliometric analysis from past 2024. Methods Literature was retrieved Web Science Core Collection (WoSCC) February 16, 2024, conducted using Vosviewer Citespace. Results 283 542 papers were collected field PD.” The number publications both fields has increased yearly, especially PD,” which will become focus PD research. China, United States England had extensive exchanges collaborations fields, more than 60% top 10 institutions China. In University Melbourne Nanjing Medical stood out terms publication numbers, citation frequency, centrality, most influential journals Cell Nature, respectively. keyword time zone map showed that molecular mechanisms neurons 2023, while memory receptor 2 may predict future direction. Conclusion provides insights into development, collaborations, themes, hotspots, tendencies Overall situation these is available for researchers further explore underlying potential treatments.

Language: Английский

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Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis

Journal of Geriatric Cardiology, Journal Year: 2024, Volume and Issue: 21(9), P. 899 - 912

Published: Sept. 1, 2024

Acute myocardial infarction (AMI) is a high-risk cardiovascular condition associated with increased cellular damage and oxidative stress. Aldo-Keto Reductase 1C3 (AKR1C3) stress-regulating gene. Nevertheless, its specific role mechanisms regarding AMI remain unclear.

Language: Английский

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