Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma DOI Creative Commons
Yuechun Zhu, Yu Feng,

Qinxuan Ni

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Abstract Myc-associated Zinc-finger Protein (MAZ) has been implicated in the malignant progression of various tumors. However, its expression and functional relationship MAZ melanoma have not previously investigated. This study confirms elevated melanoma, correlating with poor patient prognosis. Furthermore, our findings demonstrate that enhances by promoting proliferation, migration invasion. It is worth noting we found can target regulate NDUFS3 transcription to promote progression. Predictive modeling indicates co-expression could serve as a novel prognostic marker for patients.

Language: Английский

Beyond Adaptive Immunity: Trained Innate Immune Responses as a Novel Frontier in Hepatocellular Carcinoma Therapy DOI Open Access
Ching‐Hua Hsieh,

Pei-Chin Chuang,

Yueh‐Wei Liu

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1250 - 1250

Published: April 7, 2025

Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally, with the majority cases detected at advanced stages when curative options are limited. Current systemic therapies, including immune checkpoint inhibitors, demonstrate limited efficacy durable responses in only 15-20% patients. This poor response largely attributed to HCC's immunosuppressive microenvironment, which blunts effective T-cell responses. By illustrating that innate cells can acquire memory-like characteristics through process known as trained immunity, recent evidence has challenged conventional belief immunity devoid memory. review investigates potential defined by long-term functional reprogramming epigenetic, transcriptomic, and metabolic changes, provide new therapeutic opportunities for HCC. We discuss mechanisms transform HCC enhanced inflammatory cytokine production, repolarization tumor-associated macrophages toward anti-tumor phenotypes, increased cell infiltration, improved bridging adaptive immunity. further evaluate emerging strategies leveraging principles, BCG vaccination, β-glucan administration, cytokine-trained NK therapy, innovative combination approaches. Finally, we address resistance future directions clinical application. integrating into immunotherapeutic regimens, may significantly improve outcomes patients, potentially transforming disease more manageable condition.

Language: Английский

Citations

0
Myc-associated zinc finger protein: A “double-edged sword” in the malignant process of tumors DOI
Yu Feng,

Taiyu Xie,

Yu Huang

et al.

New discovery., Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: April 19, 2025

Myc-associated zinc finger protein (MAZ), a cysteine2-Histidine2 (C2H2)-type transcription factor, is widely expressed in human tissues and frequently dysregulated various malignancies, positioning it as promising target for cancer therapy. MAZ exerts dual regulatory effects on gene by binding to guanine-cytosine-rich (GC-rich) DNA sequences, modulating the of numerous genes. This review examines role progression hepatocellular carcinoma, breast cancer, renal pancreatic prostate other with focus recent advancements understanding its molecular mechanisms. These insights aim contribute development improved diagnostic therapeutic strategies cancer.

Language: Английский

Citations

0
ANKRD22 Induced by Transcription Factor MAZ Promotes Proliferation and Invasion of Nasopharyngeal Carcinoma DOI

Guoqing Gong,

Jie Yuan, Guang Yang

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(5)

Published: May 1, 2025

ABSTRACT Nasopharyngeal carcinoma (NPC) is very common in Southeast China, with the characteristics of high aggression and metastasis. Ankyrin repeat domain‐containing protein 22 (ANKRD22) contributes to tumor growth different tumors, but its role NPC still unknown. This study set out address action ANKRD22 progression NPC. The expression was examined by reverse transcription quantitative polymerase chain reaction western blot. function addressed through Cell Counting Kit‐8, flow cytometry, transwell, luciferase, chromatin immunoprecipitation, blot assays. Besides, vivo assessed using immunohistochemistry terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) assays after nude mice were administrated HK‐1 cells transfected sh‐ANKRD22. upregulated NPC, which predicted a poor prognosis patients. Knockdown suppressed invasion, enhanced apoptosis cells. Mechanically, MYC‐associated zinc finger (MAZ) factor that positively modulated MAZ/ANKRD22 axis accelerated proliferation repressed In vivo, silencing diminished size weight, Ki‐67 ANKRD22, increased transcriptionally MAZ, promoted

Language: Английский

Citations

0
Identification of vitamin D-related signature for predicting the clinical outcome and immunotherapy response in hepatocellular carcinoma DOI Creative Commons
Tianyi Wang,

Lulu Han,

Jinjiang Xu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(19), P. e37998 - e37998

Published: May 10, 2024

Hepatocellular carcinoma (HCC) is one of the most common cancers globally, seriously endangering people health. Vitamin D was significantly associated with tumor progression and patients’ prognosis. Integrative 10 machine learning algorithms were used to develop a D-related signature (VRS) training cohort 3 testing cohorts. The performance VRS in predicting immunology response verified using several approaches. optimal constructed by stepCox + superPC algorithm. acted as risk factor for HCC patients. patients high-risk score had poor clinical outcome AUCs 1-, 3-, 5-year ROC 0.786, 0.755, respectively. A higher level CD8 cytotoxic T cells B obtained low-risk score. There PD1&CTLA4 immunophenoscore TMB Lower TIDE escape found cases IC50 value camptothecin, docetaxel, crizotinib, dasatinib, erlotinib lower cancer-related hallmarks, including angiogenesis, glycolysis, NOTCH signaling. Our study proposed novel HCC, which served an indicator immunotherapy responses HCC.

Language: Английский

Citations

2
Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma DOI Creative Commons
Yu Feng,

Qinxuan Ni,

Na Wu

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 12, 2024

Myc-associated Zinc-finger Protein (MAZ) has been implicated in the malignant progression of various tumors. However, its expression and functional relationship MAZ melanoma have not previously investigated. This study confirms elevated melanoma, correlating with poor patient prognosis. Furthermore, our findings demonstrate that enhances by promoting proliferation, migration invasion. It is worth noting we found can target regulate transcription NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 (NDUFS3), a core subunit mitochondrial complex I, to enhance metabolism thus promote melanoma. Predictive modeling indicates co-expression NDUFS3 could serve as potential prognostic marker for patients.

Language: Английский

Citations

2
Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma DOI Creative Commons
Yuechun Zhu, Yu Feng,

Qinxuan Ni

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Abstract Myc-associated Zinc-finger Protein (MAZ) has been implicated in the malignant progression of various tumors. However, its expression and functional relationship MAZ melanoma have not previously investigated. This study confirms elevated melanoma, correlating with poor patient prognosis. Furthermore, our findings demonstrate that enhances by promoting proliferation, migration invasion. It is worth noting we found can target regulate NDUFS3 transcription to promote progression. Predictive modeling indicates co-expression could serve as a novel prognostic marker for patients.

Language: Английский

Citations

0