Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy DOI Creative Commons
Qirui Li,

Huiying Xu,

Rui-Ting Ma

et al.

Diabetes Therapy, Journal Year: 2024, Volume and Issue: 15(10), P. 2153 - 2182

Published: Aug. 21, 2024

Diabetes mellitus (DM) significantly impairs patients' quality of life, primarily because its complications, which are the leading cause mortality among individuals with disease. Autophagy has emerged as a key process closely associated DM, including complications such diabetic nephropathy (DN). DN is major complication contributing to chronic kidney disease and renal failure. The intricate connection between autophagy DN, highlights potential for new therapeutic targets. This review examines interplay these conditions, aiming uncover novel approaches treatment enhance our understanding their underlying pathophysiology. It also explores role in maintaining homeostasis involvement development progression DM DN. Furthermore, discusses natural compounds that may alleviate conditions by modulating autophagy.

Language: Английский

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved DOI Creative Commons
Simona Serini, Gabriella Calviello

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 486 - 486

Published: April 18, 2024

Chemotherapy-induced cognitive impairment or "chemobrain" is a prevalent long-term complication of chemotherapy and one the more devastating. Most studies performed so far to identify dysfunctions induced by antineoplastic chemotherapies have been focused on treatment with anthracyclines, frequently administered breast cancer patients, population that, after treatment, shows high possibility long survival and, consequently, chemobrain development. In last few years, different possible strategies explored prevent reduce anthracycline doxorubicin (DOX), known promote oxidative stress inflammation, which strongly implicated in development this brain dysfunction. Here, we critically analyzed results preclinical from years that evaluated potential phenolic compounds (PheCs), large class natural products able exert powerful antioxidant anti-inflammatory activities, inhibiting DOX-induced chemobrain. Several PheCs belonging classes shown be revert morphological damages deficits associated learning, memory, exploratory behavior. We biological molecular mechanisms suggested future perspectives research area.

Language: Английский

Citations

4
Effect of Resveratrol and Quercetin on SFRP4 as a Biomarker of Diabesity: In Silico and In Vivo Studies DOI
Asim Rehman, Shazia Anwer Bukhari, Zunera Chauhdary

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151748 - 151748

Published: April 1, 2025

Language: Английский

Citations

0
Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy DOI Creative Commons
Qirui Li,

Huiying Xu,

Rui-Ting Ma

et al.

Diabetes Therapy, Journal Year: 2024, Volume and Issue: 15(10), P. 2153 - 2182

Published: Aug. 21, 2024

Diabetes mellitus (DM) significantly impairs patients' quality of life, primarily because its complications, which are the leading cause mortality among individuals with disease. Autophagy has emerged as a key process closely associated DM, including complications such diabetic nephropathy (DN). DN is major complication contributing to chronic kidney disease and renal failure. The intricate connection between autophagy DN, highlights potential for new therapeutic targets. This review examines interplay these conditions, aiming uncover novel approaches treatment enhance our understanding their underlying pathophysiology. It also explores role in maintaining homeostasis involvement development progression DM DN. Furthermore, discusses natural compounds that may alleviate conditions by modulating autophagy.

Language: Английский

Citations

2