Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(6), P. 105796 - 105796
Published: April 20, 2024
The
chemistry
of
hydrazones
is
currently
undergoing
intensive
development.
For
example,
thioacylhydrazones,
which
are
synthesized
most
often
from
thiosemicarbazides,
have
become
very
popular
in
recent
years
owing
to
impressive
results
their
extensive
testing
medicinal
chemistry.
Their
antiviral,
insecticidal,
antisclerotic,
antioxidant,
and
antiparasitic
activities
been
demonstrated;
thioacylhydrazones
showed
promise
for
the
development
drugs
against
COVID-19
HIV.
ligands
based
on
these
compounds
with
soft
donor
nitrogen
sulfur
atoms
widely
used
creation
complexes
various
bioactivities,
including
strong
anticancer
properties.
Since
replacement
oxygen
atom
a
may
increase
biological
activity
compound,
desire
expand
spectrum
pharmacological
action
or
change
type
induces
understandable
interest
thio
analogues
acylhydrazones
that
known
high
bioactivity.
At
same
time,
there
publications
indicating
oxamic
acid
thiohydrazides
containing
thioamide
thiohydrazide
moieties,
due
polyfunctional
nature,
can
be
effectively
synthesis
wide
variety
compounds,
bioactive
products.
This
review
describes
synthetic
applied
potential
poorly
investigated
them.
A
considerable
benefit
derivatives
presence
an
additional
carboxamide
group,
itself
significant
processes
also
easily
modified,
thus
providing
wealth
combinations
new
promising
convenient
methods
preparation
this
demonstrates
large
potential,
opens
up
way
thiohydrazone
heterocyclic
new-generation
antibacterial
targeting
secretory
system
bacteria,
suppressing
infectious
process
eliminating
pathogen
body
without
affecting
proliferation
bacteria.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 27, 2022
The
great
success
of
cisplatin
as
a
chemotherapeutic
agent
considerably
increased
research
efforts
in
inorganic
biochemistry
to
identify
more
metallic
drugs
having
the
potential
treating
lung
cancer.
Metal
coordination
centres,
which
exhibit
wide
range
numbers
and
geometries,
various
oxidised
reduced
states
inherent
ligand
properties
offer
pharmaceutical
chemists
plethora
drug
structures.
Owing
presence
C=N
C=S
bonds
thiosemicarbazone
Schiff
base,
N
S
atoms
its
hybrid
orbital
has
lone
pair
electrons,
can
generate
metal
complexes
with
different
stabilities
most
elements
under
certain
conditions.
Such
ligands
play
key
roles
treatment
anti-lung
Research
regarding
cancer
advanced
considerably,
but
there
remain
several
challenges.
In
this
review,
we
discuss
base
drugs,
their
anti-cancer
activities
likely
action
mechanisms
involving
recent
families
copper,
nickel,
platinum,
ruthenium
other
complexes.
Journal of Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
66(8), P. 5669 - 5684
Published: April 18, 2023
To
develop
the
next-generation
Pt
drug
with
remarkable
activity
and
low
toxicity
to
maximally
inhibit
tumor
growth,
we
optimized
a
Pt(II)
thiosemicarbazone
compound
(C4)
cytotoxicity
SK-N-MC
cells
then
constructed
new
human
serum
albumin-C4
(HSA-C4)
complex
delivery
system.
The
in
vivo
results
showed
that
C4
HSA-C4
have
therapeutic
efficiency
almost
no
toxicity;
they
induced
apoptosis
inhibited
angiogenesis.
This
system
potential
as
practical
drug.
study
could
pave
way
for
developing
dual-targeted
drugs
achieving
their
targeting
therapy
cancer.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(18), P. 4455 - 4455
Published: Sept. 14, 2022
COTI-2
is
currently
being
evaluated
in
a
phase
I
clinical
trial
for
the
treatment
of
gynecological
and
other
solid
cancers.
As
thiosemicarbazone,
this
compound
contains
an
N,N,S-chelating
moiety
is,
therefore,
expected
to
bind
endogenous
metal
ions.
However,
besides
zinc,
interaction
properties
have
not
been
investigated
detail
so
far.
This
unexpected,
as
we
recently
shown
that
forms
stable
ternary
complexes
with
copper
glutathione,
which
renders
drug
substrate
resistance
efflux
transporter
ABCC1.
Herein,
complex
formation
COTI-2,
two
novel
terminal
N-disubstituted
derivatives
(COTI-NMe
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(15), P. 12010 - 12010
Published: July 27, 2023
Topoisomerases,
common
targets
for
anti-cancer
therapeutics,
are
crucial
enzymes
DNA
replication,
transcription,
and
many
other
aspects
of
metabolism.
The
potential
effects
thiosemicarbazones
(TSC)
metal-TSC
complexes
have
been
demonstrated
to
target
several
biological
processes,
including
Human
topoisomerases
were
discovered
among
the
molecular
TSCs,
metal-chelated
TSCs
specifically
displayed
significant
inhibition
topoisomerase
II.
processes
by
which
metal-TSCs
or
inhibit
still
being
studied.
In
this
brief
review,
we
summarize
that
various
types
human
topoisomerases,
note
some
key
unanswered
questions
regarding
interesting
class
diverse
compounds.
ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(19), P. 16547 - 16560
Published: May 3, 2022
This
paper
deals
with
the
synthesis,
structural
studies,
and
behavior
in
solution
of
unprecedented
coordination
complexes
built
by
association
a
panel
14
representative
thiosemicarbazone
ligands
cluster
[Mo2O2S2]2+.
These
have
been
thoroughly
characterized
both
solid
state
XRD
NMR,
respectively.
In
particular,
HMBC
1H{15N}
1H
DOSY
NMR
experiments
bring
important
elements
for
understanding
complexes'
solution.
studies
demonstrate
that
playing
on
nature
position
various
substituents
strongly
influences
modes
as
well
numbers
isomers
solution,
mainly
2
products
majority
up
to
5
some
them.
