Activation of sirtuin 3 and maintenance of mitochondrial homeostasis by artemisinin protect against diclofenac-induced kidney injury in rats DOI Creative Commons
Doaa Hellal, Sarah Ragab Abd El‐Khalik,

Heba M. Arakeep

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Nonsteroidal anti-inflammatory drug (NSAID)-induced kidney injury is one of the most common causes renal failure. The exact pathogenesis NSAID induced not fully known and treatment still challenging. Artemisinin (ART) gains more attention by its potent biological activities in addition to antimalarial effect. In our research, we evaluated preventive therapeutic effects ART Diclofenac (DIC) through effect on mitochondria regulation sirtuin 3 (SIRT3). Thirty adult male Sprague Dawley rats were divided into five groups: control, ART, DIC, DIC + prophylactic, followed groups. At end study, animals scarified following parameters evaluated: serum urea creatinine, malondialdehyde (MDA), superoxide dismutase (SOD) nitrate. SIRT3 was detected western blotting real-time PCR. Mitochondrial related markers (PGC-1α, Drp1, mitochondrial ATP) immunoassay. Caspase-3 LC3 II expression tissues demonstrated immune-histochemical staining. specimens stained for H&E PAS special stain. Electron microscopy done detect morphology. improved function test, oxidative stress, level, function, decrease caspase-3. Histopathological examination confirmed alleviation as determined light or electron microscopy. can modulate biochemical pathological changes DIC-induced be considered a new possible approach SIR3 maintenance homeostasis.

Language: Английский

Falcipain-2: A review on structurally diverse non-peptide inhibitors DOI
Vandana Pandey,

John F. Kennedy,

Neera Raghav

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142817 - 142817

Published: April 1, 2025

Language: Английский

Citations

0
Molecular dynamics insight of interaction between Artemisinin and its derivatives and the cancer cell membrane DOI Creative Commons

Samaneh Boroomand,

Delara Mohammad-Aghaie,

Fatemeh Mohammadpour

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract In the present study, molecular dynamics simulation approach has been utilized to investigate effectiveness of four molecules, including Artemisinin, a natural product, and its derivatives Dihydroartemisinin, Artesunate, Artemisone, on cancer cell membrane model. Performed simulations predicted that Dihydroartemisinin Artemisone form stronger hydrogen bonds with membrane, exhibit higher mobility, have longer lifetime at water-membrane interface. molecules could penetrate hydrophobic part lipid’s tail which led fluidity membrane. These two compounds were able exert greatest effect change properties characteristics model while showing anti-cancer effects than other compounds. The outcomes predictions found agree results experimental studies. There is noticeable difference in way enter compared Artemisinin Artesunate. former from functional group side into latter pass it peroxide ring side.

Language: Английский

Citations

0
Molecular dynamics insight of interaction between Artemisinin and its derivatives and the cancer cell membrane DOI

Samaneh Boroomand,

Delara Mohammad-Aghaie,

Fatemeh Mohammadpour

et al.

Computational and Theoretical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 114997 - 114997

Published: Nov. 1, 2024

Language: Английский

Citations

0
Activation of sirtuin 3 and maintenance of mitochondrial homeostasis by artemisinin protect against diclofenac-induced kidney injury in rats DOI Creative Commons
Doaa Hellal, Sarah Ragab Abd El‐Khalik,

Heba M. Arakeep

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Nonsteroidal anti-inflammatory drug (NSAID)-induced kidney injury is one of the most common causes renal failure. The exact pathogenesis NSAID induced not fully known and treatment still challenging. Artemisinin (ART) gains more attention by its potent biological activities in addition to antimalarial effect. In our research, we evaluated preventive therapeutic effects ART Diclofenac (DIC) through effect on mitochondria regulation sirtuin 3 (SIRT3). Thirty adult male Sprague Dawley rats were divided into five groups: control, ART, DIC, DIC + prophylactic, followed groups. At end study, animals scarified following parameters evaluated: serum urea creatinine, malondialdehyde (MDA), superoxide dismutase (SOD) nitrate. SIRT3 was detected western blotting real-time PCR. Mitochondrial related markers (PGC-1α, Drp1, mitochondrial ATP) immunoassay. Caspase-3 LC3 II expression tissues demonstrated immune-histochemical staining. specimens stained for H&E PAS special stain. Electron microscopy done detect morphology. improved function test, oxidative stress, level, function, decrease caspase-3. Histopathological examination confirmed alleviation as determined light or electron microscopy. can modulate biochemical pathological changes DIC-induced be considered a new possible approach SIR3 maintenance homeostasis.

Language: Английский

Citations

0