Sarcopenia’s Impact Defined by Grip Strength and Muscle Mass on Post-hepatectomy Outcomes: A Multicenter Analysis DOI Open Access
Sotaro Fukuhara,

TSUYOSHI KOBAYASHI,

Michinori Hamaoka

et al.

In Vivo, Journal Year: 2024, Volume and Issue: 38(6), P. 2827 - 2835

Published: Oct. 29, 2024

Background/Aim: Sarcopenia is diagnosed based on grip strength and skeletal muscle mass. Although decreased mass has been reported to be associated with poor outcomes after hepatectomy, a few studies have included data in hepatectomy candidates. This multicenter study investigated the clinical factors postoperative complications sarcopenia by assessing patients undergoing for hepatocellular carcinoma (HCC). Patients Methods: Data from who underwent HCC between January 2020 March 2022 were retrospectively collected multi-institutional databases. was defined as reduced The categorized into non-sarcopenia groups, baseline characteristics short term compared two groups. Results: Overall, 253 included, among which 36 (14.2%) had sarcopenia. group significantly older age, low body index, comorbid heart or chronic pulmonary disease, cerebrovascular accident history, overall major group. Among [Clavien-Dindo classification (CDC) ≥III], incidence of bile leakage intra-abdominal abscess higher than Multivariate analysis revealed that an independent risk factor (CDC ≥III). Conclusion: Sarcopenia, mass, predictor HCC.

Language: Английский

Predictive value of osteopenia as prognostic marker for survival and recurrence in patients with gastrointestinal cancers: a systematic review and meta-analysis DOI Creative Commons
Xinmei Zou, Yang Wang

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 1, 2025

Background Early detection, systematic prevention, and personalized therapy are crucial to reduce mortality in patients with gastrointestinal (GI) cancers. This review meta-analysis aimed clarify the predictive value of osteopenia osteosarcopenia as prognostic markers survival recurrence GI Methods Medline, Google Scholar, Science Direct databases were searched for English-language studies that included who underwent surgical resection following a pathologically diagnosed cancer reported association between on overall (OS) recurrence-free (RFS). Meta-analysis was done using STATA 14.2, results pooled hazard ratios (HR) 95% confidence intervals (CI). Heterogeneity assessed I2 statistic Chi-square test. Study quality evaluated Newcastle Ottawa Scale (NOS). Results A comprehensive literature search yielded 23 eligible studies, primarily from Japan. Osteopenia emerged significant risk factor both OS (pooled HR 2.20, CI: 1.74–2.79) RFS 2.15, 1.60–2.89). Patients exhibited threefold higher rates 2.96, 1.99–4.40) heightened 2.75, 1.79–4.24). Subgroup analyses underscored consistency these associations across diverse contexts. Conclusion establishes robust indicators Integrating musculoskeletal assessments into routine oncological care is imperative timely interventions optimized patient outcomes.

Language: Английский

Citations

0
Advancements in sarcopenia diagnosis: from imaging techniques to non-radiation assessments DOI Creative Commons
Salvatore Lavalle, Rosa Scapaticci,

Edoardo Masiello

et al.

Frontiers in Medical Technology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 9, 2024

Sarcopenia is a prevalent condition with significant clinical implications, and it expected to escalate globally, demanding for effective diagnostic strategies, possibly at an early stage of the disease. Imaging techniques play pivotal role in comprehensively evaluating sarcopenia, offering insights into both muscle quantity quality. Among all imaging currently used diagnosis follow up possible distinguish two classes: Rx based techniques, using ionizing radiations, non-invasive which are on use safe low risk procedures. Dual-energy x-ray Absorptiometry Computed Tomography, while widely utilized, entail radiation exposure concerns. Ultrasound offers portability, real-time imaging, absence radiation, making promising tool Magnetic Resonance Imaging, particularly T1-weighted Dixon sequences, provides cross- sectional high-resolution images fat-water separation capabilities, facilitating precise sarcopenia quantification. Bioelectrical Impedance Analysis (BIA), technique, estimates body composition, including mass, albeit influenced by hydration status. Standardized protocols, such as those proposed through (SARCUS) Working Group, imperative ensuring consistency across assessments. Future research should focus refining these harnessing potential radiomics artificial intelligence enhance accuracy prognostic capabilities sarcopenia.

Language: Английский

Citations

1
Association between possible sarcopenia, all-cause mortality, and adverse health outcomes in community-dwelling older adults in China DOI Creative Commons
Bingyang Liu,

Ruiyan Liu,

Yuhong Jin

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 29, 2024

The relationship between possible sarcopenia and mortality remains ambiguous within Asian populations. To clarify this, we investigated the association in older adults residing Chinese communities. Utilizing data from China Health Retirement Longitudinal Study, this population-based cohort study included individuals aged ≥ 60 years, followed 2011 to 2012 through 2020. Possible was defined accordance with Working Group on Sarcopenia 2019 criteria, Cox proportional hazards regression used analyze its impact mortality, while exploratory analyses were conducted investigate associations of chronic diseases, functional independence, hospitalization frequency. encompassed 5,160 participants (median age: 66 years), nearly half whom (48.8%) identified sarcopenia. Over a 9-year follow-up period, there 1216 recorded deaths. Analysis indicated that faced significantly elevated risk compared their counterparts (HR: 1.79, 95% CI: 1.58-2.03; P < 0.001). Further, subgroup confirmed strong all-cause across various subgroups, including those related sex, obesity status, living environment. Additionally, revealed associated an increased likelihood heart disease (OR = 1.18, 1.03-1.34, 0.014) stroke 1.41, 1.19-1.68, 0.001), as well reduced independence (β -0.17, -0.24--0.10, also higher frequency hospitalizations at baseline (Exp(β) 1.50, 1.25-1.81, although no longer significant during period. In conclusion, community-dwelling adults, several dependence. Thus, alleviating or preventing may improve health outcomes extend lifespan these individuals.

Language: Английский

Citations

1
Sarcopenia’s Impact Defined by Grip Strength and Muscle Mass on Post-hepatectomy Outcomes: A Multicenter Analysis DOI Open Access
Sotaro Fukuhara,

TSUYOSHI KOBAYASHI,

Michinori Hamaoka

et al.

In Vivo, Journal Year: 2024, Volume and Issue: 38(6), P. 2827 - 2835

Published: Oct. 29, 2024

Background/Aim: Sarcopenia is diagnosed based on grip strength and skeletal muscle mass. Although decreased mass has been reported to be associated with poor outcomes after hepatectomy, a few studies have included data in hepatectomy candidates. This multicenter study investigated the clinical factors postoperative complications sarcopenia by assessing patients undergoing for hepatocellular carcinoma (HCC). Patients Methods: Data from who underwent HCC between January 2020 March 2022 were retrospectively collected multi-institutional databases. was defined as reduced The categorized into non-sarcopenia groups, baseline characteristics short term compared two groups. Results: Overall, 253 included, among which 36 (14.2%) had sarcopenia. group significantly older age, low body index, comorbid heart or chronic pulmonary disease, cerebrovascular accident history, overall major group. Among [Clavien-Dindo classification (CDC) ≥III], incidence of bile leakage intra-abdominal abscess higher than Multivariate analysis revealed that an independent risk factor (CDC ≥III). Conclusion: Sarcopenia, mass, predictor HCC.

Language: Английский

Citations

0